Los Angeles Rams vs. Indianapolis Colts odds lines money line against the spread Over Under

First look: Los Angeles Rams at Indianapolis Colts odds and lines

Looking at Sunday’s Los Angeles Rams at Indianapolis Colts Week 4 NFL odds, lines and trends. Here’s what you need to know.

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The Los Angeles Rams (1-2) and Indianapolis Colts (2-1) will square off in Week 4 on Sunday afternoon at Lucas Oil Stadium in Indianapolis. Kickoff is set for 1 p.m. ET (FOX). Below, we look at Rams vs. Colts odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The Rams lost at the Cincinnati Bengals 19-16 on Monday night to wrap up Week 3. They’ve now lost 2 straight after beating the Seattle Seahawks in the opener, dropping into a tie with the Arizona Cardinals for last in the NFC West.

The Colts stunned the Baltimore Ravens 22-19 in overtime on Sunday afternoon. Indianapolis is now 2-1 on the year, exceeding early expectations thus far despite being without QB Anthony Richardson for the last game and a half after he suffered a concussion. QB Gardner Minshew II stepped in and went 27 of 44 for 227 yards and a TD.

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Rams at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 10:56 a.m. ET.

Moneyline (ML): Rams -105 (bet $105 to win $100) | Colts -115 (bet $115 to win $100)
Against the spread (ATS): Rams +1 (-110) | Colts -1 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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2023 betting stats

ML: Rams 1-2 | Colts 2-1
ATS: Rams 2-0-1 | Colts 2-1
O/U: Rams 1-2 | Colts 2-1

Rams vs. Colts head-to-head

Being in separate conferences, the Rams and Colts have only met 4 times since 2009. The Rams are 3-1 straight-up in that span, winning each of the last 3 meetings. The teams have split the series 2-2 straight up and against the spread, and the total has gone Over in each of the last 4 games.

One team has scored at least 38 points in 3 of their last 4 meetings, while their last matchup was a 27-24 win by the Rams in 2021.

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First look: Los Angeles Rams at Indianapolis Colts odds and lines

Looking at Sunday’s Los Angeles Rams at Indianapolis Colts Week 2 NFL odds, lines and trends. Here’s what you need to know.

Coming off a dominant Week 1 win, the Los Angeles Rams (1-0) will be on the road in Week 2 against the Indianapolis Colts (0-1). The cross-conference opponents will play in a 1 p.m. ET Sunday kickoff at Lucas Oil Stadium. Below, we look at the Rams vs. Colts odds and lines; check back for our NFL picks and predictions.

The Rams crushed the Chicago Bears in the season opener Sunday night, winning 34-14 at home. QB Matthew Stafford had a historically great debut with Los Angeles, throwing for 321 yards and 3 touchdowns with a career-best 156.1 passer rating.

The defense held Chicago to only 14 points and had two takeaways, while also stopping the Bears twice on fourth down. It was an all-around great team effort by Los Angeles in Week 1.

The Colts were knocked off by the Seahawks at Lucas Oil Stadium, falling 28-16. Seattle’s defense stepped up and held the Colts to 336 total yards. QB Carson Wentz threw for 251 yards and 2 TD in his Colts debut.

Rams at Colts odds, spread and line

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 4:45 p.m. ET.

Money line: Rams -205 (bet $205 to win $100) | Colts +165 (bet $100 to win $165)
Against the spread (ATS): Rams -4.5, -107 (bet $107 to win $100) | Colts +4.5, -115 (bet $115 to win $100)
Total (O/U): 47.5, Over -108 (bet $108 to win $100) | Under -112 (bet $112 to win $100)

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2021 betting stats:

ML: Rams 1-0 | Colts 0-1
ATS: Rams 1-0 | Colts 0-1
O/U: Rams 1-0 | Colts 0-1

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Rams at Colts head-to-head

Being in different conferences, the Rams and Colts don’t square off very often. They play just once every four years, with their most recent meeting coming in 2017. That was Sean McVay’s first game as head coach of the Rams, a blowout 46-9 victory by Los Angeles at home.

The Rams also beat the Colts 38-8 in 2013 when they were still residing in St. Louis and were led by QB Kellen Clemens and his 247 yards with 2 touchdowns. The matchup before that came in 2009, a 42-6 win by the Colts on the road.

So in the last three meetings, the average margin of victory has been 34.3 points. The favorite is 2-1 in the last three meetings between these two teams and the total went to the Over three times.

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