Missouri at Vanderbilt odds, picks and predictions

Analyzing Saturday’s Missouri at Vanderbilt odds and lines, with college football expert picks, predictions and best bets.

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The Missouri Tigers (4-0, 0-0 SEC) and the Vanderbilt Commodores (2-3, 0-1) meet Saturday at FirstBank Stadium in Nashville for an SEC East matchup. Kickoff is scheduled for 4 p.m. ET (SEC Network). Below, we analyze FanDuel Sportsbook’s lines around the Missouri vs. Vanderbilt odds, and make our expert college football picks and predictions.

The Tigers cracked into the Top 25 rankings by dropping Kansas State and Memphis in consecutive weeks, while also grabbing covers in those outings. Against non-FBS teams, Mizzou is 0-2 against the spread (ATS), but against Power 5 teams, it is 2-0 ATS. The Over is 3-1 for the Tigers, allowing 19 or more points in 3 games vs. FBS teams.

The Commodores have been anything but a brickhouse, dropping 3 straight games to Kentucky, UNLV and Wake Forest after opening with a pair of wins over Hawaii and Alabama A&M. What’s more, Vandy is 0-5 ATS, while allowing 28 or more points to all 4 FBS opponents. It’s no surprise the Over is 4-0-1 thus far.

Missouri is No. 22 in the US LBM Coaches Poll powered by USA TODAY Sports.

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Missouri at Vanderbilt odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 1:10 a.m. ET.

  • Moneyline (ML): Missouri -500 (bet $500 to win $100) | Vanderbilt +375 (bet $100 to win $375)
  • Against the spread (ATS): Missouri -13.5 (-105) | Vanderbilt +13.5 (-115)
  • Over/Under (O/U): 54.5 (O: -110 | U: -110)

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Missouri at Vanderbilt picks and predictions

Prediction

Missouri 38, Vanderbilt 20

Moneyline

Missouri (-500) will cost you 5 times your potential return, and that’s quite expensive for not nearly enough reward. It’s an especially high price in a divisional conference game, even if the host is a perennial league doormat.

AVOID, and look to the spread instead.

Against the spread

MISSOURI -13.5 (-105) is worth a look after notching covers in consecutive showdowns with K-State and Memphis. While it’s sometimes hard to believe Vanderbilt +13.5 (-115) qualifies, it is a Power 5 team, and the Tigers are 2-0 ATS against such teams so far this season. On the flip side, the ‘Dores are a dismal 0-5 ATS, and that doesn’t appear to be changing anytime soon.

Know that you’ll be going against some trends, as Vandy is actually 4-1 ATS in the previous 5 meetings, including a 17-14 near-miss in Columbia last season. However, Mizzou has won 6 of the past 7 meetings straight up, and 2 of those victories has been by 28 or more points, including a trip to Nashville in 2017.

Over/Under

OVER 54.5 (-110) is the best option on the board.

Both of these teams have been all gas and no brakes on offense, while playing very little defense.

Mizzou has racked up 30 or more points in 3 of its 4 games, while yielding 27 or more points in both games against Power 5 schools. The Over is 3-1 so far this season.

Vandy has coughed up 36 or more points in each of the past 3 games, while scoring 28 or more points in 4 of 5 outings, going 4-0-1 to the Over in 2023.

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