Indianapolis Colts at Jacksonville Jaguars odds, picks and predictions

Analyzing Sunday’s Indianapolis Colts at Jacksonville Jaguars odds and lines, with expert NFL picks and predictions.

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The Indianapolis Colts (3-2) and Jacksonville Jaguars (3-2) meet Sunday at EverBank Stadium. Kickoff is set for 1 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Colts vs. Jaguars odds, and make our expert NFL picks and predictions.

The Colts, having won 3 of their last 4, picked up a 23-16 home win over the Tennessee Titans as 2.5-point road underdogs. The Under (43.5) cashed in. They finished the game without rookie QB Anthony Richardson, who got hurt and has since been placed on injured reserve.

The Jaguars spent the last 2 weeks in London, picking up 2 wins. Last week, they upset the Buffalo Bills 25-20 as 5.5-point underdogs. The Under (48.5) hit in the win. They were the road team in that game. The week prior, they beat the Atlanta Falcons 23-7, covering as 3-point “home” favorites.

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Colts at Jaguars odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:35 p.m. ET.

  • Moneyline (ML): Colts +165 (bet $100 to win $165) | Jaguars -200 (bet $200 to win $100)
  • Against the spread (ATS): Colts +4.5 (-115) | Jaguars -4.5 (-105)
  • Over/Under (O/U): 44 (O: -110 | U: -110)

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Colts at Jaguars key injuries

Colts

  • TE Mo Alie-Cox (concussion) available
  • Ryan Kelly (ankle/foot) questionable
  • T Braden Smith (foot, wrist, hip) out

Jaguars

  • LB Devin Boyd (thumb) questionable
  • WR Zay Jones (knee) out
  • OL Walker Little (knee) out

Colts at Jaguars picks and predictions

Prediction

Jaguars 27, Colts 20

Moneyline

The Jaguars already beat the Colts 31-21 in Indianapolis in Week 1. They have won 2 straight games but have not won yet in their home stadium this season.

The Colts are 1-0 this season with Gardner Minshew starting at quarterback. They are 2-0 on the road this season. In their 3 wins this season, they have not allowed more than 20 points.

The Jaguars have averaged 26.3 points per game in their 3 wins.

The Jags must overcome being without Jones and Little on offense. Their defense held Buffalo to only 20 points and the Falcons to only 7.

The Jaguars should win, but at -200 odds, PASS on the moneyline.

Against the spread

Both teams are 3-2 ATS this season, covering the spread in their 3 wins and failing to do so in their 2 losses.

The Colts have not lost by fewer than 6 points. The Jaguars’ 3 wins have been by at least 5 points.

Jacksonville is 2-1 ATS when favored. The Colts have been the underdogs in every game this season.

BET JAGUARS -4.5 (-105).

Over/Under

The Week 1 matchup between the 2 teams had 52 total points.

Indy’s 2 losses have had 52 total points each.

Two of Jacksonville’s 3 wins have had at least 45 points.

BET OVER 44 (-110).

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Indianapolis Colts at Jacksonville Jaguars odds, picks and predictions

Analyzing Sunday’s Colts at Jaguars odds and lines, with expert NFL picks, predictions and best bets.

The Indianapolis Colts (0-0-1) and Jacksonville Jaguars (0-1) continue their AFC South rivalry Sunday at TIAA Bank Field in Jacksonville, Fla. Kickoff is set for 1 p.m. ET (CBS). Below, we analyze Tipico Sportsbook‘s lines around the Colts vs. Jaguars odds, and make our expert NFL picks and predictions.

The Colts tied the Houston Texans 20-20 in Week 1 after both squads failed to score in overtime. QB Matt Ryan had a solid day with 352 yards passing, 1 TD and 1 INT. He found WR Michael Pittman Jr. for 121 of those yards on 9 receptions. RB Jonathan Taylor continued to show why he’s the NFL’s top back, earning 161 yards and a TD on 31 carries.

The Jaguars lost on the road last week 28-22 to the Washington Commanders. Jacksonville led 22-14 in the 4th quarter, but allowed 14 unanswered points in the final 10 minutes. Second-year QB Trevor Lawrence passed for 275 yards and 1 TD and 1 INT. His favorite target was newly-acquired WR Christian Kirk, who had 6 receptions for 117 yards.

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Colts at Jaguars odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:26 a.m. ET.

  • Money line (ML): Colts -165 (bet $165 to win $100) | Jaguars +140 (bet $100 to win $140)
  • Against the spread (ATS): Colts -3.5 (+102) | Jaguars +3.5 (-125)
  • Over/Under (O/U): 44.5 (O: -112 | U: -108)

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Colts at Jaguars key injuries

Colts

  • WR Alec Pierce (concussion) out
  • WR Michael Pittman Jr. (quad) out
  • DT DeForest Buckner (hip) questionable
  • CB Kenny Moore II (hip) questionable

Jaguars

  • None

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Colts at Jaguars picks and predictions

Prediction

Jaguars 24, Colts 20

Money line

If you’re ever going to play Jacksonville as an underdog, right now may be the perfect time to do it. The Colts are already banged up just 2 weeks into the season, missing 2 of their top WRs in Pittman and Pierce. They’ll rely on the running game with Taylor, but that 1-dimensional offensive approach may not be enough to take out the Jags on the road.

I like the JAGUARS +140.

Against the spread

If you’re not quite sold on taking the Jags straight up, that’s okay. Play the JAGUARS +3.5 (-125). Both matchups from each squad last week suggest they’ll play teams close, plus this is a divisional matchup where each team will throw out its best. Recent history shows the Jags should cover as well — they’re 4-0 ATS vs. the Colts in their last 4 matchups.

Over/Under

I try to avoid over/unders on total points at the beginning of the season until teams and trends are more established. That said, if you’re dying to put something down on this, I’d lightly lean toward UNDER 44.5 (-108) for the sole fact that neither offense appears to be that good (yet). The Colts will run the ball more which means draining more clock, while the Jaguars have yet to do anything to show that their offense can consistently put up big points.

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Indianapolis Colts at Jacksonville Jaguars odds, picks and prediction

Analyzing Sunday’s Indianapolis Colts at Jacksonville Jaguars odds and lines, with expert NFL picks, predictions and best bets.

On Sunday, the Indianapolis Colts (9-7) travel to Florida to take on the Jacksonville Jaguars (2-14). Kickoff at EverBank Field is slated for 1 p.m. ET. Below, we look at the Colts vs. Jaguars odds and lines, and make our best NFL picks, predictions and bets.

The Colts are entering this game in a must-win scenario. If the Colts lose, they’re more than likely out (they could still get in with a Raiders/Chargers win and a Steelers/Ravens tie). Basically, they need to win.

Indy has been better than preseason expectations, covering 10 of its 16 games. The Jags, on the other hand, have had a fiasco of a season and have covered just 4 times this season.

Jacksonville’s star RB James Robinson has been out after sustaining a season-ending injury. With QB Trevor Lawrence set to start, the Jags have failed to cover 7 straight games including twice as double-digit underdogs.

Colts at Jaguars odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:30 a.m. ET.

  • Money line: Colts -1200 (bet $1200 to win $100) | Jaguars +700 (bet $100 to win $700)
  • Against the spread (ATS): Colts -14.5 (-108) | Jaguars +14.5 (-112)
  • Over/Under (O/U): 43.5 (O: -110 | U: -110)

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Colts at Jaguars key injuries

Colts

  • CB Xavier Rhodes (hamstring) out
  • DT DeForest Buckner (knee) questionable

Jaguars

  • TE James O’Shaughnessy (knee) out
  • TE Dan Arnold (knee) questionable

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Colts at Jaguars odds, lines, predictions and picks

Prediction

Colts 31, Jaguars 10

Money line

PASS on the money line. A -1200 in the NFL has no value. Similarly, the Colts are in a must-win scenario and are the far better team, giving the Jaguars +700 also little value.

Against the spread

BET on the COLTS -14.5 (-108).

While the Colts are a bona fide playoff contender, this is more a fade on the Jags. The two times in the past two months that they’ve been double-digit underdogs, they lost by 30 and 40.

With an atrocious run defense, the Colts, who have the league’s rushing yards leader in Jonathan Taylor, should be able to have their way. The Jags rank 25th in opponents’ rushing yards per game.

They also rank dead last in turnovers. Indy ranks 2nd in defensive turnovers, so it’ll more than be giving great field position a couple of times. With that in mind, I’d back the COLTS -14.5 (-108).

Over/Under

“LEAN” to the UNDER 43.5 (-110). The Jags haven’t been able to move the ball for the better part of the season, and they’ve covered the Over just 5 times.

Jacksonville ranks at the bottom of the league in points per game and will face a Colts defense that knows the stakes this game has.

With that in mind, I’d lean the Under as the Colts should heavily limit the Lawrence-led Jags.

Also see: All Week 18 odds and lines

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