Indianapolis Colts at New England Patriots odds, picks and predictions

Analyzing Sunday’s Indianapolis Colts at New England Patriots odds and lines, with expert NFL picks, predictions and best bets.

The Indianapolis Colts (3-4-1) hope to end a 2-game losing streak Sunday as they face the New England Patriots (4-4) on the road in Week 9. Kickoff at Gillette Stadium in Foxboro is at 1 p.m. ET (CBS). Below, we analyze Tipico Sportsbook‘s lines around the Colts vs. Patriots odds, and make our expert NFL picks and predictions.

The Colts lost last week 17-16 to the Washington Commanders as 3-point favorites. QB Sam Ehlinger started and passed for 201 yards without an interception, but the Commanders rallied from a 16-7 deficit with 10 points in the 4th quarter to win the game.

The Patriots beat the New York Jets 22-17 last week, covering the 3-point spread. They only had 288 yards of offense but the defense had 3 interceptions. Kicker Nick Folk made 4 field goals in the game.

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Colts at Patriots odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:08 p.m. ET.

  • Moneyline (ML): Colts +190 (bet $100 to win $190) | Patriots -230 (bet $230 to win $100)
  • Against the spread (ATS): Colts +5.5 (-112) | Patriots -5 (-108)
  • Over/Under (O/U): 40 (O: -110 | U: -110)

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Colts at Patriots key injuries

Colts

  • CB Tony Brown (hamstring) out
  • OL Dennis Kelly (calf, ankle) questionable
  • QB Matt Ryan (shoulder) out
  • LB Grant Stuard (pectoral)  out
  • RB Jonathan Taylor (ankle) out

Patriots

  • C David Andrews (concussion) out
  • DL Christian Barmore (knee) questionable
  • OT Marcus Cannon (concussion) out
  • S Kyle Dugger (ankle) questionable
  • RB Damien Harris (illness) questionable
  • CB Jack Jones (illness) questionable
  • WR DeVante Parker (knee) out
  • RB Pierre Strong Jr. (hamstring) questionable
  • LB Josh Uche (hamstring) questionable
  • DE Deatrich Wise Jr. (ankle) questionable

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Colts at Patriots picks and predictions

Prediction

Patriots 20, Colts 17

Moneyline

The Patriots are still not doing great offensively, but they face a Colts team without their top running back and with Ehlinger at quarterback. The Pats have won 3 of their last 4 games and have not allowed more than 17 points in the last month.

The Colts have 6 games with fewer than 20 points.

There is too much for them to overcome, but betting the Pats to win outright is too expensive.

PASS. 

Against the spread

The Pats average only 17.2 points per game with Mac Jones starting at quarterback.

However, as noted, the Colts have 6 games scoring fewer than 20 points.

Indy is No. 7 in points allowed, giving up only 19.6 per game.

It should be a low-scoring, close game that the Pats control.

BET COLTS +5.5 (-112).

Over/Under

No Taylor means an offensive struggle for the Colts and the Pats’ scoring average with Jones starting has been noted. Don’t expect a lot of points.

BET UNDER 40 (-110).

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