The Mississippi Rebels and Louisville Cardinals open their 2021 regular season Monday at Mercedes-Benz Stadium in Atlanta. Kickoff is scheduled for 8 p.m. ET. Below, we look at the Mississippi vs. Louisville odds and lines; check back for our college football picks and predictions.
The Rebels earned a trip to the Outback Bowl last season despite just a 4-5 regular-season record, but they capped off head coach Lane Kiffin’s first season with a 26-20 win over a very good Indiana side.
The Cardinals won just four of 11 games last season, but did grab victories in two of the final three outings to build some momentum heading into the new season. QB Malik Cunningham is back to lead the way for Louisville.
Mississippi vs. Louisville odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 7:30 a.m. ET.
- Money line: Mississippi -350 (bet $350 to win $100) | Louisville +265 (bet $100 to win $265)
- Against the spread/ATS: Mississippi -10.5 (-108) | Louisville +10.5 (-112)
- Total (Over/Under): 75.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)
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2020 Betting Stats (Regular Season):
- ML: Mississippi 4-5 | Louisville 4-7
- ATS: Mississippi 4-5 | Louisville 5-5-1
- O/U: Mississippi 6-3 | Louisville 7-4
Mississippi vs. Louisville head-to-head
These two institutions meets on the gridiron for the first time. Ole Miss faces an ACC team for the first time since a 45-34 neutral-site loss to Florida State Sept. 5, 2016. Meanwhile, Louisville faces and SEC school for the first time since a 38-28 win over Mississippi State Dec. 30, 2019, in the Music City Bowl.
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