The Week 16 schedule wraps up Monday night with the Los Angeles Chargers (8-6) visiting the Indianapolis Colts (4-9-1). Kickoff is 8:15 p.m. ET at Lucas Oil Stadium (ESPN). Below, we look at Chargers vs. Colts odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The Chargers beat the Tennessee Titans at home 17-14 Sunday. The game ended as a push, as the Chargers were 3-point favorites. They have won 2 games in a row and 3 of their last 4.
The Colts lost 39-36 in overtime on the road to the Minnesota Vikings, covering the 3.5-point spread. However, they blew a 33-0 lead, allowing the biggest comeback in NFL history. They have lost 4 straight games and 7 of their last 8.
Also see: All Week 16 odds and lines
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Chargers at Colts odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:50 a.m. ET.
- Moneyline (ML): Chargers -170 (bet $170 to win $100) | Colts +135 (bet $100 to win $135)
- Against the spread (ATS): Chargers -3 (-117) | Colts +3 (-103)
- Over/Under (O/U): 47.5 (O: -110 | U: -110)
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2022 betting stats
- ML: Chargers 8-6 | Colts 4-9-1
- ATS: Chargers 8-5-1 | Colts 6-8
- O/U: Chargers 5-8-1 | Colts 5-9
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Chargers vs. Colts head-to-head
Dating back to 1970, the Chargers and Colts have faced one another 30 times, with the Chargers leading the all-time series 19-11.
The Chargers won the last matchup 30-24 in overtime in 2019 and have won 4 of the last 5 meetings.
This will be Chargers QB Justin Herbert’s 1st career start against the Colts.
Colts QB Matt Ryan is 2-2 in 4 career starts against the Chargers, all as a member of the Atlanta Falcons. He has 7 TD passes and 5 INTs in the 4 meetings, and he was sacked 7 times.
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