Minnesota Vikings vs. Buffalo Bills odds predictions pick betting line spread

Minnesota Vikings at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Minnesota Vikings at Buffalo Bills odds and lines, with expert NFL picks, predictions and best bets.

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The Minnesota Vikings (7-1) ride a 6-game winning streak as they go on the road to face the Buffalo Bills (6-2) at 1 p.m. Sunday at Highmark Stadium (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Vikings vs. Bills odds, and make our expert NFL picks and predictions.

The Bills could be without QB Josh Allen. The line dropped from the Bills favored by 9.5 points down to 3.5 points in the span of 1 hour Wednesday, but their odds have since become shorter.

If Allen can’t go, backup Case Keenum will face his former team. Keenum’s career highlight was the playoff Minneapolis Miracle win over New Orleans in January 2018. The miracle was a game-ending touchdown pass to Stefon Diggs when both were Vikings and got to the NFC Championship Game. Now both are Bills.

This is the 1st time Diggs has played Minnesota since being traded to Buffalo. The Vikings used the pick traded from the Bills to draft Justin Jefferson – a trade that has worked out immensely for both teams. Look for Diggs and Jefferson to be the focus of both offenses in this game of revenge and star talent.

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Vikings at Bills odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 4:50 p.m. ET.

Moneyline (ML): Vikings +235 (bet $100 to win $235) | Bills -280 (bet $280 to win $100)
Against the spread (ATS): Vikings +6.5 (-114) | Bills -6.5 (-106)
Over/Under (O/U): 44.5 (O: -108 | U: -112)

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Vikings at Bills key injuries

Vikings

CB Cameron Dantzler (ankle) out
DT Dalvin Tomlinson (calf) out

Bills

QB Josh Allen (elbow) questionable
LB Tremaine Edmunds (groin/heel) questionable
CB Kaiir Elam (ankle) doubtful
S Jordan Poyer (elbow) out
DE Greg Rousseau (ankle) out

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Vikings at Bills picks and predictions

Prediction

Bills 31, Vikings 20

Moneyline

PASS

If I was going to make a bet on this, I would place a small wager on the Vikings getting almost 3:2 on the investment. Yet, given the unique circumstances noted above for Allen to miss his first game as a starter since 2018, it’s still not enough to convince me to make a bet on the underdog here.

Against the spread

TAKE THE BILLS -6.5 (-110)

My initial projection on this game was 38-17 Bills before the news because Minnesota always struggles with scrambling quarterbacks.

While the Bills have several key injuries beyond Allen (3 defensive starters and their 1st-round draft pick of 2022), Buffalo has built itself to be a Super Bowl contender by building depth through the draft and free agency.

Not having Allen would significantly alter my projection but not enough to jump off the bandwagon completely.

Over/Under

TAKE THE OVER 44.5 (-108)

This is where defensive injuries for both teams are going to impact this line. The Bills will be without their best pass rusher, an All-Pro safety and their middle linebacker is a question mark. Meanwhile, the Vikings will be without their best run-stuffer and a starting cornerback.

A storyline heading into this one will be that both teams benefited from the trade that sent Diggs to Buffalo, and I believe both Diggs and Jefferson are going to have big days by force of playcalling and design.

It may take until deep into the 4th quarter to hit the Over, but both teams are capable of scoring 27 points, which doesn’t leave a lot for the loser to have to accomplish to surpass this point.

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First look: Minnesota Vikings at Buffalo Bills odds and lines

Looking at Sunday’s Minnesota at Buffalo Week 10 NFL odds, lines and trends. Here’s what you need to know.

The Minnesota Vikings (7-1) travel to Orchard Park to battle the Buffalo Bills (6-2) Sunday at 1 p.m. ET (FOX). Below, we look at Vikings vs. Bills odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

Both teams come into this game after struggling on the road Sunday. The Vikings were able to come out with a 20-17 victory over the Washington Commanders while the Bills lost to the New York Jets by the same 20-17 score.

The struggle of the Bills was more surprising as Josh Allen and his 2 TD runs were the only offense Buffalo was able to generate against the New York Jets.

The Vikings have had some difficulties both outdoors and on the road. The Commanders were able to bottle up Kirk Cousins, making his first return to Washington since leaving to sign with Minnesota, and the Vikings offense for most of the game. That could happen again Sunday as the Bills bring the best scoring defense in the NFL to this game.

Also see: All Week 10 odds and lines

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Seahawks vs. Buccaneers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:29 p.m. ET.

Moneyline (ML): Vikings +215 (bet $100 to win $215) | Bills -280 (bet $280 to win $100)
Against the spread (ATS): Vikings +6.5 (-110) | Bills -6.5 (-110)
Over/Under (O/U): 46 (O: -110 | U: -110)

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2022 betting stats

ML: Vikings 7-1 | Bills 6-2
ATS: Vikings 3-4-1 | Bills 4-3-1
O/U: Vikings 4-4 | Bills 1-7

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Vikings vs. Bills head-to-head

These teams have only played once in recent years, a 27-6 victory by the Bills in 2018. Buffalo won by 21 despite coming into the game as 16.5-point underdogs.

Both teams have changed vastly since then. Both offenses are at a different level and both defenses have also improved. This will be a matchup between 2 of the best teams in the NFL this season.

Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

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