Indiana at Ohio State odds, picks and predictions

Analyzing Saturday’s Indiana at Ohio State odds and lines, with college football expert picks, predictions and best bets.

The Indiana Hoosiers (3-6, 1-5 Big Ten) meet the No. 2 Ohio State Buckeyes (9-0, 6-0) Saturday at Ohio Stadium. Kickoff is scheduled for noon ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Indiana vs. Ohio State odds, and make our expert college football picks and predictions.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

The Hoosiers are tied for last in the East Division with just 1 conference victory in 6 tries. Since topping Illinois in the regular-season opener Sept. 2, Indiana has dropped 6 straight Big Ten games by 5 or more points, with 4 of the setbacks coming by 14 or more points.

The Buckeyes won just 21-7 in a road trip to Northwestern, struggling with gusty winds to gale force in Evanston and failing to cover a 37.5-point spread. That ended a 7-game streak with at least 44 points, but the 7 points allowed was also a season-best.

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Indiana at Ohio State odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 7 a.m. ET.

  • Moneyline (ML): Off the board (OTB)
  • Against the spread: Indiana +40.5 (-112) | Ohio State -40.5 (-108)
  • Over/Under (O/U): 57.5 (O: -117 | U: -103)

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Indiana at Ohio State picks and predictions

Prediction

Ohio State 55, Indiana 14

Moneyline

There was no money line at the time of publishing, but it wouldn’t be worth pursuing even if one is released before kickoff.

Against the spread

OHIO STATE -40.5 (-108) is the slight lean here, but play this very lightly.

If we learned anything last week, it’s that the fall weather is just as much a factor as the offenses and defenses playing the game.

The temperature will be around 40 degrees with winds anywhere from 9-12 mph, but it won’t be nearly as blustery as last weekend at Northwestern. The high-octane pass game for Ohio State should be effective yet again with more favorable conditions.

Over/Under

OVER 57.5 (-117) is the best play on the board.

Ohio State is certain to be angry after last week’s struggles against a 1-win Northwestern side. While the weather certainly was to blame, the Buckeyes made national headlines due to the poor performance, although ultimately Ohio State won, and it didn’t affect its standing in the College Football Playoff rankings.

Still, it wouldn’t be surprising to see Ohio State take care of the Over all on its own here.

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Want action on this game or any other NCAA football matchup? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

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First look: Indiana at Ohio State odds and lines

Looking at Saturday’s Indiana at Ohio State college football odds, lines and trends. Here’s what you need to know.

The Indiana Hoosiers (3-6, 1-5 Big Ten) and No. 2 Ohio State Buckeyes (9-0, 6-0) meet Saturday at Ohio Stadium in Columbus. Kickoff is scheduled for noon ET (FOX). Below, we look at Indiana vs. Ohio State odds from Tipico Sportsbook; check back for all our college football picks and predictions.

The Hoosiers took it on the chin against Penn State at home, falling 45-14 at “The Rock” in Bloomington. After a 3-0 SU start, IU has now dropped its past 6 games, and bowl eligibility will not be possible unless it wins out.

The Buckeyes traveled to Northwestern last week and really struggled with winds blowing anywhere from 35-45 mph. The pass game was virtually non-existent, and Heisman Trophy candidate QB C.J. Stroud actually had more rushing yards than passing yards in the surprisingly narrow 21-7 win over the 1-win Wildcats.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

Stream select live college football games and full replays: Get ESPN+

Indiana at Ohio State odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:50 a.m. ET.

  • Moneyline (ML): Off the board
  • Against the spread (ATS): Indiana +41 (-112) | Ohio State -41 (-108)
  • Over/Under (O/U): 57.5 (O: -110 | U: -110)

2022 betting stats

  • ML: Indiana 3-6 | Ohio State 9-0
  • ATS: Indiana 3-6 | Ohio State 4-4-1
  • O/U: Indiana 5-4 | Ohio State 6-3

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

Indiana at Ohio State head-to-head

The Buckeyes led the all-time series 77-12-5, including each of the previous 26 meetings dating back to 1991. The Hoosiers posted a 27-27 tie in the 1990 meeting, and the last time IU won outright was 41-7 in Bloomington back on Oct. 8, 1988. It hasn’t won in Columbus since Oct. 10, 1987, and that is the only win for the Hoosiers on the road in this series since 1951.

Play our free daily Pick’em Challenge and win! Play now!

Want action on this game or any other NCAA football matchup? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

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