Best NFL underdog picks and predictions for Week 15

Analyzing NFL Week 15 betting odds and lines, with expert predictions and picks of the 3 best underdogs to cash in on.

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Week 15 kicks off with the LA Rams as road underdogs against the San Francisco 49ers on Thursday night. Last week, 7 underdogs covered the spread in their games, while only 3 pulled off the outright upset.

Our 3 best underdog picks went 2-1 last week, as the New York Jets covered the 6.5-spread in a 32-26 overtime loss to the Miami Dolphins and the Carolina Panthers covered the 14-point spread in a 22-16 loss to the Philadelphia Eagles. But the Chicago Bears did not cover the 4-point spread as underdogs against the 49ers, as they were blown out 38-13.

On the season, we are 22-19-1 on our underdog picks of the week.

Time for some more! Below, we analyze BetMGM Sportsbook’s NFL odds, and tab the best NFL Week 15 underdog bets to cash in on among SportsbookWire’s NFL expert picks and predictions.

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NFL underdog predictions: Week 15

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Thursday at 1:18 p.m. ET. All games Sunday and ET unless noted.

RAMS (+125) at 49ers – Thursday 8:15 p.m. (Amazon Primer Video)

The 49ers will not have LT Trent Williams and likely will be on their fourth-string running back as Christian McCaffrey and Jordan Mason are on injured reserve and rookie RB Isaac Guerendo is questionable with a sprained foot on a short week. DE Nick Bosa might return, but no Williams means pass rushers Braden Fiske and Byron Young will be able to harass 49ers QB Brock Purdy. 

The Rams are 5-2 in their last 7 games and have beaten the 49ers in their last 2 meetings. Their last 5 covers have been outright wins.

The 49ers have lost their last 3 games against teams with winning records.

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Ravens at GIANTS +16 (-110) – 1 p.m. (CBS)

The Ravens have only 2 wins of more than 16 points. Both games were against teams expected to make the playoffs. They are 6-6-1 ATS this season. They are 1-3 ATS in their last 4 games.

The Giants covered the 5.5-point spread in a 3-point loss to the New Orleans Saints last week, snapping a 7-game ATS losing streak. However, only 3 of their losses have been by more than 16 points.

Sixteen points is just a huge spread.

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DOLPHINS +3 (-110) at Texans – 1 p.m. (CBS)

The Texans have just 1 win by more than 3 points in their last 7 games. Housotn has averaged 23.6 points per game over those 7 games.

The Dolphins have won 4 of their last 5 games and have averaged 27.7 points per game since the return of QB Tua Tagovailoa. 

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Want to win your survivor pool? Who to take in Week 12

Breaking down the best strategies of how to win your NFL survivor pool as the season continues into Week 12.

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Happy Thanksgiving Week.

The fun begins with 3 Thursday games, continues into Sunday with 12 games and wraps up with the Pittsburgh Steelers visiting the Indianapolis Colts Monday night.

No one is on a bye, so there’s a full slate of games to choose from for those of you still alive in NFL survivor pools.

Here are some teams to get you through to next week.

Check out: SportsbookWire’s latest NFL picks and predictions

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

– All games Sunday and ET unless noted

The chalk: Buffalo Bills

Who they play: At Detroit Lions, Thursday 12:30 p.m. (CBS)

I’m not a fan of using a team playing Thanksgiving Day, but the Bills come into this game after beating the Cleveland Browns 31-23 last week in this same stadium.

Buffalo was supposed to host Cleveland in Week 11, but the game was moved to Ford Field due to the snowstorm that dumped on Western New York.

QB Josh Allen (197 passing yards, 1 TD, 0 INT) avoided the interception bug in the win. He had 6 in his previous 3 games, including 2 in the Bills’ Week 10 overtime home loss to the Minnesota Vikings 33-30.

The Bills need to win Thursday to remain on pace with the Miami Dolphins in the AFC East — they’re both 7-3 — and to keep their hopes alive in the race for conference’s No. 1 seed. The Kansas City Chiefs are 8-2, while the Baltimore Ravens and Tennessee Titans are both 7-3.

Detroit looked good in a 31-18 road victory at the New York Giants last week. Well, RB Jamaal Williams looked good with his 3 rushing TDs. The rest of the team still needs help and the defense, which held up against the Giants, have another tough test this week.

The Lions were able to contain Giants RB Saquon Barkley, holding him to 22 rushing yards on 15 carries and 13 receiving yards on 2 catches. Now Detroit will have to deal with Buffalo’s RB duo of Devin Singletary and James Cook, while Allen is a huge running threat, too.

With Allen and WR Stefon Diggs leading the way, the Buffalo offense will put up points on a fast track in Detroit. BUFFALO is my FAVORITE SURVIVOR PLAY for Week 12.

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Off the board: Miami Dolphins

Who they play: Home vs. Houston Texans, 1 p.m. (CBS)

Miami has been one of the surprise teams this season. QB Tua Tagovailoa and WR Tyreek Hill have found a connection. This has only amplified the effect WR Jaylen Waddle has had opposite Hill. Following his rookie season with 104 catches for 1,015 yards and 6 TDs, Waddle has fit into the WR 2 role perfectly behind Hill.

Miami is coming off its bye week to take on the Texans, the team with the worst record in the NFL at 1-8-1. Coach Lovie Smith has been noncommittal on QB Davis Mills keeping the starting job. If Mills struggles vs. the Dolphins, there could be a quick change to backup QB Kyle Allen, who started 17 games for the Carolina Panthers between 2018-20.

Whether Mills remains the starter or the Texans turn to Allen, the Dolphins should not have any trouble shutting down the Houston offense, which has averaged just 13.3 points per game over the last 4 games.

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Others to consider

Kansas City Chiefs vs. Los Angeles Rams, 4:25 p.m.

Los Angeles Chargers at Arizona Cardinals, 4:05 p.m.

More NFL Week 12 picks and predictions

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