Chicago Cubs at Chicago White Sox odds, picks and predictions

Analyzing Wednesday’s Chicago Cubs at Chicago White Sox odds and lines, with MLB expert picks, predictions and best bets.

The Chicago Cubs (49-51) took down the Chicago White Sox (41-61) on Tuesday and they’ll meet again on Wednesday. First pitch is set for  8:10 p.m. ET at Guaranteed Rate Field. Let’s analyze BetMGM Sportsbook’s lines around the Cubs vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 1-0 after Tuesday’s 7-3 win

The Cubs have won 6 of their last 7 games and are still hanging around in the battle for a playoff berth. They are now 6 games back in the NL Central despite being the only team with a positive run differential (+45). They are 5 games back in the Wild-Card race.

The White Sox have had a tough season and continue to struggle, as they have dropped 6 of their last 7 games to slip 20 games under .500 on the season. They are 4th in the AL Central, 12 1/2 games back.

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Cubs at White Sox projected starters

RHP Marcus Stroman vs. RHP Lance Lynn

Stroman (10-7, 3.09 ERA) makes his 22nd start. He has a 1.14 WHIP, 3.4 BB/9 and 7.7 K/9 in 122 1/3 innings.

  • Last start: Loss, 3 2/3 IP,  5 R (4 ER), 7 H, 4 BB, 4 K in 7-2 loss at St. Louis last Thursday
  • 2023 road stats: 4-2, 3.11 ERA (55 IP, 19 ER) in 10 starts
  • Career vs. White Sox: 2-4, 4.27 ERA (59 IP, 28 ER) in 10 starts;  last faced them in 2022.
  • Has been outstanding for most of the season, but has fallen on hard times lately with a 6.46 ERA over his last 5 starts. He has averaged less than 5 IP per start during that span while posting a 4.6 K/9

Lynn (6-9, 6.18 ERA) makes his 21st start. He has a 1.44 WHIP, 3.4 BB/9 and 10.9 K/9 in 115 innings.

  • Last start: Loss, 6 2/3 IP, 9 R (6 ER), 3 BB, 6 K, and 4 HR allowed in a 9-4 loss at Minnesota on Friday
  • 2023 home stats: 2-4, 6.11 ERA (45 2/3 IP, 31 ER) with a 1.8 HR/9 and 11.2 K/9 in 8 starts
  • Career vs. Cubs: 6-8, 5.11 ERA (118 IP, 67 ER) in 23 appearances (22 starts); last faced the Cubs in 2021
  • Has been very homer-prone; his HR/9 sits at 2.2 with a league-leading 28 HR allowed

Cubs at White Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:28 a.m. ET.

  • Moneyline (ML): Cubs -120 (bet $120 to win $100) | White Sox +100 (bet $100 to win $100)
  • Run line (RL)/Against the spread (ATS): Cubs -1.5 (+135) | White Sox +1.5 (-165)
  • Over/Under (O/U): 9 (O: -105 | U: -115)

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Cubs at White Sox picks and predictions

Prediction

Cubs 5, White Sox 3

Moneyline

Stroman has struggled over his last few starts, but is in a good spot to get back on track. The White Sox are 28th in wRC+ vs. right-handed pitching and are 27th in runs per game at home (4.00). Back the CUBS -120, as they have been rolling lately.

Run line/Against the spread

While the Sox have lost 6 of their last 7 games, 3 of those have been by just a single run. Lynn has been prone to blowups, but his skills have still been pretty strong, especially lately, as he boasts a 12.7 K/9 and 18.6% Swinging Strike Rate (SwK%) over his last 6 starts. This game should stay pretty close so PASS on the run line.

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Over/Under

The White Sox have scored 4 runs or fewer in 5 of their last 6 contests. Lynn is sporting a bloated ERA, but is due for some better luck, as he has been hurt by a .322 BABIP, a 63.7% LOB%, and 21.5% HR/F. This game should sneak in UNDER 9 (-115).

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