Pittsburgh at Duke odds, picks and predictions

Analyzing Wednesday’s Pittsburgh at Duke odds and lines, with college basketball expert picks, predictions and best bets.

The Pittsburgh Panthers (11-5, 4-1 ACC) meet the No. 21 Duke Blue Devils (12-4, 3-2) Wednesday at Cameron Indoor Stadium in Durham, N.C. Tip-off is scheduled for 7 p.m. ET (ACC Network). Below, we analyze Tipico Sportsbook’s lines around the Pittsburgh vs. Duke odds, and make our expert college basketball picks, predictions and bets.

Rankings courtesy of the USA TODAY Sports Coaches Poll.

The Panthers took their first ACC loss at home against Clemson in a 75-74 setback over the weekend. That loss snapped a 5-game win streak, and the non-cover halted an impressive 10-0 run against the spread (ATS). The Over is 4-0 in the past 4 games overall for Pitt while cashing at an 8-2 clip in the past 10 games overall.

The Blue Devils rebounded from an embarrassing 84-60 loss at NC State last Wednesday by picking up a narrow win 65-64 at Boston College last time out on Saturday. Duke has alternated wins and losses in the past 5 outings while going 1-4 ATS during the span.

Stream select live college basketball games and full replays: Get ESPN+

Pittsburgh at Duke odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:20 a.m. ET.

  • Moneyline (ML): Off the board (OTB)
  • Against the spread (ATS): Pittsburgh +8.5 (-115) | Duke -8.5 (-105)
  • Over/Under (O/U): 141.5 (O: -115 | U: -105)

Catch the excitement and bet with Tipico

Double Down, Ohio! Deposit $200, Get $250. Bet now!

In Colorado and New Jersey, claim your 100% Deposit Match up to $250 now. Bet now! 21+, see Tipico.com for Terms and Conditions.

Pittsburgh at Duke picks and predictions

Prediction

Duke 74, Pittsburgh 69

Moneyline

The money line is OTB at the time of publishing.

However, Duke would be too heavy of a favorite and wouldn’t be worth pursuing anyway.

PASS.

Against the spread

PITTSBURGH +8.5 (-115) is worth a look catching more than 4 buckets.

The Panthers lost their first conference game against Clemson over the weekend, going a perfect 4-0 SU and ATS in their previous 4 ACC tilts.

Duke has cashed in just 1 of the previous 5 games overall. In addition, the Blue Devils are just 2-3 ATS in the past 5 home games while splitting its 2 conference tilts on their home floor.

Over/Under

OVER 141.5 (-115) is worth playing but go very, very lightly. It will likely take a late free throw or two to inch this one across the finish line.

The Over is 4-0 in the past 4 games overall for Pitt while going 5-1-1 in its last 7 road outings.

The Over is 4-1 in the past 5 home games for Duke and 12-5 in its last 17 games following a non-cover.

Play our free daily Pick’em Challenge and win! Play now!

Want action on this basketball game or any other sports contest? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in OH, CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1667]