Clemson at Florida State odds, picks and predictions

Analyzing Saturday’s Clemson at Florida State odds and lines, with college football expert picks, predictions and best bets.

The Clemson Tigers (6-0, 4-0 ACC) visit the Florida State Seminoles (4-2, 2-2) Saturday in a classic ACC matchup. Kickoff from Doak Campbell Stadium is slated for 7:30 p.m. ET (ABC). Below, we analyze Tipico Sportsbook‘s lines around the Clemson vs. Florida State odds, and make our expert college football picks and predictions.

Clemson comes into this game looking to get back to the national championship for the 1st time since 2019, and wins in games like this are key to get them into the playoffs this year. This will be their 4th straight conference game and they’ve won the previous 3 over Wake Forest (51-45 in 2 OT), NC State (30-20) and last week vs. Boston College (31-3). QB DJ Uiagalelei is still looking to silence some of his critics from last season. So far on the year he is completing 64% of his passes (122 of 190 attempts) for 1,462 yards with 14 TDs and only 2 INTs.

Florida State is looking to defeat its 1st ranked opponent this season. They started their season with 4 straight wins, but have dropped their last 2 — Oct. 1 vs. #22 Wake Forest (31-21) and last week vs. #14 NC State (19-17). QB Jordan Travis is completing 62% of his passes (98 of 156 attempts) for 1,407 yards with 9 TDs and only 3 INTs.

Clemson is No. 5 in the AFCA Coaches Poll powered by USA TODAY Sports.

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Clemson at Florida State odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:03 p.m. ET.

  • Moneyline (ML): Clemson -200 (bet $200 to win $100) | Florida State +160 (bet $100 to win $160)
  • Against the spread (ATS): Clemson -3.5 (-115) | Florida State +3.5 (-107)
  • Over/Under (O/U): 51.5 (O: -105 | U: -120)

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Clemson at Florida State picks and predictions

Prediction

Clemson 35, Florida State 14

Moneyline

BET CLEMSON -200

Though pricey, this bet is your best bet. Clemson here isn’t too heavily favored for me to believe that the risk here is not worth the reward. For this game I would bet on Clemson, even as the away team. Florida State is not an easy place to play, but Clemson is used to that type of atmosphere. Florida State is a scrappy team with a lot of talent, but this Clemson team has their eyes on a  national championship, and I don’t see them losing this game.

Against the spread

BET CLEMSON -3.5 (-110)

If you’re uncomfortable with the risk of betting the moneyline in this game then this is your bet. I could very easily see Florida State putting up a fight in this game, I think the 1st half will be very close, but in the end the Tigers will show why they’re ranked 5th in the nation. The Tigers were able to beat #10 ranked NC State by 10, and that team is much better than this Florida State team. The Seminoles have proven they have some ability to score against good teams which is why I predict they will score at least 2 TDs, but that won’t be enough to make this a close game.

Over/Under

LEAN UNDER 51.5 (-120)

This is your riskiest bet. Both these offenses have the ability to score, but I have a lot of faith in Clemson’s defense to be able to string together multiple stops throughout this game. Clemson has not scored less than 30 points in any of its last 3 games, and I see that trend continuing this weekend. The only thing that worries me about this bet is the fact that Clemson allowed Wake Forest to score 45 points and NC State to score 20. While both of those teams are better than this FSU team, that causes some concern for me.

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