NFL Week 16 parlay: Let’s make some money

Analyzing NFL Week 16 betting odds and lines, with predictions and picks for the best parlay bet to make.

We’re looking to finish off this wacky 2022 season strong. Let’s try to give ourselves an early Christmas present with a Saturday parlay win to cap off the holiday festivities. After looking at Tipico Sportsbook’s NFL Week 16 odds, here’s our “Let’s make some money” NFL parlay bet to cash in on among SportbookWire’s NFL expert picks and predictions.

There are a lot of teams with plenty to play for in Week 16 of the NFL season. There are plenty of storylines to follow and there is plenty of money to be made. Finding the intersection between the 2 points will be the key to finding some good plays to wager on.

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NFL Week 16: Let’s make some money parlay

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated on Thursday at 12:08 a.m. ET. All games Saturday and ET unless noted.

Leg 1: LIONS -2.5 (-118) at Panthers – 1 p.m. (FOX)

The Lions have the 31st ranked defense in the NFL, but the defense has played better in recent weeks and the offense has been solid all season.

Jared Goff has set himself up as the QB for Detroit in 2023 with the way he has meshed with WR Amon-Ra St. Brown. With the offensive line blocking great for D’Andre Swift and Jamaal Williams, the Lions are on the verge of making the playoffs. The team has already gone over its win total of 6.5 for the season.

Carolina is still alive in the NFC South, but has a lot of ground to make up and not a talented roster to do it with. While this game will be close early, the Lions will pull away and win by more than a field goal.

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Leg 2: Giants at Vikings OVER 48 (-111) – 1 p.m. (FOX)

This is an important spot for both teams. Saquon Barkley is coming off a good game on Sunday night and the Vikings are coming off an incredible 33-point comeback victory against the Indianapolis Colts on Saturday. Dalvin Cook, Justin Jefferson and Adam Thielen will be able to put up points in this game. The Vikings defense will also give up points to the Giants. While 48 is much higher then the other over I am on in this parlay, I like this game to get to about 55. Both teams need this game for their playoff seeding and it will be important for both. Expect the offenses to come out humming.

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Leg 3: Saints at Browns OVER 32.5 (-109) – 1 p.m. (CBS)

The total of this game is the lowest total in an NFL in over a decade. The weather will be around -10 and it will be snowy and windy. This means the run game will be important. Saints RB Alvin Kamara will be up for the challenge and if Nick Chubb comes back to practice and is able to play for the Browns, I can see 5 TD being scored in this game.

I do not think it will be a shootout in the 40’s for each team. But all I am asking for is a 20-14 game. I think this is viable. Even in the tough conditions which will be had in Cleveland.

Parlay payout: Bet $10 to win $66.40 (profit $56.40).

Try out the USA TODAY Parlay Calculator.

Leg 4-*: Texans at TITANS -3 (-116) – 1 p.m. (CBS)

*-If you want to add a 4th play to this parlay:

Derrick Henry and the Titans love to play against the Texans. This game will be even better for the Titans as the Texans will be without RB Dameon Pierce and WRs Brandin Cooks and Niko Collins. The Texans have not given up, but they might as well have. The Titans will finally be able to get off their 4-game slide when they play at home in this game. Even without Ryan Tannehill, QB Malik Willis and Henry can do enough to win this battle of AFC South teams.

Parlay payout: Bet $10 to win $126.90 (profit $116.90).

More NFL Week 16 picks and predictions

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