First look: Jacksonville Jaguars at Indianapolis Colts odds and lines

Looking at Sunday’s Jacksonville Jaguars at Indianapolis Colts Week 1 NFL odds, lines and trends. Here’s what you need to know.

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The Indianapolis Colts welcome the Jacksonville Jaguars to Lucas Oil Stadium Sunday in Week 1 NFL action. Kickoff between these AFC South rivals is set for 1 p.m. ET (FOX). Below, we look at Jaguars vs. Colts odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The Jaguars look to build upon their 2022 playoff appearance, the franchise’s first postseason action since the 2017 season. The fanbase will have high expectations that QB Trevor Lawrence can get them back to consistently being in the postseason. Jacksonville finished 9-8 last season in head coach Doug Pederson’s first season with the organization and is a -155 favorite to capture the AFC South for a 2nd straight year.

The Colts drafted QB Anthony Richardson with the 4th-overall selection this offseason, but all eyes have been on the situation with RB Jonathan Taylor. The stud running back was involved in an offseason contract dispute and has been placed on the PUP to begin the season, missing at least 4 games before he’s able to return to action.

Richardson, from the University of Florida, has high expectations entering his rookie season, but the Colts as a franchise do not. RB Zack Moss — a prime candidate to see the bulk of the work with Taylor sidelined — has yet to return to practice following a broken arm in the summer which may leave work to RBs Deon Jackson and Evan Hull.  WR Michael Pittman Jr. returns the team’s main offensive weapon in the passing game.

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Jaguars vs. Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 10:23 p.m. ET,

  • Moneyline (ML): Jaguars -225 (bet $225 to win $100) | Colts +180  (bet $100 to win $180)
  • Against the spread (ATS): Jaguars -4.5 (-110) | Colts +4.5 (-110)
  • Over/Under (O/U): 45 (O: -110 | U: -110)

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2022 betting stats

  • ML: Jaguars 10-9 | Colts 4-12-1
  • ATS: Jaguars 10-9 | Colts 6-11
  • O/U: Jaguars 9-10 | Colts 7-10

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Jaguars vs. Colts head-to-head

The Colts and Jaguars have a lengthy head-to-head history. Indianapolis leads the series 27-17; however, the Jaguars have won 9 of the last 15 meetings.

The two teams’ last matchup was in Week 6 last year, a 34-27 Colts victory. Former Colts QB Matt Ryan threw for 3 touchdowns and 389 yards as Indianapolis covered as a 1-point favorite while the Over (41.5) cashed.

The Jaguars haven’t gone to Indianapolis and come out with a win since 2017, so despite being favorites, Jacksonville has historically struggled at Lucas Oil Stadium.

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First look: Jacksonville Jaguars at Indianapolis Colts odds and lines

Looking at Sunday’s Jacksonville Jaguars at Indianapolis Colts Week 6 NFL odds, lines and trends. Here’s what you need to know.

The Jacksonville Jaguars (2-3) travel to take on the Indianapolis Colts (2-2-1) Sunday in Week 6. Kickoff from Lucas Oil Stadium 1 p.m. ET (CBS). Below, we look at Jaguars vs. Colts odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Jaguars got off to a 2-1 start to the season before losing their last 2 games to the Philadelphia Eagles (29-21) and the Houston Texans (13-6). QB Trevor Lawrence has turned the ball over a combined 7 times in the last 2 weeks and will look to do a better job protecting the ball Sunday.

The Colts were able to squeak out a narrow 12-9 victory in Week 5 against the Denver Broncos in a game where both offenses were unable to get much going. Indianapolis will also need QB Matt Ryan to protect the football as he’s thrown 7 interceptions and fumbled the ball 11 times (3 lost).

Also seeAll Week 6 odds and lines

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Jaguars at Colts odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 8:50 a.m. ET.

  • Moneyline (ML): Jaguars +105 (bet $100 to win $105) | Colts -125 (bet $125 to win $100)
  • Against the spread (ATS): Jaguars +2.5 (-112) | Colts -2.5 (-108)
  • Over/Under (O/U): 41.5 (O: -105 | U: -115)

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2022 betting stats

  • ML: Jaguars 2-3 | Colts 2-2-1
  • ATS: Jaguars 2-3 | Colts 2-3
  • O/U: Jaguars 3-2 | Colts 0-5

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Jaguars vs. Colts head-to-head

This Sunday’s showdown will be the 44th meeting between the Jaguars and the Colts. Indianapolis has a 26-17 edge in the all-time matchup.

The Jaguars have had more success recently, though, winning 4 of the last 6 games in the series. Jacksonville has won 2 straight against Indianapolis and shut out the Colts 24-0 at home in Week 2.

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If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

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