Indianapolis Colts at San Francisco 49ers odds, picks and predictions: Player prop bets

Analyzing the Indianapolis Colts at San Francisco 49ers Week 7 matchup and offering up expert picks and predictions on the top player prop bets.

The Indianapolis Colts (2-4) stop by Levi’s Stadium to play the San Francisco 49ers (2-3) on Sunday Night Football in Week 7. Kickoff is scheduled for 8:20 p.m. ET. Below, we look at the Colts vs. 49ers prop bet odds and lines, and make our best NFL picks, predictions and bets.

Indy handled business last weekend by crushing the Houston Texans 31-3 as 11.5-point home favorites. Colts RB Jonathan Taylor rushed for 145 yards on just 14 carries with two rushing TDs. QB Carson Wentz completed 11-of-20 passes for 223 yards and a 2 TD:0 INT ratio.

San Francisco had a bye Week 6 and announced earlier this week QB Jimmy Garoppolo will be starting vs. the Colts Sunday after rookie QB Trey Lance was ruled out with a knee injury.

Colts at 49ers prop bet picks and predictions

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 7:30 a.m. ET.

49ers RB Elijah Mitchell UNDER 62.5 rushing yards (-118)

If San Francisco’s offense is going to have success on Sunday Night Football then it’ll most likely have to come through the passing game.

According to Football Outsiders, Indy’s defense has the best rushing DVOA in the NFL and the Colts have played against formidable ground games. In fact, three of Indy’s opponents are in the top-10 of offensive rushing DVOA: Seattle Seahawks, Tennesee Titans and Baltimore Ravens.

Furthermore, the Colts give up the third-fewest fantasy points per game to opposing running backs and the 10th-fewest yards per rush. Also, Indy’s defense has two top-tier players in its front seven, including former 49ers DT DeForest Buckner and LB Darius Leonard.

On top of that, Mitchell’s rushing prop is bloated in the first place. Mitchell is a rookie dealing with injuries and has only played in three games, one of which he ran for more than 62.5 yards.

The team that Mitchell gained more than 62.5 rushing yards against was the Detroit Lions, who are ranked 26th by Football Outsiders in defensive rushing DVOA.

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Colts RB Jonathan Taylor Anytime Touchdown scorer (-105)

After failing to hit paydirt in his first three games, Taylor has scored five combined TDs in the last three contests. The difference in my opinion between Taylor’s production early and lately is Wentz getting comfy in his new surroundings and realizing Taylor is his best skill position player.

Moreover, Indy announced this week that WR T.Y. Hilton is sidelined with an injury for this game and the weather forecast is predicting a rainy, windy night in San Francisco.

Wentz having fewer receiving options combined with Taylor having the second-most receiving yards for the Colts and the weather conditions grounding both teams’ aerial attacks equals more Taylor reps in this game.

At nearly even money, I love the value in Jonathan Taylor‘s Anytime Touchdown prop (-105).

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Indianapolis Colts at San Francisco 49ers odds, picks and prediction

Analyzing Sunday’s Indianapolis Colts at San Francisco 49ers odds and lines, with expert NFL picks, predictions and best bets.

The Indianapolis Colts (2-4) will take on the rested San Francisco 49ers (2-3) on the road in the featured Sunday night game in Week 7. kickoff is 8:20 p.m. ET at Levi’s Stadium. Below, we look at the Colts vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.

The Colts, after losing their first three games of the season, have won two of their last three, and the one loss was in overtime against the Baltimore Ravens. They have scored at least 25 points in three straight games. QB Carson Wentz is heating up after dealing injuries to both ankles. He now has nine touchdown passes and only one interception this season, and RB Jonathan Taylor is averaging 5.4 yards per carry for 472 yards and four scores through six games.

The 49ers won their first two games of the season, only to drop their next three. They are coming off their bye week and get QB Jimmy Garoppolo back in the starting lineup after Trey Lance made his first NFL start in Week 5 in a 17-10 loss to the Arizona Cardinals.

Colts at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:00 a.m. ET.

  • Money line: Colts +155 (bet $100 to win $155) | 49ers -190 (bet $190 to win $100)
  • Against the spread (ATS): Colts +3.5 (-110) | 49ers -3.5 (-110)
  • Over/Under (O/U): 42.5 (O: -112 | U: -108)

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Colts at 49ers key injuries

Colts

  • OL Braden Smith (thumb, foot) out
  • CB Rock Ya-Sin (ankle) out
  • Julian Blackmon (Achilles) out
  • WR T.Y. Hilton (quad) questionable

49ers

  • QB Trey Lance (knee) out
  • DT Javon Kinlaw (knee) out
  • LT Trent Williams (elbow, ankle) doubtful
  • LB Marcell Harris (thumb) questionable

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Colts at 49ers odds, lines, predictions and picks

Prediction

49ers 27, Colts 21

Money line

The 49ers are just a different team with Garoppolo in the lineup. They are 24-10 in the regular season when he starts, and the one time he was healthy for a full season, he took them to the Super Bowl. Their defensive front will give Wentz problems.

Plus, coming off the bye, the 49ers have had extra time to prep and are playing at home, although they are 0-2 there this season.

Take the 49ERS (-190).

Against the spread

The Colts are 4-2 ATS this season, while the 49ers are 1-4 ATS. However, the 49ers are physical up front defensively, while the Colts will be missing one of their starting interior linemen, which will challenge the Colts’ rushing attack.

The 49ers will apply pressure to Wentz and Garoppolo, if he doesn’t get hurt again, keeps the 49ers offense on schedule.

Take the 49ERS -3.5 (-110).

Over/Under

With the Colts having scored 25 points or more in each of their last three games and the 49ers showing the ability to put points on the board – 41 against the Lions and 28 against the Packers, we can expect to see some points.

It won’t be a shootout in the 30s, but we can expect both teams to be in the 20s this weekend. Take OVER 42.5 (-112).

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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Underdog corner: 3 best NFL picks and predictions for Week 7

Assessing the NFL betting odds and lines for Week 7, with three predictions and picks for the best underdog bets to make.

Despite NFL pointspread favorites winning a second straight week, we still had a winning week here, going 2-1 with the Jacksonville Jaguars and Tennessee Titans coming through.

That’s now five winning weeks out of six as our season record moves to 13-5. Of our 13 underdog covers, 11 have won outright.

With six teams on a bye this week, it’s a shallow card to choose from, but come up with three we must. Here are our NFL underdog ATS picks and predictions of Week 7.

Also see: All Week 7 odds and lines

NFL underdog predictions: Week 7

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 5:56 a.m. ET.

Tennessee Titans +5.5 (-110) vs. Kansas City Chiefs

Over the last couple weeks:

  • The Buffalo Bills beat the Chiefs 38-20 as road underdogs in Week 5.
  • The Titans beat the Bills 34-31 as home underdogs in Week 6.
  • Now, the Chiefs are 5.5-point Week 7 road favorites over the Titans in Nashville?

An eye-catching line to be sure, but we’re not going to handicap a matchup going by results against a common foe alone.

However, the Chiefs have covered in only four of their last 17 games dating back to last season. In what should be a high-scoring affair Sunday, the mighty RB Derrick Henry and Tennessee should be able to keep it close going against a K.C. defense surrendering 133.2 rushing yards and 29.3 points per game and a league-most 6.7 yards per play.

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Indianapolis Colts +4.5 (-115) at San Francisco 49ers

QB Carson Wentz and Indy started 0-3 but have won two of its last three. The loss was a 31-25 overtime setback in Week 5 on the road against the 5-1 Baltimore Ravens.

The Colts are 4-2 against the spread (ATS) – tied for fourth best in the league.

The 49ers (2-3) are coming off a bye and are expected to have QB Jimmy Garoppolo back from injury. Still, they are 1-4 ATS overall this year and 3-9 ATS as favorites since the start of last season.

The Niners very well could win Sunday night, but expect the improving Colts to keep it within the number.

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Seattle Seahawks +4.5 (-110) vs. New Orleans Saints

In the 11 combined games involving the Saints and Seahawks this season, the underdogs have covered eight times with seven outright wins.

In addition, the home team has won all six Monday night games so far, going 5-1 ATS in process. So, Seattle was the choice to round out our underdog card.

We realize the Saints have had a bye week to prepare and the QB Geno Smith-led Seahawks are playing a second straight game without elite QB Russell Wilson.

But we’re banking on seeing more of the fight Seattle showed last week at the Pittsburgh Steelers – egged on this time by the always-raucous Seattle primetime crowd – and also one or two of the typical mistakes from Saints QB Jameis Winston to help the home team get the Monday night cover.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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