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The Louisville Cardinals (5-3, 3-2 ACC) travel to face the No. 8 Clemson Tigers (6-1, 5-0) Saturday. Kickoff from Memorial Stadium is scheduled for 7:30 p.m. ET (ESPN). Let’s analyze BetMGM Sportsbook’s college football odds around the Louisville vs. Clemson odds, and make our expert college football picks and predictions.
Louisville escaped with a 31-27 win over Boston College Friday while failing to cover as a 7-point favorite. The Cardinals put up 21 unanswered points to close out the comeback despite losing the turnover battle 3 to 0.
Clemson, which is No. 8 in the US LBM Coaches Poll, enters after being off last week. Before the bye, the Tigers beat the Virginia Cavaliers 48-31 Oct. 19 while failing to cover as 20.5-point favorites. The Tigers have put up 40+ points in 5 of their last 6 games while going 6-0 straight up.
– US LBM Coaches Poll: Conducted by the American Football Coaches Association and USA TODAY Sports
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Louisville at Clemson odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated at 10:05 a.m. ET.
- Moneyline (ML): Louisville +310 (bet $100 to win $310) | Clemson -400 (bet $400 to win $100)
- Against the spread (ATS): Louisville +10.5 (-110) | Clemson -10.5 (-110)
- Over/Under (O/U): 62.5 (O: -105 | U: -115)
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Louisville at Clemson picks and predictions
Prediction
Clemson 35, Louisville 30
Moneyline
PASS.
Clemson will pick up the win as a -400 favorite, but the Tigers are too expensive for me to advise backing them. Bet the spread and/or O/U instead.
Against the spread
LEAN LOUISVILLE +10.5 (-110).
Louisville has kept things close with ranked opponents like Miami and Notre Dame, and it has not lost by 10 or more points in any game this season.
Clemson is a good team, but this is also a team that has not faced competition since being blown out by Georgia in Week 1, so look for Louisville to give the Tigers a fight here.
This is a lean because Louisville has dropped 5 straight games ATS.
Over/Under
LEAN OVER 62.5 (-105).
The Over hit in Clemson’s last game and has cashed in 2 straight for Louisville.
These are some of the best offenses in the ACC, both averaging at least 460 yards per game and 36 points.
This is a lean because an Over number of 62.5 is very high and always comes with risk.
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