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The Philadelphia Eagles (8-1) visit the Indianapolis Colts (4-5-1) Sunday at 1 p.m. ET (CBS). Below, we analyze Tipico Sportsbook’s lines around the Eagles vs. Colts odds, and make our expert NFL picks and predictions.
Coming off its first loss of the season — a 32-21 setback at Washington Monday night — Philadelphia travels to Indianapolis to battle the struggling Colts under new coach Jeff Saturday.
The Eagles, who were 11-point favorites, uncharacteristically had 4 turnovers against the Commanders. After having only 3 turnovers in its first 8 games, Philadelphia will look to return to the solid play which led them to the best start in the NFL through Week 9.
The Colts, after going away from QB Matt Ryan under coach Frank Reich, went back to the veteran last week against the Raiders and won 25-20. Ryan responded with 222 passing yards, 38 rushing yards and 2 TDs (1 passing, 1 rushing), including a career-best 39-yard TD for the Colts, who were 4.5-point road underdogs in Sin City.
They’ll look to continue their trek back into relevance at home this week. If they hope to pull off a second victory in a row, RB Jonathan Taylor will have to be a major part in the success. Against an Eagles defense which has strengthened itself in recent days against the run, it will be a difficult task.
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Eagles at Colts odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9:31 p.m. ET.
- Moneyline (ML): Eagles -290 (bet $290 to win $100) | Colts +240 (bet $100 to win $240)
- Against the spread (ATS): Eagles -6.5 (-112) | Colts +6.5 (-108)
- Over/Under (O/U): 45.5 (O: -110 | U: -110)
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Eagles at Colts key injuries
Eagles
- TE Dallas Goedert (shoulder) out — injured reserve
- CB Avonte Maddox (hamstring) out — IR
Colts
- LB Zaire Franklin (illness) questionable
- LB Shaquille Leonard (back) out — IR
- DE Kwity Paye (ankle) out
- CB Isaiah Rodgers (illness) questionable
- OL Braden Smith (back) questionable
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Eagles at Colts picks and predictions
Prediction
Eagles 31, Colts 17
Moneyline
PASS.
The Eagles (-290) will look to rebound after their 1st loss in style. This does not bode well for the Colts. However, Philly’s price is too high to wager on.
Against the spread
BET EAGLES -6.5 (-112).
The Eagles are 4-0 on the road this season. They do not turn the ball over much — with only 7 on the season — which leads to being able to play from the lead. This is especially important in a road environment.
Although the Colts played hard for coach Saturday in his debut, it was against a Raiders team full of turmoil. The Eagles are not in turmoil and they will want to win this game to stay ahead of the Giants (7-2) and Cowboys (6-3) in the NFC East Division.
Although coming off a loss, I don’t see Philadelphia allowing Indy to keep this game close. The Eagles will want to make this an emphatic victory and jump out early. This should be a double-digit win for the Eagles, which is why PHILADELPHIA -6.5 (-112) is my FAVORITE PLAY in this game.
Over/Under
BET OVER 45.5 (-110).
The Colts have played 8 of their 10 games Under this season. One of those 2 Overs came last week against the Raiders in the 25-20 victory with an O/U line of 41.5. The other Over was a 34-27 home win against the Jaguars, also with an O/U of 41.5. With Taylor getting healthy and back on track, Ryan should be able to put up points in this game for the Colts.
After only scoring 21 points in the Monday home loss to the Commanders, the Eagles will look to get their offense back on track as well. Goedert is out and on IR, but WRs DeVonta Smith and A.J. Brown will provide plenty for QB Jalen Hurts to throw to. In the run game, after 0 TDs in 2021, RB Miles Sanders has 6 this season. He could add another rushing score Sunday as both teams will score some points. Although it could be a narrow escape, I like OVER 45.5 (-110) in this one.
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