Missouri at South Carolina odds, picks and predictions

Analyzing Saturday’s Missouri at South Carolina odds and lines, with college football expert picks, predictions and best bets.

The Missouri Tigers (3-4, 1-3 SEC) and the No. 25 South Carolina Gamecocks (5-2, 2-2) play Saturday at Williams-Brice Stadium in Columbia, S.C. Kickoff is scheduled for 4 p.m. ET (SEC Network). Below, we analyze Tipico Sportsbook‘s lines around the Missouri vs. South Carolina odds, and make our expert college football picks and predictions.

The Tigers snapped a 3-game losing skid with a 17-14 home win last week against Vanderbilt as 13.5-point favorites. While Mizzou is under .500, 2 of the 3 losses during the skid were one-score games, including a 4-point loss against No. 1 Georgia.

The Tigers were 3-0 ATS during the losing streak but failed to cover in the win against Vandy.

The Gamecocks have rolled up 4 consecutive victories as the defense has stepped up its play. USC’s offense has always been there, going for 30 or more points in 5 of 7 games this season. But the D, after allowing 35.3 PPG in the first 3 games has allowed just 17.0 PPG across the past 4 outings.

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Missouri at South Carolina odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 8 a.m. ET.

  • Moneyline (ML): Missouri +145 (bet $100 to win $145) | South Carolina -180 (bet $180 to win $100)
  • Against the spread: Missouri +3.5 (-122) | South Carolina -3.5 (-102)
  • Over/Under (O/U): 45.5 (O: -112 | U: -108)

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Missouri at South Carolina picks and predictions

Prediction

South Carolina 27, Missouri 16

Moneyline

SOUTH CAROLINA (-180) is at my personal limit for a moneyline play as a standalone bet. Lately, the ranked Gamecocks have looked like a different team after early losses at Arkansas and against Georgia. It can lock up bowl eligibility with a win here, and it should easily do just that.

Mizzou has won the past 3 in this series, but Carolina will grab the win here. The last time the Gamecocks won at home against the Tigers was a 37-35 shootout Oct. 6, 2018.

Against the spread

BET SOUTH CAROLINA -3.5 (-102).

Three and a hook isn’t my favorite bet when backing a favorite, but it’s a good play here. Mizzou has been a thorn in the side of teams lately, going 3-1 ATS in the past 4 games overall. However, it is also winless in 3 tries on the road, losing by an average of 12.7 PPG.

Over/Under

UNDER 45.5 (-108) is worth a look, even though this is a low number in this day and age of high-octane college football.

The Under has cashed in 6 straight games for Mizzou, with the Tigers going for 17 or fewer points in 3 of the past 4 outings overall.

While South Carolina has cashed the Over in 3 of the past 4 outings, the Under is 2-0 in its 2 games against SEC East teams this season.

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