If you want a real difference between Notre Dame and USF, look at their respective running games. Kyren Williams had his coming-out party against Duke, rushing for 112 yards and two touchdowns in his first start for the Irish. He also caught a pass from Ian Book and gained 75 yards, so he also led the Irish in receiving yards. It’s clear who the main guy is in Notre Dame’s backfield.
After its season-opening win over The Citadel, USF has Kelley Joiner as its leading rusher. Despite an impressive number of yards a carry and a touchdown, he was caught in the middle between Johnny Ford and Noah Johnson as far as carries. So the Bulls relied on a balanced rushing attack between three players. Against a team like the Irish, that could mean fresh bodies the entire way.
Remember that USF is coming off a game in which it ran more than it passed. Hey, if you have more than one guy who can do the job, feel free to use them all. The question is whether all three of them can outproduce Williams or if Williams can prove that quality trumps quantity.