Carolina Panthers vs. Buffalo Bills odds predictions pick betting line spread

Carolina Panthers at Buffalo Bills odds, picks and predictions

Analyzing Saturday’s Carolina Panthers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

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The Buffalo Bills (1-1) welcome the Carolina Panthers (0-2) to Highmark Stadium Saturday for the final week of preseason. Kickoff is set for 1 p.m. ET. Below, we analyze FanDuel Sportsbook’s lines around the Panthers vs. Bills odds, and make our expert NFL picks and predictions.

The Bills lost to the Chicago Bears 33-6 in Week 1 of the preseason, failing to cover as 3-point home favorites. They did bounce back and beat the Pittsburgh Steelers 9-3 on the road Saturday, closing as 2.5-point underdogs. Buffalo is 1-1 against the spread (ATS) and 1-1 O/U. QB Josh Allen has only played 1 drive, completing 2 of 3 passes for 22 yards.

The Panthers have lost both preseason games, dropping the first battle 17-3 to the New England Patriots on the road and the second one 15-12 to the visiting New York Jets. Carolina failed to cover in both, closing as a 6.5-point underdog in the opener and a 1.5-point favorite Aug. 17. QB Bryce Young has yet to attempt a pass in the preseason, so he might see a drive Saturday.

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Panthers at Bills odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:59 a.m. ET.

Moneyline (ML): Panthers -230 (bet $230 to win $100) | Bills +190 (bet $100 to win $190)
Against the spread: Panthers -4.5 (-115) | Bills +4.5 (-105)
Over/Under (O/U): 31.5 (O: -105 | U: -115)

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Panthers at Bills picks and predictions

Prediction

Panthers 17, Bills 13

Moneyline

PASS.

There’s not much value here. The Panthers (-230) haven’t shown enough to be heavy favorites, and paying more than twice your potential return in a preseason game is far too risky.

Against the spread

BET BILLS +4.5 (-105).

The home underdog is the best play here. The Bills are coming off a win in which their defense allowed just 3 points to the Steelers. While they did allow 33 the first week, 20 of those were in the 4th quarter, so their defense held strong for most of the game.

The Panthers haven’t got much of anything going in the preseason, scoring a combined 15 points while allowing 32. They have lost both and failed to cover both. With that in mind, take the underdog here, and back BILLS +4.5 (-105).

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Over/Under

BET UNDER 31.5 (-115).

The Panthers are 0-2 O/U, having scored 12 or fewer points in both games. They likely won’t play Young much, and outside of him, their skill players lack the ability to create that offensive magic. They totaled 156 total yards against the Jets.

The Bills have yet to score double digits as well and only went Over when they allowed 33 points to Chicago in Week 1. Considering those trends for both sides and in the preseason in general, back UNDER 31.5 (-115).

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Carolina Panthers at Buffalo Bills odds, picks and prediction

Analyzing Sunday’s Carolina Panthers at Buffalo Bills odds and lines, with expert NFL picks, predictions and best bets.

The Carolina Panthers (5-8) travel to face the Buffalo Bills (7-6) in a Week 15 matchup Sunday. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Panthers vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

The Panthers are skidding, dropping three in a row while failing to cover each. The defense has been an issue, allowing 27 or more points in each of the losses, and the Over has hit in four consecutive games for Carolina.

The Bills dropped a 33-27 overtime heartbreaker at Tampa Bay last week, which was like losing twice. The Bills erased a late 27-10 deficit to force overtime, but couldn’t stop the Bucs in OT. Buffalo enters on a 2-5-1 ATS slide.

Panthers at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 2:25 p.m. ET.

Money line: Panthers +470 (bet $100 to win $470) | Bills -700 (bet $700 to win $100)
Against the spread (ATS): Panthers +10.5 (-105) | Bills -10.5 (-115)
Over/Under (O/U): 44.5 (O: -105 | U: -115)

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Panthers at Bills key injuries

Panthers

CB A.J. Bouye (foot) out
WR DJ Moore (hamstring) questionable
OG Michael Jordan (hamstring) questionable
OG John Miller (ankle) questionable

Bills

WR Emmanuel Sanders (knee) doubtful
DT Star Lotulelei (toe) questionable

Panthers at Bills odds, lines, predictions and picks

Prediction

Bills 29, Panthers 13

Money line

The Bills (-700) are going to snap back on track with a win over head coach Sean McDermott’s old team, but you can’t lay seven times your potential winnings on a team that is just one game over .500. Don’t do it.

PASS.

Against the spread

The BILLS -10.5 (-115) are 2-1-1 ATS as a double-digit favorite this season, and they’re 2-1 SU/ATS against three NFC opponents.

Buffalo is 6-1-1 ATS in the past eight against teams with a losing record, so expect the Bills to finally pull it together and put a performance together worthy of a playoff team.

Over/Under

The UNDER 44.5 (-115) hit in Buffalo’s most recent home game, but blustering, wintry conditions played a huge part in its 14-10 loss to New England on Monday night in Week 13.

The temperature will be around freezing with winds of 13-16 mph, but not too terribly for this time of year in western New York.

The Under is 5-2 in the past seven at home for the Bills and 4-1 in the past five against teams with a losing record. The Panthers’ offense has been mediocre, and the Bills’ D should shut them down for a convincing win.

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First look: Carolina Panthers at Buffalo Bills odds and lines

Looking at Sunday’s Carolina Panthers at Buffalo Bills Week 15 NFL odds, lines and trends. Here’s what you need to know.

The Carolina Panthers (5-8) and Buffalo Bills (7-6) meet in a Week 15 game Sunday at Highmark Stadium in Orchard Park, N.Y. Below, we look at the Panthers vs. Bills odds and lines; check back for our NFL picks and predictions.

The Panthers were on the short end of a 29-21 home loss to the Atlanta Falcons, losing for the third consecutive time since winning at Arizona in Week 10. Carolina is 0-3 SU/ATS across the past three, while hitting the Over in four straight outings.

The Bills nearly pulled off a huge comeback at the Tampa Bay Buccaneers in Week 14, falling 33-27 in overtime. Buffalo has lost back-to-back games for the first time this season, and has failed to cover in consecutive games for the first time, too.

Also see: All Week 15 odds and lines

Panthers at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 3:23 a.m. ET.

Money line: Panthers +420 (bet $100 to win $420) | Bills -600 (bet $600 to win $100)
Against the spread (ATS): Panthers +10.5, -115 (bet $115 to win $100) | Bills -10.5, -105 (bet $105 to win $100)
Over/Under (O/U): 43.5, O: -108 (bet $108 to win $100) | U: -112 (bet $112 to win $100)

Also see: Betting 101

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2021 betting stats:

ML: Panthers 5-8 | Bills 7-6
ATS: Panthers 5-8 | Bills 6-6-1
O/U: Panthers 6-7 | Bills 6-7

Panthers at Bills head-to-head

The last time these teams faced each other, Carolina scratched out a 9-3 win at Bank of America Stadium Sept. 17, 2017. The last time they met in Buffalo was Sept. 15, 2013 with the Bills squeaking out a 24-23 victory.

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