Divisional Round: Minnesota Vikings at San Francisco 49ers odds, picks and best bets

Previewing Saturday’s NFC Divisional Round showdown between the Minnesota Vikings and San Francisco 49ers, with betting odds, picks and bets.

The Minnesota Vikings (11-6) are coming off an overtime playoff road win to face a well-rested, top-seeded San Francisco 49ers (13-3) at Levi’s Stadium at 4:35 p.m. ET Saturday. We analyze the Vikings-49ers odds and sports betting lines, while providing betting tips and advice on this Week 17 NFL matchup.

Vikings at 49ers: Divisional Round preview, betting trends and notes


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  • The total has hit the Over in five of Minnesota’s last six road games.
  • The total has hit the Over in seven of San Francisco’s last 10 games.
  • Minnesota is 7-3 against the spread in its last 10 games against NFC opponents.
  • Both teams have had their fair share of success. The Vikings have the seventh ranked scoring offense (25.5 points per game) and the sixth ranked scoring defense (19 PPG). Not to be outdone, the 49ers are second in scoring offense (29.9 PPG) and the eighth in scoring defense (19.4 PPG).
  • The 49ers are just 9-6-1 against the spread, including 3-4-1 at home.
  • The Vikings are 10-7 ATS, including 5-4 on the road.
  • The all-time record between the Vikings and 49ers is 23-23-1, but Minnesota has won six of the last eight.

Vikings at 49ers: Key injuries

Vikings: CB Mackensie Alexander (knee) is out and CB Mike Hughes was placed on IR last week. WR Stefon Diggs hasn’t practiced due to an illness, but is expected to play. S Jayron Kearse (toe/knee) and WR Adam Thielen (ankle) are questionable.

49ers: Everyone practiced Wednesday, but DEs Dee Ford (quadriceps/hamstring) and Kentavius Street (knee) and G Mike Person (neck) were limited.

Vikings at 49ers: Odds, betting lines and prediction

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 2:45 a.m. ET.

Prediction

49ers 24, Vikings 20

Moneyline (?)

Minnesota (+260) has a prohibitive moneyline number and could have a legitimate shot at winning the game outright. San Francisco (-334) is giving up too much for a return. If you’re betting the moneyline, a small bet on the Vikings would be the play, but, if you’re betting the 49ers, a stronger bet would be to give up 3.5 points at -189.

Against the Spread (?)

The Vikings likely aren’t capable of blowing out the 49ers. A rested San Francisco team going up against a Minnesota squad that had a short week of practice after playing an overtime game on the road Sunday and flying back to Minnesota is a scenario fraught with the potential for a Niners blowout. But, Minnesota could be down by 14 late and score a meaningless touchdown to hit the number. Realistically, the Niners need to win by two scores. Take the VIKINGS +7 (-110).

Over/Under (?)

The O/U is of 45.5 (Over +105, Under -129). This is a tough one because these are two of the best rush offenses and two of the better defenses. This game could – and likely will – include its share of punts with it being a field-position battle. Minnesota has allowed 23 or fewer points 13 times this season and San Francisco has a knack for protecting leads by shortening the game. Take the UNDER 45.5 (-129).

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