Chicago Cubs at Chicago White Sox odds, picks and predictions

Analyzing Saturday’s Chicago Cubs at Chicago White Sox odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago Cubs (58-60) and Chicago White Sox (28-90) close out a 2-game series Saturday. First pitch from Guaranteed Rate Field is scheduled for 7:15 p.m. ET (FOX).  Let’s analyze BetMGM Sportsbook’s lines around the Cubs vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 3-0

The Cubs took the Friday opener 7-6 for their 3rd straight win and the 7th in their last 9 games. They seek to complete the series sweep over their crosstown rivals.

The White Sox snapped a 21-game losing streak Tuesday, but have now lost another 2 in a row.

Cubs at White Sox projected starters

LHP Justin Steele vs. RHP Chris Flexen

Steele (3-5, 3.33 ERA) makes his 19th start. He has a 1.09 WHIP, 2.4 BB/9 and 8.7 K/9 through 108 innings.

  • Last start: Win, 6 2/3 IP, 2 ER, 4 H, 2 BB, 6 K in 6-2 home victory over St. Louis Cardinals Sunday
  • His runs allowed over his last 4 starts have been 5, 2, 5 and 2
  • Never faced White Sox before

Flexen (2-11, 5.53 ERA) makes his 23rd start and 25th appearance. He has a 1.49 WHIP, 3.6 BB/9 and 6.6 K/9 through 114 innings.

  • Last start: Loss, 1 2/3 IP, 6 ER (8 R), 7 H, 3 BB, 3 K in 13-7 road loss to Minnesota Twins Sunday
  • White Sox have lost his last 16 starts
  • 2024 vs. Cubs: 0-0, 1 road start (June 4), 5 IP, 1 ER, 3 H, 0 BB, 4 K in 7-6 defeat
  • Career vs. Cubs: 0-1, 6.23 ERA (21 2/3 IP, 15 ER), 1.89 WHIP, 6.2 K/9 in 7 appearances (4 starts)

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Cubs at White Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:24 p.m. ET.

  • Moneyline (ML): Cubs -250 (bet $250 to win $100) | White Sox +200 (bet $100 to win $200)
  • Run line (RL)/Against the spread (ATS): Cubs -2.5 (-105) | White Sox +2.5 (-115)
  • Over/Under (O/U): 9 (O: -105 | U: -115)

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Cubs at White Sox picks and predictions

Prediction

Cubs 6, White Sox 4

Moneyline

The Cubs (-250) have won 7 of their last 9 games and the last 4 meetings between these teams.

The White Sox have lost 23 of their last 24. It makes no sense to bet the White Sox on the moneyline considering their last month, and it makes no sense to bet the Cubs at -250 because there is no value.

PASS.

Run line/Against the spread

Since snapping their 21-game losing streak, the White Sox have lost two 1-run games. All 3 games between the 2 teams this season have been 7-6 wins by the Cubs.

Four of the Cubs’ last 6 wins overall have been by 3 or more runs.

While 9 of the final 10 losses during the White Sox’s 21-game skid were by at least 3 runs, I expect this game to stay closer, like the other 3 meetings this season.

BET WHITE SOX +2.5 (-115).

Over/Under

All 3 previous matchups this season have had 13 total runs.

The Cubs have scored 5 or more runs in 7 of their last 9 games.

The White Sox have scored 5 or more in 3 of their last 5.

Each of Flexen’s last 3 starts have ended with 12 or more total runs scored.

BET OVER 9 (-105).

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Chicago White Sox at Chicago Cubs odds, picks and predictions

Analyzing Tuesday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

The Chicago White Sox (47-72) and Chicago Cubs (61-57) open up a 2-game set at Wrigley Field Tuesday. First pitch is at 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 2-0

The White Sox’s down year continues as they have dropped 4 of their last 5 games and are just 6-14 over the last 20 games. The Sox also haven’t enjoyed interleague play much at 11-21 and are 14 1/2 games out in the AL Central with little shot at the postseason.

The Cubs are buzzin’. They are 14-6 and 20-10 over the last 20 and 30 games, respectively. They sit just 3 1/2 games behind the Milwaukee Brewers in the NL Central. The Cubbies are 20-18 in interleague play this season.

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White Sox at Cubs projected starters

RHP Touki Toussaint vs. RHP Kyle Hendricks

Toussaint (1-5, 4.27 ERA) makes his 8th start and 12th appearance. He has a 1.40 WHIP, 6.2 BB/9 and 9.1 K/9 in 46 1/3 innings with the White Sox and the Cleveland Guardians.

  • Last start: Loss, 5 IP, 4 ER, 6 H, 5 BB, 9 K last Tuesday against New York Yankees
  • 2023 home/road splits: 0-3, 5.47 ERA, 1.60 WHIP, 8.5 K/9 in 4 starts and 2 relief appearances on the road vs. 1-2, 2.70 ERA, 1.15 WHIP, 9.9 K/9 in 3 starts and 2 relief appearances at home

Hendricks (4-6, 3.96 ERA) makes his 16th start. He has a 1.12 WHIP, 1.5 BB/9 and 5.9 K/9 in 86 1/3 innings.

  • Last start: No-decision, 5 IP, 2 ER, 5 H, 2 BB, 6 K Wednesday against New York Mets
  • Last 5 starts vs. White Sox: 1-3, 6.43 ERA, 1.43 WHIP, 20 K in 28 IP

White Sox at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:23 a.m. ET.

  • Moneyline (ML): White Sox +140 (bet $100 to win $140) | Cubs -165 (bet $165 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-140) | Cubs -1.5 (+115)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

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White Sox at Cubs picks and predictions

Prediction

Cubs 6, White Sox 3

Moneyline

The Cubs won the first 2 games of the season series 10-7 and 7-3 in late July at Guaranteed Rate Field. The Baby Bears have taken 2 of 3 games from the Toronto Blue Jays and Atlanta Braves over their last 3 series, so they have beaten some impressive teams, although they did drop 2 of 3 games to the New York Mets between those series.

The Cubs aren’t as heavy favorites as I would expect, and I would consider taking them at -165. I’m looking a little bigger, though. Head to the Win/Total section and take the CUBS AND OVER 5.5 (+105) for a plus-money payout.

Run line/Against the spread

The Cubs are 32-28 on the RL at home, but I’d want a little more than +115 to pick them on a multi-run win here. We’re already getting +105 on the Cubs and Over 5.5 so if this were to swell up to +130 or more I’d throw it down.

PASS.

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Over/Under

The White Sox are 4-6 O/U over the last 10 games, and the Cubs are 5-5. Both of the previous games went Over and the Over is 6-3-1 in the last 10 meetings in this series. Toussaint has allowed 4 ER or more in 4 of his last 5 starts, and Hendricks has allowed 9 ER in 9 innings over his last 2 starts.

I like the OVER 8.5 (-115).

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Chicago Cubs at Chicago White Sox odds, picks and predictions

Analyzing Saturday’s Chicago Cubs at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Chicago Cubs (18-26) travel crosstown to play the Chicago White Sox (22-22) Saturday to start a 2-game interleague series at Guaranteed Rate Field. First pitch is set for 7:15 p.m. ET (FOX). Let’s analyze Tipico Sportsbook‘s lines around the Cubs vs. White Sox odds with MLB picks and predictions.

Both teams had Friday off. The Cubs are coming off a split of a 4-game series at the Cincinnati Reds early in the week. They are 4-6 in their last 10 games.

The White Sox lost the rubber match of their 3-game home set vs. the Boston Red Sox Thursday. Prior to that series, Chicago took 2 of 3 at the New York Yankees. The White Sox are 5-5 in their last 10.

Season series: White Sox lead 2-0

Cubs at White Sox projected starters

RHP Keegan Thompson vs. RHP Johnny Cueto 

Thompson is 4-0 with a 1.54 ERA, 1.00 WHIP, 2.6 BB/9 and 8.0 K/9 in 35 IP over 2 starts and 8 relief appearances.

  • Last start: 7-0 home win vs. the Pittsburgh Pirates May 17 with 5-scoreless IP, 4 H, 0 BB and 5 K.
  • Pitched once since then, picking up a win after 3 innings of relief Sunday against the visiting Arizona Diamondbacks. He allowed 1 run on 2 hits with no walks, while striking out 4.

Cueto is 0-0 with a 0.00 ERA (12 IP, 0 ER), 8 H, 4 BB and 12 K in 2 starts.

  • Last start: No-decision in Chicago’s 3-1 win at the Yankees Sunday with 6-scoreless IP, 6 H, 2 BB and 5 K.
  • 2021 vs. the Cubs: One start, a 4-3 loss with San Francisco Giants at Oracle Park. Surrendered 4 runs (3 earned) on 6 hits and 2 walks in 4 1/3 IP with 4 strikeouts.

Cubs at White Sox odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 4:02 p.m. ET.

  • Money line (ML): Cubs +122 (bet $100 to win $122) | White Sox -150 (bet $150 to win $100)
  • Run line (RL)/Against the spread (ATS): Cubs +1.5 (-170) | White Sox -1.5 (+135)
  • Over/Under (O/U): 7.5 (O: -130 | U: +105)

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Cubs at White Sox picks and predictions

Prediction

Cubs 5, White Sox 2

Money line

BET CUBS (+122).

There’s reverse-line movement (RLM) in their direction, the Cubs hit better against right-handed pitching and have a better bullpen than the White Sox.

More than 80% of the action is on the White Sox, per Pregame.com, but their ML has fallen from a -161 opener, which is suspicious, to say the least. This RLM is even more suspect considering the White Sox are 7-1 vs. the Cubs in their last 8 head-to-head meetings.

The Cubs have mediocre advanced-hitting numbers vs. right-handed pitching but the White Sox are dreadful. The White sox rank 26th in wRC+ (84), 27th in wOBA (.279), 26th in BB/K rate (0.29) and 29th in hard-hit rate (25.6%) against righties, according to FanGraphs.

Thompson serves as a “spot” starter, so the Cubs could get 5 or more innings of work from the bullpen, which is their strength. Cubs relievers are 1st in xFIP (3.22), per FanGraphs, and have much better swing-and-miss numbers and contact rates than the White Sox’s bullpen.

BET CUBS (+122).

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Run line/Against the spread

PASS.

Cubs +1.5 (-175) is out of my price range, but I wouldn’t rule out parlaying this with another similarly priced line for a better payout. The Cubs are 13-5 RL as road underdogs and the White Sox are just 8-14 RL at home.

Over/Under

LEAN to the UNDER 7.5 (+105).

There’s RLM headed south of the total, per Pregame.com, Thompson has been dealing this year, the Cubs have a good bullpen and the White Sox lineup has struggled vs. righties.

It’s only a LEAN because the Over is 7-3-1 O/U in their last 11 meetings and we have some money tied up in the Cubs’ ML.

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Chicago Cubs at Chicago White Sox odds, picks and prediction

Analyzing Sunday’s Chicago Cubs at Chicago White Sox odds and lines, with MLB picks and predictions.

The Chicago Cubs (57-74) and Chicago White Sox (75-56) play the rubber match of a three-game series Sunday at Guaranteed Rate Field. First pitch is scheduled for 2:10 p.m. ET. Let’s analyze the lines around the Cubs vs. White Sox odds with MLB picks and predictions.

Season series: White Sox lead 4-1

The Cubs, who were +230 underdogs, shocked the White Sox 7-0 Saturday. RHP Alec Mills tossed 8 1/3 scoreless innings, rookie 3B Patrick Wisdom hit two home runs and LF Rafael Ortega added a grand slam as the Cubs rebounded from Friday’s 17-13 loss.

RHP Kyle Hendricks is projected to start the series finale for the Cubs. He is 14-5 with a 4.09 ERA (151 2/3 IP, 69 ER), 1.33 WHIP, 6.7 K/9 and 2.0 BB/9 in 26 starts this season.

  • Last outing: No-decision, 7 IP, 4 ER, 9 H, 0 BB, 6 K in 6-4 home win vs. Colorado Rockies Monday
  • Career vs. White Sox: 1-4, 3.65 ERA (49 1/3 IP, 20 ER), 1.34 WHIP, 8.4 K/9 in nine starts

RHP Dylan Cease is projected to start for the Sox. He is 10-6 with a 3.92 ERA (137 2/3 IP, 60 ER), 1.23 WHIP, 11.6 K/9 and 3.5 BB/9 in 26 starts.

  • Last outing: Win, 7 IP, 1 ER, 4 H, 1 BB, 7 K in 5-2 win at Toronto Blue Jays Tuesday
  • Career vs. Cubs: 1-2, 5.74 ERA (15 2/3 IP, 10 ER), 14 H, 8 BB and 20 K in three starts

Cubs at White Sox odds, lines, picks and prediction

MLB odds courtesy of Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 8:19 a.m. ET.

  • Money line: Cubs +180 (bet $100 to win $180) | White Sox -230 (bet $230 to win $100)
  • Against the spread/ATS: Cubs +1.5 (-110) | White Sox -1.5 (-110)
  • Over/Under: 8.5 (O: -125 | U: +100)

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Prediction

White Sox 7, Cubs 2

Money line (ML)

BET WHITE SOX (+230) to WIN a HALF UNIT. I typically don’t like backing a big favorite, but we have a first-place team in the White Sox (AL Central) facing a Cubs team that resembles a Triple-A club.

Sure, the Cubs won Saturday as Mills shut down the White Sox. That won’t happen Sunday against Cease, who is 3-0 with a 3.09 ERA (35 IP, 12 ER) across his last six starts.

He already beat the Cubs this season, striking out 10 in a 9-3 victory at Wrigley Field Aug. 8.

Plus, the Sox are 43-24 at home and the Cubs are 24-42 on the road.

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Run line/Against the spread (ATS)

ATS records: White Sox 67-64 | Cubs 67-64

BET WHITE SOX -1.5 (-110) to WIN 1 UNIT.

They covered the spread in all four of their victories vs. the Cubs this season, winning by scores of 8-6, 4-0, 9-3 and 17-13.

The Sox are also 31-24 ATS after a loss, while the Cubs are 26-30 ATS after a W.

The South Siders rank fifth with a .253 team batting average and are seventh in runs per game (4.97).

The Cubs are hitting .231 to rank 28th and average 4.26 runs per game, ranking 21st.

Over/Under (O/U)

O/U records: White Sox 59-64-8 | Cubs 57-66-8

There are too many conflicting trends.

Both teams have cashed more Under tickets than Over bets in 2021, but the Over is 3-2 in their five head-to-head meetings.

Both starters are Over pitchers – Hendricks’ O/U is 16-10, Cease is 13-11 – but the Under is 7-4-3 in the last 14 games for the White Sox.

I’ll PASS and focus on the White Sox ML and ATS wagers, basically making them my STRONGEST PLAY – 1½ times your usual wager.

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JOHNNY’S RECORD W-L SP ROI
SINCE JULY 8 21-13 9-5 +8.157
*SP: Strongest plays; ROI: Return on investment

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Chicago Cubs at Chicago White Sox odds, picks and prediction

Analyzing Saturday’s Chicago Cubs at Chicago White Sox odds and lines, with MLB picks and predictions.

The Chicago Cubs (56-74) play the second game of a three-game Crosstown Classic set with the Chicago White Sox (75-55) Saturday. First pitch from Guaranteed Rate Field is set for 7:10 p.m. ET. Let’s analyze the lines around the Cubs vs. White Sox odds with MLB picks and predictions.

Cubs RHP Alec Mills (5-6, 4.76 ERA) makes his 14th start and 26th appearance. He has a 1.49 WHIP, 2.5 BB/9 and 6.9 K/9 through 81 1/3 IP.

  • Has a 4.64 ERA over his last seven starts. The Cubs are 1-6 in those games.
  • Owns a 4.23 ERA across 61 2/3 IP as a starter while being hampered by a .345 BABIP.

White Sox RHP Lance Lynn (10-3, 2.20 ERA) makes his 24th start. He has a 1.05 WHIP, 2.8 BB/9 and 10.0 K/9 through 130 2/3 IP.

  • His 2.20 ERA and 6.7 H/9 lead the American League amongst qualified pitchers.
  • Has allowed more than 1 ER just twice in his last 10 games. Has a 2.29 ERA over 55 IP in that span.

Cubs at White Sox odds, lines, picks and prediction

MLB odds courtesy of Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 12:20 p.m. ET.

  • Money line: Cubs +230 (bet $100 to win $230) | White Sox -300 (bet $300 to win $100)
  • Against the spread/ATS: Cubs +2.5 (-130) | White Sox -2.5 (+105)
  • Over/Under: 8.5 (O: -130 | U: +105)

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Prediction

White Sox 7, Cubs 3

Money line (ML)

The White Sox are almost certainly the correct side here as they are significantly better than the Cubs at the plate, in relief pitching and in Saturday’s starting pitching matchup.

Despite that being the case, it’s not really a good decision to risk three times your return as a standalone bet.

PASS on the money line, and seek value elsewhere.

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Run line/Against the spread (ATS)

The White Sox have a sizable advantage over the Cubs in this one with AL Cy Young-favorite Lynn on the mound. The Sox’s ace faced the crosstown-rival Cubs Aug. 6, and held them to 1 ER on 4 H and 2 BB across 6 IP while adding 8 K. There is no reason to believe he won’t produce similar numbers Saturday.

They also have a sizable advantage at the plate. The White Sox are a top-10 unit against right-handed pitchers in wRC+, wOBA and OPS; the Cubs rank in the bottom eight of the league in all three categories.

Things get no better for the Cubs when examining the relievers. They have the ninth-worst xFIP and the worst ERA through the second half of the season. They are also coming off a bullpen game Friday where they used seven relievers.

BACK the WHITE SOX -2.5 (+105). If you don’t like the added run, and if you don’t mind a bit of extra juice, you can play WHITE SOX -1.5 (-140) on the ALTERNATE RUN LINE.

Over/Under (O/U)

I fully anticipate the White Sox to get to the Cubs again Saturday. They’ve scored 38 runs through the first four games of the season series and had 21 through the first three games before Friday’s outburst.

We shouldn’t need too much from the Cubs to see this one go OVER 8.5 (-130).

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Chicago Cubs at Chicago White Sox Team odds, picks and prediction

Analyzing Friday’s Chicago Cubs at Chicago White Sox odds and lines, with MLB picks and predictions.

The Chicago Cubs (56-73) kick off a five-game road trip Friday night with the first game in a three-game series against the AL Central-leading Chicago White Sox (74-55). First pitch Friday night is at 8:10 p.m. ET at Guaranteed Rate Field. Let’s analyze the lines around the Cubs vs. White Sox odds with MLB picks and predictions.

Cubs RHP Keegan Thompson (3-3, 2.42 ERA) makes his third major-league start. He has a 1.32 WHIP, 4.8 BB/9 and 8.9 K/9 through 44 2/3 IP.

  • Thompson is making consecutive starts for the first time this season. He had one start May 4 and his most recent Aug. 28.
  • In his last start, he took the loss, allowing two runs in four innings.

White Sox LHP Dallas Keuchel (8-7, 4.71 ERA) makes his 25th start. He has a 1.36 WHIP, 3.1 BB/9 and 5.4 K/9 through 135 2/3 IP.

  • The White Six have lost five of his last six starts.
  • He has 12 appearances that he has allowed two earned runs or less. He has nine where he has allowed four or more. He last five starts have alternated between good and bad with his last one being bad. He allowed six runs on nine hits in five innings.

Cubs at White Sox odds, lines, picks and prediction

MLB odds courtesy of Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 7:50 a.m. ET.

  • Money line: Cubs +180 (bet $100 to win $180) | White Sox -220 (bet $220 to win $100)
  • Against the spread/ATS: Cubs +1.5 (-112) | White Sox -1.5 (-108)
  • Over/Under: 9.5 (O: +105 | U: -130)

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Prediction

White Sox 6, Cubs 3

Money line (ML)

The Cubs are 23-41 on the road this season and have lost 12 of their last 19 road games. They are 0-3 against the Sox this season getting swept at Wrigley Field Aug. 6-8.

The White Sox have the second-most home wins in the majors with 42 and are 45-22 against teams that are under .500. If Keuchel continues his trend of good start-bad start every other appearance, he will be very good tonight.

Take the WHITE SOX (-220).

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Run line/Against the spread (ATS)

Both teams have an identical 66-63 ATS record this season, although the White Sox are an average +0.2 ATS while the Cubs are -0.6.

The Cubs have covered the spread in 59.4% of their road games this season. However, they are 5-14 ATS in their last 19 games and failed to cover the spread in any of their three games against the White Sox this season.

The White Sox are 33-31 ATS at home. They are only 6-10 ATS in their last 16 games.

Take the WHITE SOX -1.5 (-108).

Over/Under (O/U)

Two of the three games they played against each other earlier this month had double-digit totals.

52.5% of the games played at Guaranteed Rate Field have hit the Over this season.

However, neither of Thompson’s two starts this season have had totals of 10 runs or more, and only two of Kuechel’s last six starts have.

Only three of the Sox’s last 12 games have finished with 10 runs or more.

Take UNDER 9.5 (-130).

For more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

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Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage. This information is for entertainment purposes only. We make no representations or warranties as to the accuracy, completeness, or reliability of any content.

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