The Chicago Cubs host the Milwaukee Brewers on Opening Day Thursday at Wrigley Field with the first pitch scheduled for 2:20 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Brewers vs. Cubs odds with MLB picks and predictions.
Season series: The Brewers won last season’s series with the Cubs 15-4, including an 8-2 record in Chicago, and outscored the Cubs 124-67.
Milwaukee won the National League Central with a 95-67 record, but was eliminated in the NLDS 3-1 by the eventual champion Atlanta Braves.
Chicago finished fourth with a 71-91 record after winning the NL Central in 3 of the previous 5 seasons, which included a 2016 World Series victory.
Brewers at Cubs: Projected starters
RHP Corbin Burnes vs. RHP Kyle Hendricks
Burnes won the 2021 NL Cy Young, finishing 11-5 in just 167.0 IP, but he led the majors in ERA (2.43) and K/9 (12.6).
- 2021 vs. Cubs: 2-0 with a 1.35 ERA (20.0 IP, 3 ER), 9 H, 36 K and 3 BB in 3 starts.
- vs. Cubs on the current roster: 2.87 FIP with .220 batting average (BA), .291 wOBA, .385 expected slugging percentage (xSLG), 39.4 K% and 92.9 mph exit velocity (EV) in 66 plate appearances (PA).
Hendricks is Chicago’s Opening Day starter for the third time. He was 14-7 last season in 181.0 IP, but with a career-worst ERA (4.77) and WHIP (1.35).
- 2021 vs. Brewers: 1-1 with a 6.14 ERA (22.0 IP, 15 ER), 28 H, 19 K and 5 BB in 4 starts.
- vs. Brewers on the current roster: 3.23 FIP with a .242 BA, .291 wOBA, .369 xSLG, 23.3 K% and 85.7 mph EV in 253 PA.
Brewers at Cubs odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:32 a.m. ET.
- Money line (ML): Brewers -175 (bet $175 to win $100) | Cubs +140 (bet $100 to win $140)
- Run line (RL)/Against the spread (ATS): Brewers -1.5 (-110) | Cubs +1.5 (+110)
- Over/Under (O/U): 10.5 (O: +100 | U: -125)
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Brewers at Cubs prediction and picks
Prediction
Brewers 7, Cubs 2
Money line
BET the BREWERS (-175) for 1 unit because they beat the Cubs (+140) in 9 of their final 10 meetings last season and Chicago didn’t make any notable upgrades this offseason.
Furthermore, Burnes was dominant versus the Cubs in 2021 and the Brewers have won 7 consecutive games as road favorites with Burnes on the mound.
Also, Chicago was terrible against right-handed pitching last season, ranking 23rd in wRC+, 19th in wOBA and last in BB/K versus righties.
Lastly, even if Hendricks gives the Cubs a quality outing, Milwaukee’s lineup can certainly rally back against this awful Chicago bullpen. Cubs relievers were 28th in WAR, 22nd in xFIP and 25th in home runs allowed per 9 innings as a platoon.
The BREWERS (-175) are expensive, but are the right side because they have a decisive edge over the Cubs (+140).
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Run line/Against the spread
LEAN BREWERS -1.5 (-110) since they had the fourth-best ATS record in division games last season at 45-31 RL and the Cubs +1.5 (-110) were just 35-41 RL against NL Central foes.
However, I’d prefer to stick with Milwaukee’s ML since the strength of the Brewers is their pitching and their lineup significantly underperformed in 2021.
Over/Under
LEAN UNDER 10.5 (-125) because I’m expecting a bounce-back season from an otherwise solid Hendricks and Burnes has some of the best stuff in baseball.
That said, this total is high and it feels like the oddsmakers are begging for Under 10.5 (+100) money. My biggest concern with an UNDER 10.5 (-125) is the weather forecast that predicts 20-plus mph winds blowing out to center field.
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