Cardinals-49ers odds: San Francisco big favorites after 1st loss of season

Previewing Sunday’s Arizona Cardinals at San Francisco 49ers Week 11 matchup, with NFL betting odds, picks and best bets

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The Arizona Cardinals (3-6-1) are on the road to face the San Francisco 49ers (8-1) for the second time in three weeks in this NFC west battle. The game kicks off at 4:05 p.m. ET at Levi’s Stadium in Santa Clara, Calif. The game will air on FOX.

We analyze the Cardinals-49ers odds and sports betting lines, while providing betting tips and advice on this Week 11 NFL matchup.

Cardinals at 49ers: Week 11 preview, betting trends and notes

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The 49ers lost for the first time in this season in Week 10, a 27-24 overtime loss at home to the Seattle Seahawks.
Cardinals RB Kenyan Drake rushed for 110 yards and a touchdown and had 162 total yards against the 49ers two weeks ago.
Cardinals QB Kyler Murray had three touchdown passes last week and was intercepted for the first time in over a month. He set an NFL rookie record with 211 consecutive passes without an interception.
49ers QB Jimmy Garoppolo threw four touchdown passes and had 317 passing yards against the Cardinals in Week 9.
The Cardinals have scored at least 25 points in five of the last six games. The 49ers have only given up more than 25 points twice all season.

Cardinals at 49ers: Key injuries

Cardinals: DE’s Jonathan Bullard (foot) and Rodney Gunter (calf), LB Terrell Suggs (hamstring) and CB Patrick Peterson (calf) are questionable. RB Chase Edmonds (hamstring) is out.

49ers: WR Dante Pettis (back) and LB Azeez Al-Shaair (concussion) are questionable. WR Emmanuel Sanders (ribs) and TE George Kittle (knee) are doubtful. OT Joe Staley (finger), RB Matt Breida (ankle) and DT D.J. Jones (groin) are out.

Cardinals at 49ers: Odds, betting lines and prediction

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:50 p.m. ET.

Prediction

49ers 28, Cardinals 27

Moneyline (?)

AVOID. At -500, the San Francisco 49ers are almost a sure thing, but it will win you almost nothing. A $10 bet will only earn a $2 profit. However, the Cardinals at +370 make one heck of a value, but considering the imbalanced matchup, it isn’t worth the wager.

Against the Spread (?)

The 49ers are favored by 11.5 (+100) points at home. They are 5-4 ATS this season, while the Cardinals have been an impressive 7-3 ATS. The Cardinals are bad defensively, but the 49ers are missing enough weapons on offense to keep from pulling ahead by a bunch. The Cardinals offense is scoring enough to keep them in the game. Take the CARDINALS at +11.5 (-121).

Over/Under (?)

The total is set at 45.5, which seems low. While the 49ers are allowing only 14.3 points per game, good for second in the league, the Cardinals have scored at least 25 in five of the last six games, including against the 49ers two weeks ago. The Cardinals allow 28.1 points per game. Games involving the Cardinals have hit the Over in six of 10 games. Take the OVER (+100) in this one.

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Is Kenyan Drake taking over for Cardinals?

Less than two weeks after being traded from Miami to Arizona, Kenyan Drake is already making waves. Trade: Arizona has reached agreement in principle to trade a conditional 2020 draft pick to Miami for RB Kenyan Drake, league sources tell ESPN. – …

Less than two weeks after being traded from Miami to Arizona, Kenyan Drake is already making waves.

Trade: Arizona has reached agreement in principle to trade a conditional 2020 draft pick to Miami for RB Kenyan Drake, league sources tell ESPN.

— Adam Schefter (@AdamSchefter) October 28, 2019

In his first week with the Cardinals, Drake took 15 carries for 110 yards and a lone touchdown. An impressive first outing with his new team.

His Arizona debut came at the right time for him, as David Johnson, their solid back for the last few seasons was inactive.

Johnson has been battling injuries, he spent all of 2018 on the sidelines after sustaining a knee injury.

Drake’s second week with the team was a true test, Johnson was back on the field, so it was a true test to see where he would fit into the mix with the incumbent starter.

In the Cardinals’ contest against the Buccaneers, Drake took over as the lead back.

The Alabama product had 10 carries to Johnson five, along with 35 yards to Johnson’s two.

Cardinals head coach Kliff Kingsbury weighed in on Drake’s success with the team.

“We just felt like with Drake, needed to get something going and kept him rolling,” Kingsbury said. “The last couple weeks, practice, games [he] has brought a little pop to the run game, the pass game, and we felt like he was the guy to try and close the game out with.”

There’s still a relatively small sample size when it comes to what he’s capable of with Arizona, but with plenty of time left in the regular season, he will have the ability to show the Dolphins front office what they are missing out on.

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Studs and duds in Cardinals’ 30-27 loss to Bucs

Christian Kirk had a huge game. David Johnson struggled in his return.

The Arizona Cardinals had some solid performances from players on Sunday when they lost to the Tampa Bay Buccaneers 30-27. Some players did not perform as well.

Who were the studs and duds in the game?

Stud: WR Christian Kirk

Kirk was huge. He had six receptions for 138 yards and three touchdowns. It was the first time a player had three receiving touchdowns since Larry Fitzgerald did it in 2015. He had not had a touchdown all season. He doubled his career touchdown total. Based on his production in his seven games played so far this season, he is on pace for 75 catches and 867 yards. Not bad for a 13-game season.

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