Chicago White Sox at Chicago Cubs odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (15-46) battle the Chicago Cubs (30-31) in the finale of a short 2-game series  Wednesday. First pitch from Wrigley Field is scheduled for 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 1-0

The White Sox have lost 12 games in a row after falling 7-6 Tuesday as +247 road underdogs. DH Korey Lee and 3B Lenyn Sosa each had 2 RBIs during a 5-run 4th inning as the Sox jumped out to a 5-0 lead.

After the Cubs tied it in the bottom of the 6th, CF Luis Robert Jr. put the Sox back in front with a solo homer in the 7th, but Cubs LF Ian Happ hit a 2-run, go-ahead double in the 8th for the final score. PH/1B Patrick Wisdom and 3B Christopher Morel both homered as the Cubs (-278) fought their way back, helping the Over (9.5) hit.

White Sox at Cubs projected starters

RHP Erick Fedde vs. RHP Jameson Taillon

Fedde (4-1, 3.12 ERA) makes his 13th start. He has a 1.18 WHIP, 2.9 BB/9 and 8.6 K/9 through 69 1/3 innings.

  • Last start: No-decision, 5 IP, 4 ER, 9 H, 4 BB, 8 K in 12-5 loss at Milwaukee Brewers Friday
  • White Sox are 5-7 in his 12 starts with Fedde allowing 4 or more ER in 2 of his last 3 outings
  • Career vs. Cubs: 0-0, 5.56 ERA (11 1/3 IP, 7 ER), 12 H, 5 BB, 15 K in 2 starts — last outing in 2021

Taillon (3-2, 2.84 ERA) makes his 9th start. He has a 1.26 WHIP, 2.4 BB/9 and 5.9 K/9 through 44 1/3 innings.

  • Last start: No-decision, 6 IP, 3 ER, 6 H, 1 BB, 4 K in 6-4 loss at Brewers Thursday
  • Cubs are 4-4 in his 8 starts, but they are 0-4 in his last 4. He has allowed 3 ER in each of his last 3 outings
  • Career vs. White Sox: 0-0, 2.38 ERA (22 2/3 IP, 6 ER), 1.15 WHIP, 7.9 K/9 in 4 starts

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White Sox at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:10 a.m. ET.

  • Moneyline (ML): White Sox +145 (bet $100 to win $145) | Cubs -175 (bet $175 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-130) | Cubs -1.5 (+105)
  • Over/Under (O/U): 9 (O: -120 | U: +100)

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White Sox at Cubs picks and predictions

Prediction

Cubs 6, White Sox 4

Moneyline

BET CUBS (-175).

While the White Sox have lost 12 in a row, the Cubs are just 3-9 in their last 12 games. The Cubs still have a clear advantage, however with Taillon on the mound, in which the Cubs have lost his last 4 starts, and less profit to be made on a win, do not make a large wager on the outcome.

Run line/Against the spread

PASS.

With both teams at a combined 3-21 over each of their last 12 games, it is evident neither team has played well enough to merit a bet on the run line. Both have struggled defensively and only seen minimal success on offense.

Over/Under

BET OVER 9 (-120).

The Over is 5-3-2 in the last 10 games for the White Sox, including in back-to-back outings. The pitching staff has allowed 4 or more runs in 11 of its last 12, and 5 or more in 9 of those 12.

The Cubs have hit the Over in 7 of their last 10, including 6 of their last 7. They have scored 4 or more in 6 of their last 7, and 6 or more in 4 of their last 7, while allowing 5 or more in 8 of their last 10.

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Chicago White Sox at Chicago Cubs odds, picks and predictions

Analyzing Tuesday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The Chicago White Sox (15-45) and Chicago Cubs (29-31) open a 2-game set at Wrigley Field Tuesday. First pitch is scheduled for 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Cubs won 3-1 last season

Chicago baseball is in a serious rut. The White Sox season is depressing to watch, and they’re currently on an 11-game losing streak. The White Sox lost 6-3 at the Milwaukee Brewers Sunday despite scoring 2 runs in the top of the 1st inning. It could have been worse, as the Brewers left 6 men on base, while the White Sox left 4.

The Cubs, after a strong start to the season, have lost 8 of their last 10 games and are below .500. They fell 5-2 to the Cincinnati Reds in Chicago Sunday. They had given up 5 runs by the 3rd inning and left 9 runners on base, compared to the Reds’ 6.

White Sox at Cubs projected starters

RHP Chris Flexen vs. LHP Shota Imanaga

Flexen (2-5, 5.50 ERA) makes his 11th start and 13th appearance. He has a 1.40 WHIP, 3.7 BB/9 and 7.0 K/9 in 54 innings.

  • Last start: Loss, 5 IP, 2 ER, 4 H, 5 BB, 6 K in 3-1 home loss against Toronto Blue Jays Wednesday
  • 2024 road stats: 1-2, 4.76 ERA (22 2/3 IP, 12 ER) in 3 starts and 2 relief appearances

Imanaga (5-1, 1.86 ERA) makes his 11th start. He has a 1.00 WHIP, 1.6 BB/9 and 9.2 K/9 in 58 innings.

  • Last start: Loss, 4 1/3 IP, 7 ER, 8 H, 1 BB, 1 K in 10-6 road loss to Brewers Wednesday
  • 2024 home stats: 2-0, 1.20 ERA (30 IP, 4 ER) in 5 starts

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White Sox at Cubs odds

Provided by BetMGM Sportsbook, one of the most popular betting apps; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:25 p.m. ET.

  • Moneyline (ML): White Sox +240 (bet $100 to win $240) | Cubs -300 (bet $300 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (+120) | Cubs -1.5 (-145)
  • Over/Under (O/U): 9.5 (O: -105 | U: -115)

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White Sox at Cubs picks and predictions

Prediction

White Sox 4, Cubs 3

Moneyline

I’m not saying that the White Sox (+240) will win, but there is value in picking them as underdogs. Their inter-league record (5-12) is better than any other opponent by division; their 5-14 record against the AL East is their next best category.

But since they are also at plus money on the run line, I will PASS here.

Run line/Against the spread

The Cubs have been awful recently, and while Imanaga is their top pitcher, their bullpen will still give up runs. I like the White Sox to keep things close, or potentially win.

LEAN WHITE SOX +1.5 (+120).

Over/Under

The main source of recent troubles for both teams has been offense. The White Sox are 30th in runs per game in the past 3 weeks, while the Cubs are 29th.

Imanaga is in a perfect get-right spot after a loss. But his team’s bats may not provide much insurance.

BET UNDER 9.5 (-115).

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Chicago White Sox at Chicago Cubs odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

The Chicago White Sox (48-72) and Chicago Cubs (61-58) wrap up their 4-game season series on Wednesday night. First pitch from Wrigley Field is set for 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 2-1

The White Sox won 5-3 on Tuesday, but they’ve lost 3 of their last 4  after getting swept by the Milwaukee Brewers. They’re 5-5 in their last 10 games and sit 18 1/2 games out of a Wild-Card spot.

The Cubs are also 5-5 in their last 10 games, losing their last 2 games to the Toronto Blue Jays and White Sox. They’re 1 game out of aWild-Card spot and 3 1/2 games behind the Milwaukee Brewers for the NL Central lead.

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White Sox at Cubs projected starters

RHP Mike Clevinger vs. RHP Javier Assad

Clevinger (5-5, 3.55 ERA) makes his 16th start. He has a 1.30 WHIP, 3.4 BB/9 and 7.3 K/9 in 78 2/3 innings.

  • Last start: Win, 6 IP, 1 ER, 3 H, 3 BB, 6 K in 9-2 home victory vs. New York Yankees on Aug. 9
  • Road stats: 2-4, 4.85 ERA (42 2/3 IP, 23 ER) in 8 games (8 starts)
  • 1 career start vs. Cubs (regular-season): 0-0, 4.15 ERA (4 1/3 IP, 2 ER)

Assad (2-2, 3.12 ERA) makes his 4th start. He has a 1.27 WHIP, 3.9 BB/9 and 6.7 K/9 in 60 2/3 innings.

  • Last start: Win, 7 IP, 1 ER, 4 H, 1 BB, 2 K in 6-2 road victory vs. Toronto Blue Jays on Friday
  • Home stats: 0-2, 3.63 ERA (39 2/3 IP, 16 ER) in 14 games (2 starts)
  • Career vs. White Sox (regular-season): 1-0, 0.00 ERA (1 2/3 IP, 0 ER) in 1 relief appearance

White Sox at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:51 a.m. ET.

  • Moneyline (ML): White Sox +140 (bet $100 to win $140) | Cubs -165 (bet $165 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-130) | Cubs -1.5 (+110)
  • Over/Under (O/U): 11 (O: +100 | U: -120)

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White Sox at Cubs picks and predictions

Prediction

Cubs 6, White Sox 4

Moneyline

The Cubs are looking to bounce back from Tuesday’s 5-3 loss and are also trying to avoid losing 3 straight games for the 1st time since the All-Star break. I think they’ll do so.

Clevinger struggles on the road and hasn’t gone more than 6 innings all season, so it’ll be on the White Sox’s bullpen, which owns the 7th-highest ERA in the league. I’m just not willing to lay down a bet at -165, so PASS.

Run line/Against the spread

Of the Cubs’ last 8 wins, 6 of them have been by at least 2 runs. And before the White Sox’s win on Tuesday night, they had lost 9 of their last 13 games, so they’ve struggled as of late.

BET CUBS -1.5 (+110) to cover the run line at home.

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Over/Under

The total has gone Over in 2 of the 3 games between the Cubs and White Sox this season, but only once has the score been more than 10 runs. With the line set higher, I like the UNDER 11 (-120) Wednesday at Wrigley, even with 2 below-average starters on the mound.

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Chicago White Sox at Chicago Cubs odds, picks and predictions

Analyzing Wednesday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB expert picks and predictions.

The Chicago Cubs (10-13) host the Chicago White Sox (9-14) Wednesday in the 2-game interleague miniseries finale. First pitch at Wrigley Field is scheduled for 7:40 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Cubs odds with MLB picks and predictions.

The White Sox won the series opener 3-1 Tuesday, thanks to an awesome pitching performance as 6 Chicago pitchers struck out 12 of the 35 Cubs hitters faced.

The White Sox have won 3 of their last 4 games but are just 4 of their last 10. The Cubs are 3-7 in their last 10 games and have lost 3 consecutive series.

The White Sox beat the Cubs in 5 of 6 meetings in 2021 and had a plus-21 run differential in those games.

White Sox at Cubs projected starters

RHP Lucas Giolito vs. RHP Kyle Hendricks 

Giolitto (0-1, 2.57 ERA) lost 5-1 to the Los Angeles Angels in his last outing Friday, throwing 6 IP with 3 ER on 7 H, 2 HR, 1 BB and 7 K.

  • Career vs. the Cubs: 1-3 with an 8.71 ERA (20 2/3 IP, 20 ER), 1.84 WHIP and 9.6 K/9 in 4 starts since his 2016 rookie season.
  • vs. Cubs on the current roster: 9.43 FIP with a .299 expected batting average (xBA), .423 expected wOBA (xwOBA), .548 expected slugging percentage (xSLG), 16.7 K% and 88.1 mph exit velocity (EV) in 30 plate appearances (PA).

Hendricks (1-2, 5.47 ERA) got drubbed Friday in a 11-1 loss at the Milwaukee Brewers, surrendering 6 ER in 4 1/3 IP on 7 H, 3 HR and 2 BB with 2 K.

  • 2021 vs. the White Sox: 0-1 with an 8.44 ERA (10 2/3 IP, 10 ER), 14 H, 3 HR, 5 BB and 11 K in 2 starts.
  • vs. White Sox on the current roster: 6.38 FIP with a .307 xBA, .370 xwOBA, .515 xSLG, 13.0 K% and 86.7 mph EV in 123 PA.

White Sox at Cubs odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:06 p.m ET.

  • Money line (ML): White Sox -150 (bet $150 to win $100) | Cubs +122 (bet $100 to win $122)
  • Run line (RL)/Against the spread (ATS): White Sox -1.5 (+122) | Cubs +1.5 (-150)
  • Over/Under (O/U): 6.5 (O: -122 | U: -105)

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White Sox at Cubs picks and predictions

Prediction

Cubs 4, White Sox 3

Money line

BET the CUBS (+122). I give the Cubs a slight edge in the pitching matchup because Giolito’s pitching peripherals versus the Cubs are a lot uglier than Hendricks’ against the White Sox (-150) and the White Sox bullpen may be fatigued.

Hendricks pitches better at home with a 2.91 ERA (3.94 road ERA) and 1.08 WHIP (1.22 road WHIP). Also, the Cubs’ bullpen’s advanced pitching metrics are actually stronger than the White Sox’s and the White Sox bullpen got a lot of work in the series opener.

Furthermore, the Cubs have hit much better against right-handed pitching than the White Sox. The Cubs are ninth in wOBA (.319), 10th in wRC+ (108), according to FanGraphs. While the White Sox are last in both wOBA (.260) and wRC+ (71) and 24th in hard-hit rate (25.6%).

Lastly, the line freeze in the betting market for the game suggests the oddsmakers are begging for more White Sox money. According to Pregame.com, nearly 80% of the action is on the White Sox, but the line hasn’t moved much from the opener.

BET the CUBS (+122).

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Run line/Against the spread

PASS with a “lean” to the Cubs +1.5 (-150) since they are 5-2 RL as home underdogs so far this season.

But the Cubs’ RL price point is a little too pricey and the White Sox -1.5 (+122) are 15-6 RL in interleague games since the beginning of last season.

Over/Under

LEAN to the OVER 6.5 (-122) because both starters are struggling to start the year and don’t have good pitching peripherals versus their respective opponents Wednesday. Also, the Cubs are 4-2-1 O/U as home underdogs and White Sox are 4-2 O/U as road favorites.

However, I cannot fully get behind an Over bet because these teams have a combined 17-26-2 O/U in interleague games since the beginning of last season and the total has been lowered by a sharp line move.

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Chicago White Sox at Chicago Cubs odds, picks and prediction

Analyzing Sunday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB picks and predictions.

The Chicago White Sox (65-46) seek a road series sweep Sunday in the finale of their three-game set against the Chicago Cubs (52-60). First pitch is scheduled for 7:09 p.m. ET at Wrigley Field. Let’s analyze the lines around the White Sox vs. Cubs odds with MLB picks and predictions.

White Sox RHP Dylan Cease (8-6, 3.92 ERA) makes his 23rd start of the year. He has a 1.26 WHIP, 3.6 BB/9 and 11.7 K/9 through 114 2/3 IP.

  • Cease pitched 6 scoreless innings and struck out 11 in a 7-1 victory against Kansas City Tuesday.
  • The White Sox are 13-9 when Cease starts but only 5-6 in his road starts.

Cubs RHP Zach Davies (6-8, 4.79 ERA) makes his 24th start of the season. He has a 1.53 WHIP, 4.8 BB/9 and 6.3 K/9 through 112 2/3 IP.

  • The Cubs have lost six of Davies’ last seven starts.
  • He has allowed 11 earned runs in his last 10 innings pitched.

White Sox at Cubs odds, lines, picks and prediction

MLB odds courtesy of Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 11:40 a.m. ET.

  • Money line: White Sox -190 (bet $190 to win $100) | Cubs +155 (bet $100 to win $155)
  • Against the spread/ATS: White Sox -1.5 (-120) | Cubs +1.5 (-105)
  • Over/Under: 10.5 (O: +100 | U: -125)

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Prediction

White Sox 6, Cubs 2

Money line (ML)

The White Sox have taken the first two games of the series and are 27-26 on the road. They have won four of their last six games overall.

The Cubs are struggling. They are 2-9 in their last 11 games. They are 31-23 at home but have dropped their last five games at Wrigley Field.

Take the WHITE SOX (-190).

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Run line/Against the spread (ATS)

The White Sox are 58-53 ATS overall,  but when they win they do it by more than one run. 18 of their last 20 victories have been by 2 or more runs.

Conversely, the Cubs often lose by multiple runs. Seven of their last 10 losses have been by 2 or more runs. They are 61-51 ATS overall.

Take the WHITE SOX -1.5 (-120).

Over/Under (O/U)

49% of the games at Wrigley Field have gone Over the projected total.

The White Sox have only had two of their last 16 games finish with totals of more than 10 runs.

Half of the Cubs’ last 10 games have finished with 11 or more runs.

Take UNDER 10.5 (-125).

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