Syracuse at Houston NCAA Tournament Sweet 16 Odds, Picks and Prediction

A Sweet 16 battle features the No. 2 seed Houston Cougars (24-3) playing as 6.5-point favorites against the No. 11 seed Syracuse Orange (16-9) on Saturday

A Sweet 16 battle features the No. 2 seed Houston Cougars (24-3) playing as 6.5-point favorites against the No. 11 seed Syracuse Orange (16-9) on Saturday at Hinkle Fieldhouse. The NCAA Tournament contest tips off at 9:55 PM ET, with the winner moving on to the Midwest Region bracket final.

The Cougars were led by 22 points from Quentin Grimes in a 63-60 win over Rutgers on Sunday. They failed to cover the spread in the contest and the teams combined to go under the 131.5-point over/under.

Buddy Boeheim led the way for the Orange with a team-high 25 points last time out as they picked up a 75-72 win over West Virginia and covered the 4-point spread as underdogs. The teams combined to go under the 148 point total set for the matchup.

Syracuse at Houston: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list.
Lines last updated at 8:30 PM ET on March 27, 2021.

  • Money line: Syracuse +220 (bet $100 to win $220) | Houston -275 (bet $275 to win $100)
  • Against the spread/ATS: Syracuse +6.5 (-110) | Houston -6.5 (-110)
  • Over/Under: 141 (O: -110 | U: -110)

Houston: Three things to know

  • The Cougars scoring leader is Grimes, who averages 18.1 points per game. Grimes is the top three-point shooter for the team, connecting on 3.4 per game.
  • The Cougars record 77.4 points per game, seven more points than the 70.4 the Orange allow.
  • Houston has a 15-0 record against the spread and an 18-1 record overall when putting up more than 70.4 points.

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Syracuse: Three things to know

  • The Orange scoring leader is Boeheim, who averages 18.1 points per game. Boeheim is the top three-point shooter for the team, knocking down 3.2 per game.
  • The Orange’s 75.9 points per game are 18.0 more points than the 57.9 the Cougars allow to opponents.
  • When it scores more than 57.9 points, Syracuse is 13-0 against the spread and 18-9 overall.

Syracuse at Houston: Odds, betting lines, predictions and picks

Prediction

Houston 75, Syracuse 65

Money line

The Houston Cougars are the favorites to win this game by both the model and BetMGM.

Against the spread (ATS)

The Cougars are the bet in this game. They’re favored by 3 more points in the model than MGM (9.5 to 6.5).

Over/Under (O/U)

MGM and the model are extremely close in their point total projections for this contest, within 0.9 points of each other.

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March Madness: Houston vs. Syracuse odds, picks and prediction

Previewing Saturday’s Houston Cougars vs. Syracuse Orange odds and lines, with March Madness Sweet 16 picks and predictions.

The Houston Cougars (26-3) take on the Syracuse Orange (18-9) in a Midwest Region Sweet 16 game Saturday night. The second-seeded Cougars and 11th-seeded Orange will tip-off at 9:55 p.m. ET at Hinkle Fieldhouse in Indianapolis. Below, we analyze the Houston-Syracuse odds and lines, with March Madness NCAA Tournament picks and predictions.

With their offense leading the way, the Cougars reeled off seven straight wins before heading to Indiana. After wins over Cleveland State and Rutgers — the latter via a monster comeback late in the game — the Cougar win streak now stands at nine.

Over those nine straight wins, Houston has been improved in taking care of the basketball with just 8.2 turnovers per contest and in launching it from beyond the 3-point arc (37.8% accuracy).

A peaking-at-the-right-time Syracuse five is 5-1 over its last six games and 8-3 over its last 11. G Buddy Boeheim has had the hot hand in that Orange surge. Boeheim — who has scored 55 points in the tournament — has averaged 24.2 points over his last nine games. Over its two tourney wins, the Orange outshot their foes (San Diego State and West Virginia), 53.5% to 36.5%.

Houston vs. Syracuse: Odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at noon ET.

  • Money line: Houston -275 (bet $275 to win $100) | Syracuse +220 (bet $100 to win $220)
  • Against the spread/ATS: Houston -6 (-110) | Syracuse +6 (-110)
  • Over/Under: 140 (O: -110 | U: -110)

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Houston vs. Syracuse: Odds, lines, predictions and picks

Prediction

Houston 74, Syracuse 70

Money line (ML)

The Cougars are the more talented team at both ends of the floor, but the lean on the ATS play is toward Syracuse. Houston (-275) may offer a sliver of value for the straight-up win.

Consider middling the play by taking Syracuse plus the points and Houston outright if the price on the Cougars should fall a bit.

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Against the spread (ATS)

The Orange have strung together some high-level performances this month, and their offensive trend line is particularly impressive. Syracuse is 6-0 ATS in March and four of those covers have been by ATS margins of 7-plus points.

The Cougars are unaccustomed to a five-day layoff; the last time they had one was followed by an ATS disaster against Wichita State Feb. 18. Conversely, SU has put up solid shooting numbers following recent layoffs.

Syracuse has fared well lately against slow-down styles like the one played by Houston in recent ATS wins against San Diego State, Virginia and Clemson. Peg the Orange as getting this one close to one-possession territory.

BACK SYRACUSE +6 (-110).

Over/Under (O/U)

This total figures as perhaps 3 points too low. The Syracuse offense deserves enough respect to lean both teams into the 70s.

BACK THE OVER 140 (-110).

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