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The Los Angeles Rams (1-2) will be on the road for the 2nd straight week as they face the Indianapolis Colts (2-1) Sunday afternoon. Kickoff from Lucas Oil Stadium will be at 1 p.m. ET (FOX) between these two cross-conference foes. Below, we analyze BetMGM Sportsbook’s lines around the Rams vs. Colts odds, and make our expert NFL picks and predictions.
The Rams have dropped 2 games in a row after beating the Seattle Seahawks in Week 1, losing to the San Francisco 49ers and Cincinnati Bengals. It’s a short week for the Rams, too, after facing the Bengals on the road Monday night. Despite losing 2 straight, the Rams are still 2-0-1 against the spread this season thanks to a backdoor cover and push the last 2 weeks.
The Colts stumbled in Week 1, but they’ve bounced back with 2 straight wins over the Houston Texans and Baltimore Ravens. QB Anthony Richardson missed the last game-and-a-half, but QB Gardner Minshew did a great job in his place, leading the Colts to back-to-back wins. Richardson is due back this week.
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Rams at Colts odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9:45 a.m. ET.
- Moneyline (ML): Rams -110 (bet $110 to win $100) | Colts -110 (bet $110 to win $100)
- Against the spread (ATS): Rams +1 (-115) | Colts -1 (-105)
- Over/Under (O/U): 46 (O: -110 | U: -110)
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Rams at Colts key injuries
Rams
- TE Tyler Higbee (Achilles) questionable
- LT Alaric Jackson (hamstring) questionable
- WR Puka Nacua (oblique) questionable
- RG Joe Noteboom (knee) questionable
Colts
- DT DeForest Buckner (groin) questionable
- C Ryan Kelly (concussion) questionable
- G Quenton Nelson (toe) questionable
- QB Anthony Richardson (concussion) questionable
Rams at Colts picks and predictions
Prediction
Rams 23, Colts 20
Moneyline
This game is essentially a pick ’em with both teams at -110 on the money line, and while the Rams are technically a slim underdog with the spread, I like them to win this game. The offensive line was a mess Monday night after Jackson got injured, and his replacement, LT Zach Thomas, was a turnstile for Bengals defenders.
I think Sean McVay will learn from his mistakes against Cincinnati and have more balance on offense, leaning more on the run rather than putting the ball in QB Matthew Stafford’s hands on nearly every play. BET RAMS (-110) to win outright on the road.
Against the spread
Getting 1 point in the NFL doesn’t mean a whole lot, and it’s probably not worth the extra juice to take the Rams +1 at (-115). If you’re confident in Los Angeles winning, simply take the Rams to win straight-up.
Over/Under
Coming off a Monday night road game, the Rams had to travel for this game again, flying from the West Coast to Indianapolis for an early 10 a.m. PT kickoff. It’s possible they’ll come out a little bit sluggish, and for the Colts, they could also start slow with Richardson kicking off some rust.
With both defenses playing relatively well and questions on the offensive side for each team, I like the UNDER 46 (-110).
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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