Nick Bosa
The Commanders offensive tackles are beat up, including the fact that Charles Leno is already declared to be out and Andrew Wylie has missed time this week, attempting to heal.
Bosa could really make things absolutely miserable for the Commanders quarterback, Sunday, whether that be Jacoby Brissett or Sam Howell. Bosa has already registered 10.5 quarterback sacks, 14 tackles for a loss and an impressive 33 quarterback hits.
Christian McCaffrey
McCaffrey is a workhorse like no other in the NFL. The 49ers look to get him the ball early and often in every game. Consequently, he leads the NFL in rushing attempts (258), rushing yards (1,395) touches from scrimmage (321) and total yards from scrimmage (1,932). He has 14 rushing touchdowns and 7 receiving touchdowns.
George Kittle
With the game tied 7-7 last year at the half, Kittle got loose on two consecutive possessions for a 34-yard touchdown and a 33-yard touchdown. With the Commanders safeties Darrick Forrest and Percy Butler being out Sunday, Kittle could be unstoppable.
Brock Purdy
Frankly, the Commanders pass rush has been virtually non-existant since the trades of Montez Sweat and Chase Young. Purdy thrives in situations where he can use play action and find open receivers because the secondary has to honor the 49ers run fakes. Purdy’s effectiveness is beyond question, especially when the 49ers take the lead. He leads the NFL in yards per passing attempt (9.7), yards per completion (14.2), passer rating (112.2) and QBR (71.7). He has passed for 29 touchdowns and 11 interceptions.