First look: San Francisco 49ers at Carolina Panthers odds and lines

Looking at Sunday’s San Francisco 49ers vs. Carolina Panthers Week 5 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers (2-2) travel to meet the Carolina Panthers (1-3) Sunday at Bank of America Stadium. Kickoff from Charlotte is scheduled for 4:05 p.m. ET (CBS). Below, we look at 49ers vs. Panthers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The 49ers roughed up the defending champs, winning 24-9 against the visiting Los Angeles Rams Monday night behind a strong defensive effort. San Francisco’s defense recorded 7 sacks and posted a pick-6 by 2nd-year DB Talanoa Hufanga.

The Panthers were on the short end of a 26-16 setback at home against the Arizona Cardinals in Week 4, falling to 1-2 straight up and against the spread (SU/ATS) in 3 home games. QB Baker Mayfield is on the hot seat after an ice-cold start with his new team, posting just 4 TD passes and 1 TD run across the first 4 outings.

Also seeAll Week 5 odds and lines

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49ers at Panthers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 5:30 a.m. ET.

  • Moneyline (ML): 49ers -250 (bet $250 to win $100) | Panthers +205 (bet $100 to win $205)
  • Against the spread (ATS): 49ers -5.5 (-112) | Panthers +5.5 (-108)
  • Over/Under (O/U): 39.5 (O: -110 | U: -110)

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2022 betting stats

  • ML: 49ers 2-2 | Panthers 1-3
  • ATS: 49ers 2-2 | Panthers 1-3
  • O/U: 49ers 0-4 | Panthers 1-3

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49ers at Panthers head-to-head

This is the first meeting since Oct. 27, 2019, a 51-13 rout by the 49ers at Levi’s Stadium in Santa Clara. Carolina won the past 2 meetings before that, including a 46-27 win Sept. 18, 2016, the most recent meeting in Charlotte. The Under has edged the Over 3-2 in the past 5 in the series, and the Panthers are 5-2 ATS across the past 7 meetings dating back to Dec. 2, 2007.

Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

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First look: Arizona Cardinals at Carolina Panthers odds and lines

Looking at Sunday’s Arizona Cardinals at Carolina Panthers Week 4 NFL odds, lines and trends. Here’s what you need to know.

The Arizona Cardinals (1-2) are on the road in Week 4 to take on the Carolina Panthers (1-2) Sunday. Kickoff is set for 4:05 p.m. ET at Bank of America Stadium (FOX). Below, we look at Cardinals vs. Panthers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Cardinals suffered a 20-12 home loss to the Los Angeles Rams in Week 3. They have lost 6 straight games at State Farm Stadium. Arizona fell behind 13-0 and never scored a touchdown despite outgaining Los Angeles (365-339). It was the 11th time the Cards lost to the Rams in their last 12 matchups.

The Panthers picked up their first win of the year Sunday with a 22-14 home victory over the New Orleans Saints. They had a season-high 293 yards of offense and the defense forced 3 turnovers and scored a fumble-recovery touchdown. RB Christian McCaffrey had 108 rushing yards and QB Baker Mayfield had a touchdown pass in the win.

Also seeAll Week 4 odds and lines

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Cardinals at Panthers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:40 a.m. ET.

  • Money line (ML): Cardinals -101 (bet $101 to win $100) | Panthers -117 (bet $117 to win $100)
  • Against the spread (ATS): Cardinals +1.5 (-112) | Panthers -1.5 (-108)
  • Over/Under (O/U): 44.5 (O: -105 | U: -115)

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2022 betting stats

  • ML: Cardinals 1-2 | Panthers 1-2
  • ATS: Cardinals 1-2 | Panthers 1-2
  • O/U: Cardinals 2-1 | Panthers 1-2

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Cardinals vs. Panthers head-to-head

Including 3 postseason matchups, this will be the 20th time the two teams have played. The Panthers have dominated this series 14-5 and have won the last 6 meetings, including twice in the playoffs.

The Cardinals have not beaten the Panthers since 2013; Carolina won last season’s meeting in a 34-10 blowout. New Panthers QB Baker Mayfield is 0-2 against the Cardinals in his career.

Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

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First look: New Orleans Saints at Carolina Panthers odds and lines

Looking at Sunday’s New Orleans Saints at Carolina Panthers Week 3 NFL odds, lines and trends. Here’s what you need to know.

The New Orleans Saints (1-1) and the Carolina Panthers (0-2) meet Sunday in Week 3 NFL action. Kickoff from Bank of America Stadium in Charlotte is scheduled for 1 p.m. ET (FOX). Below, we look at Saints at Panthers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Saints had a rousing 27-26 comeback win at the Atlanta Falcons to open the season, before losing 20-10 at home to the Tampa Bay Buccaneers in Week 2 in a defensive battle. New Orleans now plays a divisional opponent for a 3rd straight outing.

The Panthers lost in a 1-score game for the second consecutive weekend, and they’re now 2-14 ATS across their last 16 games overall. Coach Matt Rhule’s team is also 0-4 ATS in the previous 4 games inside the division and 6-19-1 ATS in the past 26 at home.

Also see: All Week 3 odds and lines

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Saints at Panthers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:30 a.m. ET.

  • Money line (ML): Saints -155 (bet $155 to win $100) | Panthers +130 (bet $100 to win $130)
  • Against the spread (ATS): Saints -3.5 (+110) | Panthers -3.5 (-135)
  • Over/Under (O/U): 40.5 (O: -110 | U: -110)

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2022 betting stats

  • ML: Saints 1-1 | Panthers 0-2
  • ATS: Saints 0-2 | Panthers 0-2
  • O/U: Saints 1-1 | Panthers 1-1

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Saints at Panthers head-to-head

These teams split the regular-season series in 2021, while the home team has won 3 of the past 4 meetings overall. Carolina holds a slight 6-3 ATS edge across the previous 9 meetings, while the Under has cashed in 3 straight in this series.

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First look: Carolina Panthers at New York Giants odds and lines

Looking at Sunday’s Carolina Panthers at New York Giants Week 2 NFL odds, lines and trends. Here’s what you need to know.

The Carolina Panthers (0-1) and New York Giants (1-0) meet for a Week 2 matchup at MetLife Stadium Sunday. Kickoff is scheduled for 1 p.m. ET (FOX). Below, we look at Panthers at Giants odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Panthers had a seesaw battle against the Cleveland Browns in Week 1. QB Baker Mayfield rallied his team back from a 13-point deficit to take a late 24-23 lead, but Carolina fell with a 58-yard field from Browns PK Cade York with 8 seconds remaining in regulation for the difficult opening-game loss.

The Giants trailed 20-13 on the road in the 4th quarter against the Tennessee Titans. New York saw RB Saquon Barkley, finally healthy, exploded for a big game. The Giants scored late, and coach Brian Daboll elected to go for a 2-point conversion, rather than play for OT. New York converted and hung on for the 21-20 win as Titans PK Randy Bullock missed a 47-yard field goal attempt at the buzzer.

Also seeAll Week 2 odds and lines

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Panthers at Giants odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 6:03 a.m. ET.

  • Money line (ML): Panthers +115 (bet $100 to win $115) | Giants -135 (bet $135 to win $100)
  • Against the spread (ATS): Panthers +2.5 (-105) | Giants -2.5 (-115)
  • Over/Under (O/U): 42.5 (O: -117 | U: -103)

[the_huddle]

2022 betting stats

  • ML: Panthers 0-1 | Giants 1-0
  • ATS: Panthers 0-1 | Giants 1-0
  • O/U: Panthers 1-0 | Giants 0-1

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Panthers vs. Giants head-to-head

These teams met last season in the Meadowlands, and the G-Men picked up an impressive 25-3 victory. It was New York’s only win in the last 4 meetings dating back to Sept. 2013. New York is 5-1 ATS in the last 6 meetings and 8-2 ATS in the past 10 meetings dating back to Dec. 2006.

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First look: Cleveland Browns at Carolina Panthers odds and lines

Looking at Sunday’s Cleveland Browns at Carolina Panthers Week 1 NFL odds, lines and trends. Here’s what you need to know.

The Cleveland Browns and Carolina Panthers open the season against each other in Week 1 of the 2022 NFL season. Kickoff on Sunday,. Sept. 11,  is at 1 p.m. ET (CBS) at Bank of America Stadium. Below, we analyze Tipico Sportsbook‘s lines around the Browns vs. Panthers odds and lines; check back for our NFL picks and predictions.

Both teams have new starting quarterbacks. The Browns traded for QB Deshaun Watson, but he was suspended for the first 11 games of the season under the league’s personal conduct policy, which means they turn to QB Jacoby Brissett. Cleveland missed the playoffs last season going 8-9.

A familiar face will lead the Panthers as the Browns traded former No. 1 overall pick Baker Mayfield to Carolina, where he was named the starting quarterback. The Panthers finished in last place in the NFC South last season at 5-12.

Also see: All Week 1 odds and lines

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Browns at Panthers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday, Aug. 29, at 12:01 a.m. ET.

  • Money line (ML): Browns +110 (bet $100 to win $110) | Panthers -135 (bet $135 to win $100)
  • Against the spread (ATS): Browns +2.5 (-105) | Panthers -2.5 (-115)
  • Over/Under (O/U): 41.5 (O: -108 | U: -112)

[the_huddle]

2021 betting stats:

  • ML: Browns 8-9 | Panthers 5-12
  • ATS: Browns 7-10 | Panthers 5-12
  • O/U: Browns 7-10 | Panthers 8-9

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Browns at Panthers head-to-head

The teams have only faced each other 6 times, the first time in 1999. The Panthers lead the all-time series 4-2, although the Browns have won 2 of the last 3 matchups.

The Browns won their last matchup in 2018, beating the Panthers 26-20.

The Panthers have won both games played in Carolina.

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First look: Carolina Panthers at Tampa Bay Buccaneers odds and lines

Looking at Sunday’s Carolina Panthers at Tampa Bay Buccaneers Week 18 NFL odds, lines and trends. Here’s what you need to know.

The Carolina Panthers (5-11) visit the Tampa Bay Buccaneers (12-4) for a Week 18 battle Sunday in Tampa. The contest at Raymond James Stadium is slated for a 4:25 p.m. ET kickoff. Below, we look at the Panthers vs. Buccaneers odds and lines; check back for our NFL picks and predictions.

Carolina lost its sixth consecutive game Sunday at New Orleans, falling 18-10. The Panthers led 10-3 early but did not score after the 13:09 mark of the second quarter. The Saints held a sluggish Panthers offense to just 178 total yards. The Panthers head into this game ranked 30th in total offense (297.8 total yards per game).

The Buccaneers squeaked by with a 28-24 win over the New York Jets Sunday. QB Tom Brady connected with WR Cyril Grayson on a go-ahead touchdown with 15 seconds left in the game. Brady directed the NFL’s top passing attack (306.6 yards per game) to 405 yards. The victory marked the Bucs’ sixth in their last seven games.

Also see: All Week 18 odds and lines

Panthers at Buccaneers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1 p.m. ET.

  • Money line: Panthers +310 (bet $100 to win $310) | Buccaneers -410 (bet $410 to win $100)
  • Against the spread (ATS): Panthers +7.5, -108 (bet $108 to win $100) | Buccaneers -7.5, -112 (bet $112 to win $100)
  • Over/Under (O/U): 42.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Panthers 5-11 | Buccaneers 12-4
  • ATS: Panthers 5-11 | Buccaneers 8-8
  • O/U: Panthers 7-9 | Buccaneers 8-8

Panthers at Buccaneers head-to-head

In a series that dates back to 1995, Carolina leads Tampa Bay 24-18. Against the spread, the Panthers are 1-5 in their last six meetings with the Buccaneers, but they are 6-2 ATS in their last eight games at Tampa Bay.

Tampa Bay downed Carolina 32-6 in Week 16, and the Bucs have won five of their last six in the series.

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First look: Carolina Panthers at New Orleans Saints odds and lines

Looking at Sunday’s Carolina Panthers at New Orleans Saints Week 17 NFL odds, lines and trends. Here’s what you need to know.

The Carolina Panthers (5-10) visit the New Orleans Saints (7-8) for a Week 17 matchup Sunday. Kickoff from Caesars Superdome is scheduled for 4:25 p.m. ET. Below, we look at the Panthers vs. Saints odds and lines; check back for our NFL picks and predictions.

The Panthers were smashed 32-6 at home by the Tampa Bay Buccaneers as 11.5-point underdogs as the Under (43.5) connected. Carolina is 0-5 straight up and against the spread in its past five games since a Week 10 win at Arizona. The Over is 5-1 across the past six contests.

Also see: All Week 17 odds and lines

The Saints lost 20-3 to at home to the Miami Dolphins Monday night. New Orleans was forced to roll with third-string QB Ian Book for his first NFL start, as QBs Taysom Hill and Trevor Siemian were unavailable due to a COVID-19 outbreak among the team.

Panthers at Saints odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 2:16 a.m. ET.

  • Money line: Panthers +260 (bet $100 to win $260) | Saints -340 (bet $340 to win $100)
  • Against the spread (ATS): Panthers +6.5, -105 (bet $105 to win $100) | Washington -6.5, -115 (bet $115 to win $100)
  • Over/Under (O/U): 38.5, O: -105 (bet $105 to win $100) | U: -115 (bet $115 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Panthers 5-10 | Saints 7-8
  • ATS: Panthers 5-10 | Saints 7-8
  • O/U: Panthers 7-8 | Saints 6-9

Panthers at Saints head-to-head

These teams met in Week 2 in Charlotte with the Panthers coming away with a 26-7 win as 3-point underdogs as the Under (45) cashed.

New Orleans has won four of the past five meetings, although the Panthers are 6-2 ATS across the past eight meetings. The Over is 4-2 in the previous six, but the Under hit in the past two matchups.

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First look: Tampa Bay Buccaneers at Carolina Panthers odds and lines

Looking at Sunday’s Tampa Bay Buccaneers at Carolina Panthers Week 16 NFL odds, lines and trends. Here’s what you need to know.

The Tampa Bay Buccaneers (10-4) visit the Carolina Panthers (5-9) for a Week 16 game at Bank of America Stadium in Charlotte. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Buccaneers vs. Panthers odds and lines; check back for our NFL picks and predictions.

The Buccaneers were stunned 9-0 at home on Sunday Night Football by the New Orleans Saints. It’s the first time QB Tom Brady has lost a game as an NFL starter with the opposing team failing to score a touchdown.

The Panthers were dropped 31-14 on the road at the Buffalo Bills in Week 15, falling and failing to cover for the fourth consecutive game. The Over has cashed in five straight for Carolina, too.

Also see: All Week 16 odds and lines

Buccaneers at Panthers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 6:50 a.m. ET.

  • Money line: Buccaneers -650 (bet $650 to win $100) | Panthers +440 (bet $100 to win $440)
  • Against the spread (ATS): Buccaneers -10.5, -110 (bet $110 to win $100) | Panthers +10.5, -110 (bet $110 to win $100)
  • Over/Under (O/U): 44.5, O: -105 (bet $105 to win $100) | U: -115 (bet $115 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Buccaneers 10-4 | Panthers 5-9
  • ATS: Buccaneers 7-7 | Panthers 5-9
  • O/U: Buccaneers 7-7 | Panthers 7-7

Buccaneers at Panthers head-to-head

Brady and the Buccaneers swept the Panthers last season, with Tampa Bay winning 46-23 in Charlotte Nov. 15, 2020 as a 6-point favorite.

The Over has cashed in three straight meetings, and the favorite has also cashed in each of the past three in the series.

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First look: Carolina Panthers at Buffalo Bills odds and lines

Looking at Sunday’s Carolina Panthers at Buffalo Bills Week 15 NFL odds, lines and trends. Here’s what you need to know.

The Carolina Panthers (5-8) and Buffalo Bills (7-6) meet in a Week 15 game Sunday at Highmark Stadium in Orchard Park, N.Y. Below, we look at the Panthers vs. Bills odds and lines; check back for our NFL picks and predictions.

The Panthers were on the short end of a 29-21 home loss to the Atlanta Falcons, losing for the third consecutive time since winning at Arizona in Week 10. Carolina is 0-3 SU/ATS across the past three, while hitting the Over in four straight outings.

The Bills nearly pulled off a huge comeback at the Tampa Bay Buccaneers in Week 14, falling 33-27 in overtime. Buffalo has lost back-to-back games for the first time this season, and has failed to cover in consecutive games for the first time, too.

Also see: All Week 15 odds and lines

Panthers at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 3:23 a.m. ET.

  • Money line: Panthers +420 (bet $100 to win $420) | Bills -600 (bet $600 to win $100)
  • Against the spread (ATS): Panthers +10.5, -115 (bet $115 to win $100) | Bills -10.5, -105 (bet $105 to win $100)
  • Over/Under (O/U): 43.5, O: -108 (bet $108 to win $100) | U: -112 (bet $112 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

  • ML: Panthers 5-8 | Bills 7-6
  • ATS: Panthers 5-8 | Bills 6-6-1
  • O/U: Panthers 6-7 | Bills 6-7

Panthers at Bills head-to-head

The last time these teams faced each other, Carolina scratched out a 9-3 win at Bank of America Stadium Sept. 17, 2017. The last time they met in Buffalo was Sept. 15, 2013 with the Bills squeaking out a 24-23 victory.

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First look: Atlanta Falcons at Carolina Panthers odds and lines

Looking at Sunday’s Atlanta Falcons at Carolina Panthers Week 14 NFL odds, lines and trends. Here’s what you need to know.

The Carolina Panthers (5-7) will try to snap their two-game losing streak in Week 14 when they host their division rivals, the Atlanta Falcons (5-7). Kickoff Sunday afternoon will be at 1 p.m. ET from Bank of America Stadium in Charlotte. Below, we look at the Falcons vs. Panthers odds and lines; check back for our NFL picks and predictions.

The Falcons are just 1-3 in their last four games, losing to the Dallas Cowboys, New England Patriots and Tampa Bay Buccaneers. Their win came against the Jacksonville Jaguars, beating them by just seven points on the road. The Falcons now rank 27th in scoring and have allowed the second-most points in the NFL, so they haven’t been playing well on either side of the ball.

The Panthers were off in Week 13 for their bye, which came at a perfect time after they lost to Washington and Miami in consecutive weeks. QB Cam Newton has provided a spark since becoming the starter, but the offense is still hardly impressive with just 31 total points in the last two games. Despite allowing 60 points to Washington and Miami, the Panthers are still seventh in points allowed and second in total defense.

Falcons at Panthers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 5:10 p.m. ET.

  • Money line: Falcons +125 (bet $100 to win $125) | Panthers -155 (bet $155 to win $100)
  • Against the spread (ATS): Falcons +2.5, +105 (bet $100 to win $105) | Panthers -2.5, -130 (bet $130 to win $100)
  • Over/Under (O/U): 43.5, O: -103 (bet $103 to win $100) | U: -117 (bet $117 to win $100)

Also see: Betting 101

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2021 betting stats:

  • ML: Falcons 5-7 | Panthers 5-7
  • ATS: Falcons 5-7 | Panthers 5-7
  • O/U: Falcons 5-7 | Panthers 5-7

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Falcons at Panthers head-to-head

The Falcons and Panthers have squared off 53 times before, including once already this season. The Falcons lead the all-time series 33-20, but they’ve lost two of the last three meetings.

Since 2015, the Falcons are 9-4 against the Panthers. In their last 10 matchups, they’re 7-3 ATS, too, while the total has only gone Over three times.

The Panthers offense has struggled in recent matchups with Atlanta, only averaging 16 points per game in their last 10 games.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow @camdasilva on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | WashingtonFootballWire | DraftWire | TouchdownWire | TheListWire

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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