New York Giants vs. San Francisco 49ers odds predictions pick betting line spread

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The New York Giants (1-1) battle the San Francisco 49ers (2-0) on Thursday Night Football. Kickoff from Levi’s Stadium is set for 8:15 p.m. ET (Prime Video). Below, we analyze BetMGM Sportsbook’s lines around the Giants vs. 49ers odds, and make our expert NFL picks and predictions.

After a 40-0 loss in the opener, the Giants extended their scoreless streak to 6 quarters and trailed the Arizona Cardinals 20-0 at the half on Sunday. New York scored 31 points in the 2nd half to win 31-28, but failed to cover as 5-point favorites. QB Daniel Jones finished 26 of 37 for 321 yards with 2 TDs and an interception. S Jason Pinnock showed out on defense with 13 total tackles, including 10 solos and 3 tackles for loss.

San Francisco took down the Los Angeles Rams last week with a 30-23 road victory to push as 7-point favorites. RB Christian McCaffrey led the way on offense with 20 carriers for 116 yards and a TD while tacking on 3 receptions for 19 yards.

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Giants at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 9:41 p.m. ET.

Moneyline (ML): Giants +400 (bet $100 to win $400) | 49ers -550 (bet $550 to win $100)
Against the spread (ATS): Giants +10 (-110) | 49ers -10 (-110)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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Giants at 49ers key injuries

Giants

RB Saquon Barkley (ankle) out
G Ben Bredeson (concussion) out
LB Micah McFadden (neck) questionable
DE Azeez Ojulari (hamstring) out
WR Wan’Dale Robinson (knee) questionable
T Andrew Thomas (hamstring) out

49ers

WR Brandon Aiyuk (shoulder) questionable
CB Ambry Thomas (knee) questionable

Giants at 49ers picks and predictions

Prediction

49ers 31, Giants 17

Moneyline

PASS.

At -550 odds, there is no profit to be made betting on the 49ers to win at home. They have looked dominant on both sides of the ball so far this year outscoring opponents 60-30. Expect more of the same Thursday night.

Against the spread

LEAN 49ERS -10 (-110).

As seen above, the Giants enter Thursday beaten up. Missing multiple starters on their defense, while facing a potential MVP in McCaffrey, it will be difficult for New York to get crucial stops. Even with Aiyuk possibly sidelined, QB Brock Purdy has multiple weapons that he will be able to locate and extend San Fran’s lead allowing them to cover.

New York will have to come out with a bang. If they find themselves in a hole similar to that of last week, there will be no opportunity for them to climb out.

Over/Under

BET OVER 44.5 (-110).

Primarily, many of the points will come from San Francisco and its offense. They find many different ways to spread the ball and keep the defense on their toes. Through 2 weeks of play, the Niners have 4 TDs on the ground and 2 TDs through the air. What may allow the Giants to score is gaining critical field position with the Niners tendency to turn the ball over. In their 2 games, they have fumbled the ball 6 times.

The Giants demonstrated in the 2nd half last week their potential to put points on the board. For that reason, the Over is the best choice in this game.

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Tag: New York Giants vs. San Francisco 49ers odds predictions pick betting line spread

New York Giants at San Francisco 49ers odds, picks and predictions