Missouri at South Carolina odds, picks and predictions

Analyzing Saturday’s Missouri at South Carolina odds and lines, with college football expert picks, predictions and best bets.

The Missouri Tigers (3-4, 1-3 SEC) and the No. 25 South Carolina Gamecocks (5-2, 2-2) play Saturday at Williams-Brice Stadium in Columbia, S.C. Kickoff is scheduled for 4 p.m. ET (SEC Network). Below, we analyze Tipico Sportsbook‘s lines around the Missouri vs. South Carolina odds, and make our expert college football picks and predictions.

The Tigers snapped a 3-game losing skid with a 17-14 home win last week against Vanderbilt as 13.5-point favorites. While Mizzou is under .500, 2 of the 3 losses during the skid were one-score games, including a 4-point loss against No. 1 Georgia.

The Tigers were 3-0 ATS during the losing streak but failed to cover in the win against Vandy.

The Gamecocks have rolled up 4 consecutive victories as the defense has stepped up its play. USC’s offense has always been there, going for 30 or more points in 5 of 7 games this season. But the D, after allowing 35.3 PPG in the first 3 games has allowed just 17.0 PPG across the past 4 outings.

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Missouri at South Carolina odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 8 a.m. ET.

  • Moneyline (ML): Missouri +145 (bet $100 to win $145) | South Carolina -180 (bet $180 to win $100)
  • Against the spread: Missouri +3.5 (-122) | South Carolina -3.5 (-102)
  • Over/Under (O/U): 45.5 (O: -112 | U: -108)

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Missouri at South Carolina picks and predictions

Prediction

South Carolina 27, Missouri 16

Moneyline

SOUTH CAROLINA (-180) is at my personal limit for a moneyline play as a standalone bet. Lately, the ranked Gamecocks have looked like a different team after early losses at Arkansas and against Georgia. It can lock up bowl eligibility with a win here, and it should easily do just that.

Mizzou has won the past 3 in this series, but Carolina will grab the win here. The last time the Gamecocks won at home against the Tigers was a 37-35 shootout Oct. 6, 2018.

Against the spread

BET SOUTH CAROLINA -3.5 (-102).

Three and a hook isn’t my favorite bet when backing a favorite, but it’s a good play here. Mizzou has been a thorn in the side of teams lately, going 3-1 ATS in the past 4 games overall. However, it is also winless in 3 tries on the road, losing by an average of 12.7 PPG.

Over/Under

UNDER 45.5 (-108) is worth a look, even though this is a low number in this day and age of high-octane college football.

The Under has cashed in 6 straight games for Mizzou, with the Tigers going for 17 or fewer points in 3 of the past 4 outings overall.

While South Carolina has cashed the Over in 3 of the past 4 outings, the Under is 2-0 in its 2 games against SEC East teams this season.

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Missouri at South Carolina odds, picks and prediction

Previewing Saturday’s Missouri Tigers at South Carolina Gamecocks sports betting odds and lines, with college football betting picks, tips and predictions.

The South Carolina Gamecocks (2-5) host the Missouri Tigers (2-3) Saturday in an SEC showdown at Williams-Brice Stadium. The kickoff is scheduled for 7:30 p.m. ET. Below, we analyze the Missouri-South Carolina college football betting odds and lines, with picks and predictions.

Missouri at South Carolina: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 3:40 p.m. ET.

  • Money line: Missouri -228 (bet $228 to win $100) | South Carolina +185 (bet $100 to win $185)
  • Against the spread/ATS: Missouri -6 (-110) | South Carolina +6 (-110)
  • Over/Under: 57.5 (O: -110 | U: -110)

Missouri at South Carolina: Three things to know

  1. The last time Missouri played was on Halloween and the Tigers were blown out 41-17 by Florida. Missouri’s last game against Georgia was canceled due to a COVID-19 outbreak on its roster. This is the first game Missouri has been favored in all season and the Tigers are 3-2 against the spread this year.
  2. South Carolina fired head coach Will Muschamp and promoted offensive coordinator Mike Bobo to interim head coach following a 59-42 loss at Ole Miss Nov. 14. It was the Gamecocks’ third consecutive loss, both outright and against the spread.
  3. The Tigers snapped a three-game losing streak against the Gamecocks last season with a 34-14 win in which they covered the spread as 10.5-point home favorites. The home team is 4-1 ATS in their last five meetings and the Under is 7-1 in the last eight contests.

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Missouri at South Carolina: Odds, betting lines, predictions and picks

Prediction

Missouri 38, South Carolina 35

Money line (ML)

I know this last week has been a little chaotic for the South Carolina program but no way this Missouri team should be more than a 2-to-1 favorite on the road against a conference opponent.

Missouri has been smoked in both of its road games this season. Also, South Carolina’s change in head coach could give it a boost at home. Based on what I’ve seen, +185 isn’t juicy enough to take the home dog. PASS.

Against the spread (ATS)

Let’s fade the line movement and TAKE SOUTH CAROLINA +6 (-110) for 1 unit. There’s split action on each side in this game (51% of the money is on Missouri and 51% of the bets are on South Carolina), according to Pregame.com.

Hopefully, the promotion of the offensive coordinator to head coach will improve a South Carolina passing game that’s been underwhelming this season. South Carolina senior QB Collin Hill should have some clean pockets with Missouri having a couple of defensive line starters listed on the injury report.

Also, Missouri hasn’t played in three weeks and the Tigers could’ve used the reps because they didn’t look good in their last game.

Over/Under (O/U)

Defense was Will Muschamp’s calling card but South Carolina’s defense has been trash all season. It’s pretty much what led to the firing. South Carolina has given up 30-plus points in five games and its Over/Under record is 5-2 O/U.

The Gamecocks rank 111th in opponent’s passing yards per game and 109th in opponent’s completion percentage. Missouri’s passing attack has been surprisingly good as it ranks 42nd in passing yards and 12th in completion percentage.GIMME OVER 57.5 (-110) for 1 unit.

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