The 2021 NFL season gets underway Thursday, Sept. 9, with an 8:20 p.m. ET kickoff between the Dallas Cowboys and reigning Super Bowl champion Tampa Bay Buccaneers. Want some betting action on the opening slate? Below, we look at the Week 1 NFL odd and lines; check back for our NFL picks and predictions.
The Kansas City Chiefs head into the 2021 season as favorites to win Super Bowl LVI after playing in each of the last two championship games. Tampa Bay is second by the odds after winning Super Bowl 55. The entire league will enjoy a week off after a three-week preseason before beginning the NFL’s first 17-game regular season
Odds provided by Tipico Sportsbook and last updated Monday, Aug. 30.
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