Cincinnati Bengals vs. Detroit Lions odds predictions pick betting line spread

The Cincinnati Bengals (3-2) travel north to take on the winless Detroit Lions (0-5) Sunday in Week 6 for a 1 p.m. ET kickoff at Ford Field (FOX). Below, we look at the Bengals vs. Lions odds and lines, and make our best NFL picks, predictions and bets.

Cincinnati is coming off a 25-22 overtime home loss as 2-point underdogs to the Green Bay Packers. The Bengals missed two late field goals – one with 26 seconds left in regulation that likely would have won it and a game-winning attempt in overtime.

Detroit also suffered a heartbreaking Week 5 loss, falling to the Minnesota Vikings 19-17. The Lions, who at least covered as 10-point underdogs, were seconds away from their first win of the season, but the Vikings kicked a game-winning, 54-yard field goal as time expired.

Detroit led 17-16 with 33 seconds to go. Minnesota was back at its own 18-yard line but hit three passes in a row for 46 yards to set up the game-winning kick.

Bengals at Lions odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 9:33 a.m. ET.

Money line: Bengals -190 (bet $190 to win $100) | Lions +155 (bet $100 to win $155)
Against the spread (ATS): Bengals -3.5 (-108) | Lions +3.5 (-112)
Over/Under (O/U): 46.5 (O: -115 | U: -115)

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Betting stats:

ATS: Bengals 2-3 | Lions 3-2
O/U: Bengals 1-4 | Lions 2-3

Bengals at Lions key injuries

Bengals

RB Joe Mixon (ankle) questionable
G D’Ante Smith (knee) out

Lions

LB Trey Flowers (knee) questionable
TE T.J. Hockenson (knee) questionable
RB D’Andre Swift (groin) questionable
RB Jamaal Williams (hip/illness) questionable

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Bengals at Lions odds, lines, predictions and picks

Prediction

Bengals 21, Lions 20

Money line

The Bengals’ -190 price is a bit steep and I wouldn’t be surprised if the Lions pull off the upset since they’re at home.

I could see sprinkling a few bucks on Detroit (+155), but I’ll PASS and focus on taking the points.

Against the spread

DETROIT +3.5 (-112) is the STRONGEST PLAY – 1½ times your usual wager.

The Lions are 2-0 ATS at home this season. They lost to the San Francisco 49ers 41-33 as 9.5-point underdogs in Week 1 and lost to the Baltimore Ravens 19-17 (on an NFL-record 66-yard field goal as time expired) as 7.5-point dogs in Week 3.

The Bengals, who are 1-1 SU/ATS on the road, are definitely headed in the right direction, especially with the LSU combination of QB Joe Burrow (1,269 passing yards, 11 TDs) and WR Ja’Marr Chase. The wideout leads all rookies in receiving yards (456) and receiving touchdowns (5).

But asking a young squad to cover 3.5 on the road against a team hungry for their first win – with a veteran QB in Jared Goff (1,303 passing yards, 7 TDs) – is a tough ask.

Only play for a Full Unit if the line drops to Cincy -3.

Over/Under

BET UNDER 46.5 (-105) to WIN 0.7 UNITS.

The Lions have played 3 Unders in a row and haven’t scored more than 17 points in their last four games.

The Bengals have played 4 Unders in a row and haven’t scored more than 24 points in regulation.

There’s no reason to believe anything changes Sunday.

Week 6 best bets

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

JOHNNY’S RECORD	W-L	SP	ROI
SINCE JULY 8	60-37	26-11	+22.816
–SP: Strongest plays; ROI*: Return on investment

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NFL pointspread favorites enjoyed their first winning week of the season in Week 5, but were unfazed here in Underdog Corner, hitting on two of our three selections to notch our fourth winning week of the season.

With the Cincinnati Bengals and Buffalo Bills cashing, it ups our 2021 record to a nice and profitable 11-4 (.733).

Let’s see if we can keep the train rolling with our NFL underdog ATS picks and predictions of Week 6.

Also see: All Week 6 odds and lines

NFL underdog predictions: Week 6

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 6:41 p.m. ET.

Jacksonville Jaguars +3.5 (-117) vs. Miami Dolphins

The NFL is serving up another London dud as the winless Jaguars take on the 1-4 Dolphins, whose only victory was a 17-16 opening-week escape at the New England Patriots.

Moreover, each side’s offense and defense rank as a bottom-five NFL unit in terms of scoring and points allowed per game.

Dolphins QB Tua Tagovailoa is hoping to play after a three-week IR stint with a rib injury, and that should provide a boost for a Miami offense which ranks 30th in passing (191.4 yards per game).

But with rookie QB Trevor Lawrence getting his NFL legs under him and the Jags owning a significant advantage in the run game with stud second-year RB James Robinson (fourth in the league with 387 yards while averaging 5.8 yards per attempt), there’s no reason why Miami should be favored by anything more than a point or two.

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Detroit Lions +3.5 (-110) vs. Cincinnati Bengals

Yep, we’re on each of the league’s winless teams this week.

Head coach Dan Campbell’s 0-5 Lions have been particularly feisty with a 3-2 record against the spread and losing two of their last three on 54-yard-plus field goals on the game’s final play.

Led by the QB Joe Burrow– WR Ja’Marr Chase LSU connection that’s already clicked for five TDs, the Bengals are 3-2. But they are also 2-3 ATS, now a road favorite for only the third time since 2018 and are in a prime look-past-the-winless-opponent spot with a game against the division-leading Baltimore Ravens looming next week.

Take the scrappy Lions and the field goal-plus.

WIN YOUR FANTASY FOOTBALL LEAGUE!

For 25 years, TheHuddle.com has been helping fantasy players just like you win. This year, it’s your turn! Custom player rankings, tools and more to give you the edge over your competition.

Use code SBW21 to take 20% OFF a new subscription. Join now!

Tennessee Titans +5.5 (-110) vs. Buffalo Bills

Speaking of red-flag letdown spots, the 4-1 Bills are playing in their second straight primetime road game after notching a massive revenge 38-20 win at the host Kansas City Chiefs Sunday night.

The Tennessee defense, ranked 24th with 26.0 points allowed per game, is a clear concern facing Bills QB Josh Allen and the league’s highest-scoring offense (34.4 points). But if the 3-2 Titans can avoid turnovers (Buffalo has an NFL-most 15 takeaways) and get league rushing leader RB Derrick Henry (640 yards, 7 TDs) and the play-action game going with capable QB Ryan Tannehill, the hosts should be able to keep this Monday night matchup close.

If you hold off until closer to kickoff, you might even be able to catch more points with the Titans as the line has already gone up two full points after opening at Bills -3.5.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

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