Notre Dame at Purdue odds, picks and predictions

Analyzing Saturday’s Notre Dame at Purdue odds and lines, with college football expert picks, predictions and best bets.

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The Notre Dame Fighting Irish (1-1) travel to meet the Purdue Boilermakers (1-0) Saturday at Ross-Ade Stadium in West Lafayette, Ind. Kickoff is scheduled for 3:30 p.m. ET (CBS/Paramount+). Let’s analyze BetMGM Sportsbook’s college football odds around the Notre Dame vs. Purdue odds, and make our expert college football picks and predictions.

The Fighting Irish tumbled from No. 7 to No. 19 in the Coaches Poll after a stunning loss at home to Northern Illinois of the MAC last weekend. Notre Dame suffered the embarrassing 16-14 loss as a 28-point favorite, the biggest upset of the 2024 college football season so far.

The Irish have managed 18.5 points per game (PPG), while allowing 14.5 PPG, cashing the Under in each outing, while splitting 1-1 against the spread (ATS).

Purdue has played just once, routing FCS Indiana State 49-0 at Ross-Ade on Aug. 31, covering as a 35-point favorite. There isn’t a lot to glean from a beatdown of an FCS team, although the Boilermakers did take care of business, while allowing just 104 rushing yards, and 50 passing yards, while winning via rout despite a minus-1 turnover ratio.

The Boilermakers had 248 yards on the ground, and 335 yards through the air, while getting to the quarterback for 3 sacks. Purdue had 11 penalties for 110 yards, an area it must clean up.

Notre Dame leads this series 57-26-2, and it hasn’t lost to Purdue since 2007, officially winning 6 straight in the series. Wins in 2012-13 were vacated.

US LBM Coaches Poll: Conducted by the American Football Coaches Association and USA TODAY Sports

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Notre Dame at Purdue odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Friday at 7:12 p.m. ET.

  • Moneyline (ML): Notre Dame -300 (bet $300 to win $100) | Purdue +240 (bet $100 to win $240)
  • Against the spread (ATS): Notre Dame -7.5 (-110) | Purdue +7.5 (-110)
  • Over/Under (O/U): 47.5 (O: -110 | U: -110)

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Notre Dame at Purdue picks and predictions

Prediction

Notre Dame 23, Purdue 19

Moneyline

Notre Dame (-300) is a super risky play going on the road after a major upset last weekend. However, it’s hard to imagine that the Fighting Irish didn’t have a hellish week of practice, working on all of the things it needs to correct, and then some.

QB Riley Leonard was a disaster against NIU, and the jury is still out on whether he can be the guy. In addition, he suffered an injury to his non-throwing shoulder against the Huskies, so there is doubt he can even go. Either QBs Steve Angeli or CJ Carr would start, if Leonard can’t start.

If we saw more than 1 game from Purdue (+240), and it was a good win over an FBS team, not a dress rehearsal against an FCS foe, we might have more confidence suggesting an upset.

PASS.

Against the spread

Back PURDUE +7.5 (-110) with the 7 and a hook. In fact, that half-point might come in super handy. We don’t know much about the Boilermakers, but what we saw was impressive.

However, Notre Dame -7.5 (-110) just cannot be trusted. Not only did it lose last week to a MAC team as a favorite of 4 TDs, but the Fighting Irish have questions under center, whether Leonard is able to play or not.

Over/Under

UNDER 47.5 (-110) is worth a look.

The Boilermakers pitched a shutout against its 1st opponent, albeit a lower-division school, while the Fighting Irish have had problems generating offense. Notre Dame has looked pretty good defensively against Texas A&M and NIU, though, and if it rebounds this week, it will be because it leaned into its D.

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First look: Notre Dame at Purdue odds and lines

Looking at Saturday’s Notre Dame at Purdue college football odds, lines and trends. Here’s what you need to know.

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The No. 19 Notre Dame Fighting Irish (1-1) take on the Purdue Boilermakers (1-0) Saturday at Ross-Ade Stadium. Kickoff is set for 3:30 p.m. (CBS). Below, we look at Notre Dame vs. Purdue odds from BetMGM Sportsbook before making our expert college football picks and predictions later in the week.

The Fighting Irish were laid to rest by the Northern Illinois Huskies 16-14 last weekend. Notre Dame was a 28-point favorite in the setback and fell more than 10 spots in the Coaches Poll. QB Riley Leonard had a dreadful game, going 20-for-32 for 163 yards, 0 TDs and 2 INTs.

Purdue put its feet up in a 49-0 shellacking of the Indiana State Sycamores Aug. 31. QB Hudson Card was immaculate, going 24-for-25 for 273 yards and 4 TDs. The Boilers had the week off before welcoming the Irish to town.

Notre Dame is No. 19 in the US LBM Coaches Poll.

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Notre Dame at Purdue odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:15 a.m. ET.

  • Moneyline (ML): Notre Dame -500 (bet $500 to win $100) | Purdue +360 (bet $100 to win $360)
  • Against the spread (ATS): Notre Dame -12.5 (-110) | Purdue +12.5 (-110)
  • Over/Under (O/U): 45.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: Notre Dame 1-1 | Purdue 1-0
  • ATS: Notre Dame 1-1 | Purdue 1-0
  • O/U: Notre Dame 0-2 | Purdue 0-1

Notre Dame vs. Purdue head-to-head

Notre Dame has won 8 straight meetings against Purdue, dating back to 2008. Their last clash came in 2021, when the Irish won 27-13, covering as 7.5-point favorites at home.

Purdue hasn’t beaten the Irish since Sept. 29, 2007, when Irish QB Jimmy Clausen split snaps with QB Evan Sharpley.

Play our free daily Pick’em Challenge and win! Play now!

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Ryan Dodson on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:
Alabama / Arkansas / Auburn / Clemson / Colorado / DukeFlorida / Florida StateGeorgia / Iowa / KentuckyLSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / UCLA / USC / WashingtonWisconsin / Recruiting / Transfer portal / College Football Playoffs / College Sports Wire / High School

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