Orlando City SC vs. Inter Miami CF odds, picks and predictions

Analyzing Wednesday’s Orlando City SC vs. Inter Miami CF odds and lines, with expert MLS picks, predictions and best bets.

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Orlando City SC (3 wins, 3 draws, 5 losses) welcomes Inter Miami CF (8-3-2) to Inter&Co Stadium Wednesday. Kickoff is set for 7:30 p.m. ET. Below, we preview FanDuel Sportsbook’s lines around the Orlando City SC vs. Inter Miami CF odds, and make our best expert MLS picks and predictions.

Orlando City sits 11th in the Eastern Conference and has a -6 goal differential through 11 games, having scored 14 and allowed 20. City is coming off an impressive 3-2 road win over the Philadelphia Union Saturday despite having 2.6 fewer expected goals. Orlando City snapped a 2-game losing streak with the win. It is 1-2-3 at home this season and is led by F Duncan McGuire, who has netted 5 goals in 10 matches.

With F Lionel Messi leading the charge, Inter Miami is the hottest team in the MLS and has rattled off 5 straight victories. Inter has won 3 in a row on the road and has scored at least 3 goals in 5 consecutive games. It is 7-1-0 in the 8 games captained by Messi. Former Barcelona teammate F Luis Suarez leads the team in scoring with 11 goals in 12 matches. Inter is 4-1-1 on the road this season.

Messi might now play Wednesday, however. He is listed as questionable after suffering a minor knee injury in Saturday’s 3-2 win over Montreal.

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Orlando City SC vs. Inter Miami CF odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:12 a.m. ET.

  • Moneyline: Orlando City SC +155 (bet $100 to win $155) | Inter Miami CF +145 (bet $100 to win $145) | Draw +270
  • Over/Under: 3.5 (O: +134 | U: -162)

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Orlando City SC vs. Inter Miami CF picks and predictions

Prediction

Inter Miami 3, Orlando City 2

Moneyline (ML)

This comes down to if Messi plays or not. If he does, jump on INTER MIAMI (+145). Before Tuesday’s injury report was released with Messi questionable, Inter Miami’s odds were +115.

Inter has been on fire as of late. Messi is putting together an all-time great season with 10 goals and 10 assists, and Suarez has been just as competent in front of goal. While many of Inter’s last 4 wins aren’t overly impressive, one of them was a 6-2 slaughtering at home against the New York Red Bulls, who sit 3rd in the East.

City might have won Saturday, but it has had fewer expected goals in 3 straight games, 2 of which were at home. City lost 2 straight at home, falling to Toronto FC and FC Cincinnati.

If he plays, expect Messi and company to keep its streak alive and back INTER MIAMI (+145). If he doesn’t play, bet a half unit on Miami.

Over/Under (O/U)

LEAN OVER 3.5 (+134).

Orlando City has allowed at least 1.5 expected goals in 5 of its last 6 games. City has given up 2 goals in 4 of its last 5. Welcoming arguably the best offense in the MLS, Orlando may struggle to keep Inter Miami at bay. City has even gone Over this total in 3 of its last 5 games.

Inter has topped this total in 6 straight matches, scoring at least 3 straight in 5 games and allowing at least 2 in 4 of its last 6. It hasn’t had a clean sheet since March 2.

Expect a high-scoring battle and take OVER 3.5 (+134).

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