Michigan at Indiana odds, picks and predictions

Analyzing Saturday’s Michigan at Indiana odds and lines, with college football expert picks, predictions and best bets.

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The Michigan Wolverines (5-4, 3-3 Big Ten) and the No. 10 Indiana Hoosiers (9-0, 6-0) meet Saturday at Memorial Stadium in Bloomington. Kickoff is scheduled for 3:30 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s college football odds around the Michigan vs. Indiana odds, and make our expert college football picks and predictions.

Michigan dropped its third game in the last 4 outings, losing 38-17 to the No. 1 Oregon Ducks. They failed to cover the 14.5-point spread  and the Over (45) cashed. QB Davis Warren had his best showing this season, completing 12-of-21 passes for 164 yards and 2 TD with TE Colston Loveland hauling in 7 catches for 112 yards.

Indiana kept its perfect season intact with a 47-10 blowout of the Michigan State Spartans, easily covering the 7.5-point spread as the Over (53.5) hit. QB Kurtis Rourke threw for 263 yards and 4 TDs, connecting twice with WR Elijah Sarrett. Indiana’s defense stifled the Spartans, holding them to -36 rushing yards in East Lansing.

– US LBM Coaches Poll: Conducted by the American Football Coaches Association and USA TODAY Sports

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Michigan at Indiana odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated at Friday at 6:21 a.m. ET.

  • Moneyline (ML): Michigan +450 (bet $100 to win $450) | Indiana -650 (bet $650 to win $100)
  • Against the spread (ATS): Michigan +14.5 (-115) | Indiana -14.5 (-105)
  • Over/Under (O/U): 49.5 (O: -110 | U: -110)

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Michigan at Indiana picks and predictions

Prediction

Indiana 38, Michigan 20

Moneyline

PASS.

Indiana (-650) will win this game, but I’m not going to bet $650 to win $100 in return. I’ll take my bet to the spread.

Against the spread

BET INDIANA -14.5 (-115).

It’s hard to believe Indiana is a 2-TD favorite over Michigan, but they’ve earned it. The Hoosiers have excelled against the spread in 2024, covering in 8 of 9 games overall and 4 of 5 at home. Their only ATS home loss came in Week 1, a 31-7 victory over Florida International as a 25.5-point favorite. Indiana’s offense ranks in the top 10 in average yards per game (476.2), a stark contrast to Michigan’s near-bottom standing (299.4 YPG).

Defensively, Indiana is equally impressive, with a top-10 ranking in yards allowed (72.6 per game). Meanwhile, Michigan has struggled, failing to cover in 7 of 9 games, including both road matchups. Offensive production has been a challenge for Michigan, scoring over 17 points only once in their last 4 games. Indiana’s strong all-around performance makes them clear favorites in this matchup.

Over/Under

BET OVER 49.5 (-110).

Expect a high-scoring game on Saturday, despite Indiana’s stout defense and Michigan’s woefuloffense. Michigan has scored over 30 points in each of their last 3 matchups with the Hoosiers, including 52 points in their October meeting last year.

Indiana, with its top-10 ranked offense, is capable of quick and high-scoring bursts. They’ve gone Over the point total in 2 of their last 3 home games and 7 of 8 overall. Michigan, too, has hit the Over in 5 of 6 games, allowing 21+ points in both road contests this season.

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Michigan at Indiana odds, picks and prediction

Previewing Saturday’s Michigan Wolverines at Indiana Hoosiers sports betting odds and lines, with college football betting picks, tips and predictions.

The Michigan Wolverines (1-1 overall, 1-1 Big Ten) pay a visit to Bloomington, Ind., to take on the Indiana Hoosiers (2-0, 2-0). The Saturday battle at Memorial Stadium is slated for a noon ET kickoff. We analyze the Michigan-Indiana college football betting odds and lines, with picks and predictions.

The Hoosiers are ranked No. 13 in the Amway Coaches Poll powered by USA TODAY Sports. The Wolverines are ranked No. 25.

Michigan at Indiana: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4 p.m. ET.

  • Money line: Michigan -150 (bet $150 to win $100) | Indiana +125 (bet $100 to win $125)
  • Against the spread/ATS: Michigan -2.5 (-121) | Indiana +2.5 (+100)
  • Over/Under: 54.5 (O: -110 | U: -110)

Michigan at Indiana: Three things to know

  1. HC Jim Harbaugh‘s Michigan teams are just 10-15 against ranked teams. That mark includes an odd caveat: five of those wins have been blowouts, with UM winning by an average 31 points. Under HC Tom Allen, Indiana is 1-13 against ranked opponents; the lone win in that record came against Penn State two weeks ago.
  2. Indiana averaged just 3.6 yards per rushing attempt in 2019. So far this fall, things have been even worse. In two games, the Hoosiers have run the ball 66 times for 150 yards (2.9 average).
  3. The Hoosiers already have five interceptions in 2020; that’s just two less than they had in a full season a year ago. In two games, Indiana has registered five picks and nine pass break-ups. That IU secondary will be up against a Michigan passing game that averages 262.5 yards per game (30th in the nation).

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Michigan at Indiana: Odds, prediction, betting lines and picks

Prediction

Michigan 31, Indiana 24

Money line (ML)

Indiana is a bit banged up with its offensive line depth, and the Hoosiers play a bit behind schedule too much as it is. Lack of a running game and an inefficient passing game will spell trouble against a talent-laden (albeit so far underperforming) Michigan front seven. THIS TAG IS WORTH A WATCH: a price in the low-140s would be a reasonable trigger.

Against the spread (ATS)

Tom Allen’s IU teams are 1-5 over their last half-dozen games as a home dog. Indiana benefited 100 yards in Penn State penalties in a 36-35 win against the Nittany Lions; the Hoosiers were outgained, 488 yards to 211, in that contest. IU was then partially propped up by a plus-3 in turnovers (and two touchdown drives under 30 yards) against Rutgers.

Michigan has been undone by 17 penalties in two games. The Wolverines exercised a talent advantage in outscoring the Hoosiers, 18-0, in the second half of last year’s 39-14 win in Bloomington, Indiana.

LOOK FOR MICHIGAN TO COVER in a bounce-back game Saturday in Bloomington.

Over/Under (O/U)

IU has some talent in its passing game, and Michigan’s pass defense has been spotty. On what looks to be a good weather day, the play is toward an Over, but PASS unless you can get a figure in the vicinity of 52 points.

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