Sunday updates will begin when teams start releasing official pregame inactives and starter information to the league. This is typically around 60-90 minutes prior to the kickoff of their game.
Week 1 gameday inactives, weather and notes
Key game-time decisions
Early games: WR Emmanuel Sanders
Afternoon games: None
Sunday night: None
Monday night: None
Sunday early games
Philadelphia Eagles at Atlanta Falcons (1:00 p.m. EDT)
Kickoff Weather: Dome stadium
Eagles
Inactives:
Lineup notes: No noteworthy injuries for fantasy
Falcons
Inactives:
Lineup notes: No noteworthy injuries for fantasy
Pittsburgh Steelers at Buffalo Bills (1:00 p.m. EDT)
Kickoff Weather: 73 degrees, overcast
Steelers
Inactives:
Lineup notes: No noteworthy injuries for fantasy
Bills
Inactives:
Lineup notes: WR Emmanuel Sanders (foot) is questionable and was limited all week. He is likely a game-time decision.
Minnesota Vikings at Cincinnati Bengals (1:00 p.m. EDT)
Kickoff Weather: 81 degrees, partly cloudy
Vikings
Inactives:
Lineup notes: No noteworthy injuries for fantasy
Bengals
Inactives:
Lineup notes: No noteworthy injuries for fantasy
San Francisco 49ers at Detroit Lions (1:00 p.m. EDT)
Kickoff Weather: Dome stadium
49ers
Inactives:
Lineup notes: WR Brandon Aiyuk (hamstring) was a full participant all week and is not on the injury report. Backup QB Trey Lance (finger) was limited all week but didn’t receive a designation.
Lions
Inactives:
Lineup notes: TE T.J. Hockenson (shoulder) participated every day in full and is not on the injury report. Starting LT Taylor Decker (finger) was placed on Injured Reserve.
Arizona Cardinals at Tennessee Titans (1:00 p.m. EDT)
Kickoff Weather: 83 degrees, clear
Cardinals
Inactives:
Lineup notes: No noteworthy injuries for fantasy
Titans
Inactives:
Lineup notes: WR Josh Reynolds (foot) was limited Thursday and Friday, drawing a questionable tag for his Tennessee debut.
Seattle Seahawks at Indianapolis Colts (1:00 p.m. EDT)
Kickoff Weather: 81 degrees, clear (retractable-roof dome)
SEahawks
Inactives:
Lineup notes: RB Chris Carson (neck) appeared on the participation list as a full-go Friday. He is not on the injury report. WR DK Metcalf (calf) was listed as limited Friday but didn’t get an injury designation.
Colts
Inactives:
Lineup notes: QB Carson Wentz (foot) fully practiced all week and is not on the injury report. Starting LT Eric Fisher (Achilles) has been ruled out, and star OG Quenton Nelson (back, foot) is questionable but expected to play.
Los Angeles Chargers at Washington Football Team (1:00 p.m. EDT)
Kickoff Weather: 82 degrees, clear
Chargers
Inactives:
Lineup notes: RB Austin Ekeler (hamstring) didn’t go Wednesdays or Thursday but was limited Friday, drawing a questionable tag. Reports say he will see a full workload.
Football team
Inactives:
Lineup notes: WR Curtis Samuel (groin) was placed on the Reserve/Injured list and will miss at least three games.
New York Jets at Carolina Panthers (1:00 p.m. EDT)
Kickoff Weather: 82 degrees, clear
Jets
Inactives:
Lineup notes: WR Jamison Crowder (illness) will not be activated from the Reserve/COVID-19 list prior to kickoff.
Panthers
Inactives:
Lineup notes: No noteworthy injuries for fantasy
Jacksonville Jaguars at Houston Texans (1:00 p.m. EDT)
Kickoff Weather: 85 degrees, humid, mostly cloudy (retractable-roof dome)
Jaguars
Inactives:
Lineup notes: WRs DJ Chark Jr. (finger) and Marvin Jones Jr. (shoulder) both avoided the injury report and will play.
Texans
Inactives:
Lineup notes: No noteworthy injuries for fantasy
Sunday afternoon games
Cleveland Browns at Kansas City Chiefs (4:25 p.m. EDT)
Kickoff Weather: 90 degrees, clear
Browns
Inactives:
Lineup notes: WR Odell Beckham Jr. (knee) is questionable and was limited all week, likely as a precaution.
Chiefs
Inactives:
Lineup notes: WR Mecole Hardman (oblique) was a full participant Thursday and Friday after being limited Wednesday. He is not on the injury report.
Miami Dolphins at New England Patriots (4:25 p.m. EDT)
Kickoff Weather: 80 degrees, partly cloudy
Dolphins
Inactives:
Lineup notes: WR Preston Williams (foot) is questionable after being limited all week in practice.
Patriots
Inactives:
Lineup notes: WR Nelson Agholor (ankle) is questionable after going limited, out, and limited, respectively, in practice Wednesday through Friday.
Green Bay Packers at New Orleans Saints* (4:25 p.m. EDT)
*played in Jacksonville, due to Hurricane Ida
Kickoff Weather: 86 degrees, partly cloudy
Packers
Lineup notes: No noteworthy injuries for fantasy
Saints
Lineup notes: TE Adam Trautman (foot) missed a few weeks but is not on the injury report for the season-opening week. WR Tre’Quan Smith (hamstring) has been ruled out.
Denver Broncos at New York Giants (4:25 p.m. EDT)
Kickoff Weather: 85 degrees, partly cloudy
Broncos
Inactives:
Lineup notes: TE Noah Fant (knee) was a full-go Thursday and Friday week and is expected to play after avoiding the injury report.
Giants
Inactives:
Lineup notes: RB Saquon Barkley (knee) is questionable after being limited all week. The expectation is he will play but on a snap count. TE Evan Engram (calf) has been ruled out, and WR Kenny Golladay (hamstring) is not on the injury report after being limited all week.
Sunday Night Football
Chicago Bears at Los Angeles Rams (8:20 p.m. EDT)
Kickoff Weather: 74 degrees, clear (open-air dome)
Bears
Inactives:
Lineup notes: WR Darnell Mooney (back) is questionable but expected to play after fully practicing Friday.
Rams
Inactives:
Lineup notes: No noteworthy injuries for fantasy
Monday Night Football
Baltimore Ravens at Las Vegas Raiders (8:15 p.m. EDT)
Kickoff Weather: Dome stadium
Ravens
Lineup notes: RB Gus Edwards (knee) was lost for the year after suffering a torn ACL. RB Ty’Son Williams and newcomer Latavius Murray figure to share touches in a manner favoring the former.
Raiders
Lineup notes: RB Josh Jacobs (toe) was limited in practice Thursday and Friday. He could see a lighter workload Monday night, but Jacobs is not on the injury report after being limited as a precaution in Saturday’s practice.
All weather reports are courtesy of The Football Database.