Coming off a dominant Week 1 win, the Los Angeles Rams (1-0) will be on the road in Week 2 against the Indianapolis Colts (0-1). The cross-conference opponents will play in a 1 p.m. ET Sunday kickoff at Lucas Oil Stadium. Below, we look at the Rams vs. Colts odds and lines; check back for our NFL picks and predictions.
The Rams crushed the Chicago Bears in the season opener Sunday night, winning 34-14 at home. QB Matthew Stafford had a historically great debut with Los Angeles, throwing for 321 yards and 3 touchdowns with a career-best 156.1 passer rating.
The defense held Chicago to only 14 points and had two takeaways, while also stopping the Bears twice on fourth down. It was an all-around great team effort by Los Angeles in Week 1.
The Colts were knocked off by the Seahawks at Lucas Oil Stadium, falling 28-16. Seattle’s defense stepped up and held the Colts to 336 total yards. QB Carson Wentz threw for 251 yards and 2 TD in his Colts debut.
Rams at Colts odds, spread and line
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 4:45 p.m. ET.
- Money line: Rams -205 (bet $205 to win $100) | Colts +165 (bet $100 to win $165)
- Against the spread (ATS): Rams -4.5, -107 (bet $107 to win $100) | Colts +4.5, -115 (bet $115 to win $100)
- Total (O/U): 47.5, Over -108 (bet $108 to win $100) | Under -112 (bet $112 to win $100)
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2021 betting stats:
- ML: Rams 1-0 | Colts 0-1
- ATS: Rams 1-0 | Colts 0-1
- O/U: Rams 1-0 | Colts 0-1
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Rams at Colts head-to-head
Being in different conferences, the Rams and Colts don’t square off very often. They play just once every four years, with their most recent meeting coming in 2017. That was Sean McVay’s first game as head coach of the Rams, a blowout 46-9 victory by Los Angeles at home.
The Rams also beat the Colts 38-8 in 2013 when they were still residing in St. Louis and were led by QB Kellen Clemens and his 247 yards with 2 touchdowns. The matchup before that came in 2009, a 42-6 win by the Colts on the road.
So in the last three meetings, the average margin of victory has been 34.3 points. The favorite is 2-1 in the last three meetings between these two teams and the total went to the Over three times.
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