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The San Francisco 49ers (1-1) welcome the Los Angeles Chargers (1-1) to Levi’s Stadium Friday. Kickoff is set for 10 p.m. ET (NFL Network). Below, we analyze BetMGM Sportsbook’s lines around the Chargers vs. 49ers odds, and make our expert NFL picks and predictions.
The Chargers beat the Los Angeles Rams 34-17 in Week 1 of the preseason with QB Easton Stick passing for 109 yards and a TD. In the Chargers 22-17 loss to the New Orleans Saints in Week 2, Stick had 233 yards and 2 INTs. Expect star QB Justin Herbert to make his preseason debut against the 49ers. Los Angeles’ top two wide receivers, Mike Williams and Keenan Allen have also yet to play this preseason.
The 49ers lost the Las Vegas Raiders 34-7 in Week 1 as QB Trey Lance went 10-for-15 for 112 passing yards and a TD. In Week 2, the 49ers beat the Denver Broncos 21-20 and Lance went 12-for-18 for 173 yards, a TD and INT. QB Sam Darnold also played and was 11-for-14 for 109 yards, a TD and and INT. Expected starter QB Brock Purdy went 4-of-5 for 65 yards. All 3 QBs should see time on Friday.
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Chargers at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday 10:52 a.m. ET,
- Moneyline (ML): Chargers +260 (bet $100 to win $260) | 49ers -350 (bet $350 to win $100)
- Against the spread (ATS): Chargers +7.5 (-110) | 49ers -7.5 (-110)
- Over/Under (O/U): 37.5 (O: -110 | U: -110)
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Chargers at 49ers picks and predictions
Prediction
49ers 24, Chargers 17
Moneyline
PASS.
The 49ers have more starter-quality QBs and should be able to win this game; nonetheless, the home side is not worth backing at (-350). The value isn’t there.
Similarly, Stick has performed well for the Chargers and should be able to keep this game competitive. With Herbert potentially making his debut, the Chargers may get a boost from their star as well. Still, they aren’t worth taking at (+260).
Against the spread
LEAN CHARGERS +7.5 (-110).
The Chargers took down the Rams 34-17 then lost 22-17. They are averaging 25.5 points per game, and while Stick hasn’t performed the best as a passer, he did have 2 TDs on the ground in their Week 2 loss. The Chargers 1st-round pick, WR Quentin Johnston, has also been involved and should see another healthy dose of snaps.
The 49ers were destroyed by the Raiders and then beat the Broncos at home by a point. They haven’t been overly impressive despite playing several former starters. I wouldn’t expect them to blow out Los Angeles.
Take CHARGERS +7.5 (-110).
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Over/Under
BET OVER 37.5 (-110).
Both teams have topped this total in every preseason game. The Chargers average 25.5 points per game and have allowed 19.5 per game. San Fran is averaging 14 per game but allowing 27 per game.
Stick has been able to produce consistent offense and will likely get the majority of snaps. He has big-play possibilities but is also turnover prone which could get the 49ers score more often.
With Purdy looking good and likely to play several series along with the competent Darnold behind him, expect San Fran to do its part to help the Over. Back OVER 37.5 (-110).
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