First look: Jacksonville Jaguars vs. Buffalo Bills odds and lines

Looking at Sunday’s Jacksonville Jaguars vs. Buffalo Bills Week 5 NFL odds, lines and trends. Here’s what you need to know.

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The Jacksonville Jaguars (2-2) faceoff against the Buffalo Bills (3-1) on Sunday in London. Kickoff from Tottenham Hotspur Stadium is set for 9:30 a.m. ET (NFL Network). Below, we look at Jaguars vs. Bills odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

Jacksonville enters off a 23-7 victory over the Atlanta Falcons in London in Week 4, covering as a 3.5-point favorite. QB Trevor Lawrence went 23 of 30 passing for 207 yards and a touchdown with his top target being WR Christian Kirk who had 8 receptions off 12 targets for 84 yards. WR Calvin Ridley scored the TD but had just 2 receptions for 38 yards. The Jags might have an advantage on Sunday, having already been in London for a week.

The Bills took down the Miami Dolphins 48-20 Sunday, covering as 3-point favorites and continuing their offensive dominance. Buffalo has scored at least 37 points in its last 3 games. QB Josh Allen led the way going 21 of 25 passing for 320 yards and 4 TDs while also adding a score on the ground. WR Stefon Diggs had 6 receptions for 120 yards and 3 TDs.

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Jaguars vs. Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:17 a.m. ET.

  • Moneyline (ML): Jaguars +200 (bet $100 to win $200) | Bills -250 (bet $250 to win $100)
  • Against the spread (ATS): Jaguars +5.5 (-110) | Bills -5.5 (-110)
  • Over/Under (O/U): 48 (O: -110 | U: -110)

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2023 betting stats

  • ML: Jaguars 2-2 | Bills 3-1
  • ATS: Jaguars 2-2 | Bills 3-1
  • O/U: Jaguars 2-2 | Bills 2-2

Jaguars vs. Bills head-to-head

The last time these teams faced off was a 9-6 Jacksonville victory as 14.5-point underdogs in Nov. 2021. The Bills are 4-3 both straight up and against the spread (ATS) in the last 7 matchups dating back to 2012 with the Over cashing in 5 of those games.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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