The Los Angeles Chargers (8-6) and the Indianapolis Colts (4-9-1) meet on Monday Night Football in Week 16. Kickoff from Lucas Oil Stadium is sct for 8:15 p.m. (ESPN). Below, we analyze Tipico Sportsbook’s lines around the Chargers vs. Colts odds, and make our expert NFL picks and predictions.
The Chargers are alive and well in the AFC playoff picture after scoring big wins over the Miami Dolphins and Tennessee Titans in the last 2 weekends to strengthen their postseason chances.
The Colts are eliminated from the playoffs, and Indianapolis is coming off a historic 2nd-half collapse in Minnesota last week. The Colts were up 33-0 at half, but blew that lead and lost 39-36 in overtime.
It wasn’t QB Matt Ryan‘s fault the team struggled defensively in the second half last week, but interim coach Jeff Saturday is making the change to Nick Foles this week.
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Chargers at Colts odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 6:12 p.m. ET.
- Moneyline (ML): Chargers -210 (bet $210 to win $100) | Colts +180 (bet $100 to win $180)
- Against the spread: Chargers -4 (-112) | Colts +4 (-108)
- Over/Under (O/U): 45.5 (O: -108 | U: -112)
Chargers at Colts key injuries
Chargers
- CB Bryce Callahan (groin) questionable
- S Derwin James Jr. (quadriceps) questionable
- DL Sebastian Joseph-Day (knee, back) questionable
- OT Trey Pipkins III (knee) questionable
- LB Chris Rumph II (quadriceps) questionable
Colts
- CB Brandon Facyson (illness) questionable
- TE Kylen Granson (ankle) questionable
- CB Kenny Moore II (ankle) questionable
- WR Mike Strachan (concussion) questionable
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Chargers at Colts picks and predictions
Prediction
Chargers 29, Colts 16
Moneyline
The Chargers will cost you over 2 times your potential return, and that’s just a little too expensive, even against a struggling Colts team with nothing to play for.
AVOID, and look to the line instead.
Against the spread
Look to the CHARGERS -4 (-112) to cover on the road in this ultra-important game for them.
While L.A. is just 1-3-1 ATS in its last 5 games in December, including a 1-1-1 ATS mark this season, it is 5-2 ATS in the last 7 road games, and 5-2 ATS in the last 7 following a non-cover, too.
The Colts are likely emotionally checked out after yet another quarterback change, the huge collapse last week, and elimination from the playoffs.
Over/Under
UNDER 45.5 (-112) is the mostly dominant trend for both teams, and it is the lean, ever so slightly.
The Under is 5-2 in the last 7 games for the Chargers, while cashing at a 7-2 clip in the last 9 appearances on MNF.
While the Colts had a high-scoring game last Saturday in Minnesota, the Under is 6-2 in the last 8 games at home, while cashing in 6 of the last 8 against winning teams, too. The Under is also 4-0 in the last 4 at home against teams with a winning home record.
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