First look: Green Bay Packers at Buffalo Bills odds and lines

Looking at Sunday’s Green Bay Packers at Buffalo Bills Week 8 NFL odds, lines and trends. Here’s what you need to know.

The Green Bay Packers (3-4) and Buffalo Bills (5-1) will tussle on Sunday Night Football in Week 8. The Highmark Stadium battle will get underway at 8:20 p.m. ET (NBC). Below, we look at Packers vs. Bills odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

Green Bay lost 23-21 at the Washington Commanders Sunday, dropping its 3rd straight game. The Packer offense amassed a season-low of 232 total yards. Green Bay — favored by 4 — went 0-for-6 on 3rd downs and possessed the football for just 22:53. The Packers are now 0-4 against the spread in October.

The Bills head into this home game off a bye week following a big 24-20 road win over the Kansas City Chiefs in Week 6 as 2.5-point underdogs. Buffalo has won 3 games in a row, and a balanced offense has been alongside a stout defense in those 3 games and throughout the season.

Also see: All Week 8 odds and lines

The Bills have passed for 290 yards or more in 5 of 6 games and have run for more than 100 yards in all 6 affairs. Buffalo leads the NFL in scoring defense (13.5 points allowed per game) and total defense (281.5 yards allowed per game).

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Packers at Bills odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:50 a.m. ET.

  • Moneyline: Packers +410 (bet $100 to win $410) | Bills -600 (bet $600 to win $100)
  • Against the spread (ATS): Packers +10.5 (-112) | Bills -10.5 (-108)
  • Over/Under (O/U): 47.5 (O: -110 | U: -110)

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2022 betting stats

  • ML: Packers 3-4 | Bills 5-1
  • ATS: Packers 2-5 | Bills 4-1-1
  • O/U: Packers 3-4 | Bills 1-5

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Packers vs. Bills head-to-head

Green Bay and Buffalo are meeting on the gridiron for the first time since 2018. The Packers won that game 22-0, but the Bills lead the all-time series 8-5.

Four meetings since 2006 have netted 2 ATS wins a side and a 4-0 mark for the Under.

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