New Orleans Saints at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s New Orleans Saints at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (0-1) welcome the New Orleans Saints (1-0) to Levi’s Stadium Sunday. Kickoff is set for 8 p.m. ET (FOX). Below, we analyze FanDuel Sportsbook’s lines around the Saints vs. 49ers odds, and make our expert NFL picks and predictions.

The 49ers, among the best teams in the NFL over the last few seasons, lost its preseason opener to the Tennessee Titans 17-13. Backup QB Joshua Dobbs passed for 146 yards and an INT. First-round draft pick WR Ricky Pearsall  didn’t have a catch in the 1st preseason game.

New Orleans won its preseason opener 16-14 over the Arizona Cardinals. Starting QB Derek Carr went 2-of-6 for 12 yards.

Saints at 49ers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:38 a.m. ET.

  • Moneyline (ML): Saints +100 (bet $100 to win $100) | 49ers -120 (bet $120 to win $100)
  • Against the spread (ATS): Saints  +1.5 (-110) | 49ers -1.5 (-110)
  • Over/Under (O/U): 38.5 (O: -115 | U: -105)

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Saints at 49ers picks and predictions

Prediction

49ers 20, Saints 17

Moneyline

BET 49ERS (-120).

The 49ers being in front of their own fans should help. The better case here is the fact the starters may get a few series which should result in points, and the backups are experienced quarterbacks in Dobbs and QB Brandon Allen.

The Saints backups are more of a wild card in QB Spencer Rattler. New Orleans may have beaten Arizona, but they were 5-of-15 on 3rd down and committed 9 penalties. Those shortcomings will be tough to overcome against San Francisco.

Given those preseason issues for New Orleans, take 49ERS (-120).

Against the spread

PASS.

Given how similar the spread and moneyline are, avoid the added risk and take the home team’s moneyline play. While not a bad option for bettors, avoid this play and look above.

Over/Under

BET UNDER 38.5 (-105).

Neither team’s 2nd unit looked overly impressive in their 1st outing. The Saints gained just 286 total yards and were not great in sustaining drives.

The 49ers scored just 13 points, and their QBs combined to go 21-of-33. San Francisco was just 4-for-11 on 3rd down as well and 0-for-2 on 4th down.

Both teams held their opponent to 17 or fewer. Given those trends, take UNDER 38.5 (-105).

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New Orleans Saints at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s New Orleans Saints at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The New Orleans Saints (4-7) look to snap a 3-game road losing streak when they meet the San Francisco 49ers (6-4) Sunday at 4:25 p.m. (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Saints vs. 49ers odds, and make our expert NFL picks and predictions.

The Saints won last week with a 27-20 win over the punchless Rams to keep them with sniffing distance of 1st place in the eminently mediocre NFC South – where 4-7 still makes you a contender.

The 49ers started the season 3-4, but have hit their stride once running back Christian McCaffrey has been incorporated into the offense. Their physical style on both sides of the ball is starting to click on all cylinders, highlighted by a 38-10 bludgeoning of division-rival Arizona Monday night in Mexico City.

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Saints at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:45 a.m. ET.

  • Moneyline (ML): Saints +350 (bet $100 to win $350) | 49ers -425 (bet $425 to win $100)
  • Against the spread (ATS): Saints +8.5 (-109) | 49ers -8.5 (-111)
  • Over/Under (O/U): 43 (O: -112 | U: -108)

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Saints vs. 49ers key injuries

Saints

  • DE Marcus Davenport (calf) questionable
  • RB Mark Ingram (knee) questionable
  • DE Cameron Jordan (eye) questionable
  • CB Marshon Lattimore (abdomen) questionable
  • OL Andrus Peat (triceps) questionable
  • LB Pete Werner (ankle) out

49ers

  • DL Arik Armstead (foot, ankle) doubtful
  • WR Deebo Samuel (hamstring) questionable

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Saints vs. 49ers picks and predictions

Prediction

49ers 31, Saints 17

Moneyline

PASS.

The Niners should be to take care of their business and giving away a 4.5 rate of return doesn’t make sense.

Against the spread

BET 49ERS -8.5 (-111).

The Saints had 9 key players that either missed or were limited in practice due to injuries this week. Nobody is injury-free at this point in the season, but that is an excessive number for a team going on the road to face one of the hotter teams in the league.

The 49ers are built to lay a ton of points, and the Saints’ last 2 losses have been by 14 and 10 points. When San Francisco wins, they almost always win big – their 6 wins this season have come by 20, 15, 22, 17, 6 and 28 points.

If you can’t match the 49ers physicality, they beat you into submission. This looks like a scenario likely to play out again for the banged-up Saints.

Over/Under

OVER 43 (-112) is the way to go.

The 49ers have scored 31 or more points in 2 of their last 3 games, and the Saints have scored 24 or more points in 6 of the last 8 games.

The wild card for me is the margin of victory the 49ers have piled up when things are going well. When they get a lead, they don’t go into a shell on either side of the ball. If the Niners score 31, that doesn’t require the Saints to do that much – even in garbage time late – to surpass this number.

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If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

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