First look: Jacksonville Jaguars at Indianapolis Colts odds and lines

Looking at Sunday’s Jacksonville Jaguars at Indianapolis Colts Week 1 NFL odds, lines and trends. Here’s what you need to know.

[gambcom-standard rankid=”3011″ ]

The Indianapolis Colts welcome the Jacksonville Jaguars to Lucas Oil Stadium Sunday in Week 1 NFL action. Kickoff between these AFC South rivals is set for 1 p.m. ET (FOX). Below, we look at Jaguars vs. Colts odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The Jaguars look to build upon their 2022 playoff appearance, the franchise’s first postseason action since the 2017 season. The fanbase will have high expectations that QB Trevor Lawrence can get them back to consistently being in the postseason. Jacksonville finished 9-8 last season in head coach Doug Pederson’s first season with the organization and is a -155 favorite to capture the AFC South for a 2nd straight year.

The Colts drafted QB Anthony Richardson with the 4th-overall selection this offseason, but all eyes have been on the situation with RB Jonathan Taylor. The stud running back was involved in an offseason contract dispute and has been placed on the PUP to begin the season, missing at least 4 games before he’s able to return to action.

Richardson, from the University of Florida, has high expectations entering his rookie season, but the Colts as a franchise do not. RB Zack Moss — a prime candidate to see the bulk of the work with Taylor sidelined — has yet to return to practice following a broken arm in the summer which may leave work to RBs Deon Jackson and Evan Hull.  WR Michael Pittman Jr. returns the team’s main offensive weapon in the passing game.

Play to win $10K: USA TODAY NFL Survivor pool!

Jaguars vs. Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 10:23 p.m. ET,

  • Moneyline (ML): Jaguars -225 (bet $225 to win $100) | Colts +180  (bet $100 to win $180)
  • Against the spread (ATS): Jaguars -4.5 (-110) | Colts +4.5 (-110)
  • Over/Under (O/U): 45 (O: -110 | U: -110)

WIN YOUR FANTASY FOOTBALL LEAGUE!
The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Save 25% off the Internet’s best-kept secret. Subscribe now!

[gambcom-standard rankid=”3012″ ]

2022 betting stats

  • ML: Jaguars 10-9 | Colts 4-12-1
  • ATS: Jaguars 10-9 | Colts 6-11
  • O/U: Jaguars 9-10 | Colts 7-10

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

Jaguars vs. Colts head-to-head

The Colts and Jaguars have a lengthy head-to-head history. Indianapolis leads the series 27-17; however, the Jaguars have won 9 of the last 15 meetings.

The two teams’ last matchup was in Week 6 last year, a 34-27 Colts victory. Former Colts QB Matt Ryan threw for 3 touchdowns and 389 yards as Indianapolis covered as a 1-point favorite while the Over (41.5) cashed.

The Jaguars haven’t gone to Indianapolis and come out with a win since 2017, so despite being favorites, Jacksonville has historically struggled at Lucas Oil Stadium.

Play our free daily Pick’em Challenge and win! Play now!

[gambcom-standard rankid=”5″ ]

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @nathanbeighle_ on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]