New Orleans Saints at Indianapolis Colts odds, picks and predictions

Analyzing Sunday’s New Orleans Saints at Indianapolis Colts odds and lines, with expert NFL picks and predictions.

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The New Orleans Saints (3-4) face the Indianapolis Colts (3-4) Sunday in Week 8 NFL action. Kickoff at Lucas Oil Stadium is scheduled for 1 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Saints vs. Colts odds, and make our expert NFL picks and predictions.

The Saints fell for the 4th time in their last 5 games with a 31-24 home loss against the Jacksonville Jaguars on Thursday Night Football in Week 7. They failed to cover as 2.5-point favorites but easily went over the total of 41.5. QB Derek Carr completed 33 passes, 12 of which went to his RB Alvin Kamara for 91 yards.

The Colts lost a heartbreaker at home in Week 7 to Cleveland, 39-38, after Browns RB Kareem Hunt plunged across the goal line with 15 seconds remaining. QB Gardner Minshew threw for over 300 yards and 2 touchdowns, 1 of which went to WR Josh Downs who led all receivers with 125 yards.

The Saints have won the last 4 head-to-head meetings between these teams. The last time they met was Dec. 16, 2019, and the Saints easily covered as 8-point home favorites in a 34-7 victory.

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Saints at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:55 p.m. ET.

  • Moneyline (ML): Saints -130 (bet $130 to win $100) | Colts +110 (bet $110 to win $100)
  • Against the spread (ATS): Saints -1.5 (-115) | Colts +1.5 (-105)
  • Over/Under (O/U): 43.5 (O: -110 | U: -110)

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Saints at Colts key injuries

Saints

  • LB Demario Davis (knee) questionable
  • QB Taysom Hill (chest) questionable
  • TE Juwan Johnson (calf) questionable
  • S Tyrann Mathieu (foot) questionable
  • OG Andrus Peat (ankle) questionable

Colts

  • DT Eric Johnson II (ankle) questionable
  • RB Zack Moss (elbow/heel) questionable
  • TE Kylen Granson (concussion) out
  • CB JuJu Brents (quad) out

Saints at Colts picks and predictions

Prediction

Saints 20, Colts 17

Moneyline

PASS.

This game is basically a coin flip in my mind. The Colts offense has been producing 25.4 points per game, but their defense has allowed the 3rd-most PPG (27.5) in the NFL. The Saints defense has kept them in games by holding opponents to just 18.1 PPG, but the offense has struggled with consistency. I’d rather stay away and look to the total in this one.

Against the spread

AVOID.

I am going to target the total with my bet.

Over/Under

BET UNDER 43.5 (-110).

These 2 teams have gone under the total in 4 of their last 5 head-to-head matchups. New Orleans has been Under in 9 of their last 10 games because of their defensive prowess. I know that Minshew will be under a lot of pressure — the Colts allow nearly 3 sacks per game.

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