Cardinals Titans odds picks prediction spread over/under betting line

The Arizona Cardinals and Tennessee Titans face each other in Week 1 to kick off their 2021 NFL season. Kickoff is at 1 p.m. ET at Nissan Stadium in Nashville. Below, we look at the Cardinals at Titans prop bet odds and lines, and make our best NFL picks, predictions and bets.

The game features two teams with explosive offenses and two of the best receivers in the game right now. The Cardinals have DeAndre Hopkins and the Titans traded for Julio Jones in the offseason.

The Titans have the league’s rushing champion from the last two seasons in Derrick Henry, while the Cardinals have one of the most dynamic young quarterbacks in the league in Kyler Murray. This game appears to be a lock for lots of offensive numbers.

Also see: Week 1 best bets

Cardinals at Titans prop bet picks and predictions

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 10:40 a.m. ET.

Cardinals WR DeAndre Hopkins OVER 7.5 receptions (+115)

Hopkins had 7 or more receptions in 10 of his 16 games last season, including each of his first four games and actually set a career-high with 14 catches in his Cardinals debut. He is the No. 1 receiver for a reason and will be utilized a lot.

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Cardinals QB Kyler Murray OVER 1.5 passing TDs (-143)

Murray had multiple touchdown passes in eight games last season and the Titans allowed 36 touchdown passes to finish 31st in the NFL.

Titans RB Derrick Henry OVER 1.5 receptions (+115)

Henry had multiple receptions in seven games last season, including three in their season opener. The Cardinals had an opposing running back catch multiple passes in 10 games.

Also see: Cardinals-Titans picks and predictions

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Cardinals RB Chase Edmonds OVER 23.5 receiving yards (-114)

Edmonds had five such games last season in a complementary role. He now is the Cardinals’ top running back and will figure heavily into their offense, especially in the passing game.

Titans WR Julio Jones OVER 62.5 receiving yards (-114)

Jones has averaged 95.5 receiving yards per game over his career. The Cardinals no longer have an elite shut-down cornerback on the team and will rely on CBs Byron Murphy, Robert Alford and rookie Marco Wilson.

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The Arizona Cardinals begin their season on the road against the defending AFC South champion Tennessee Titans in Week 1. Kickoff for the season opener is at 1 p.m. ET at Nissan Stadium. Below, we look at the Cardinals vs. Titans odds and lines, and make our best NFL picks, predictions and bets.

Arizona finished 8-8 last season and missed the playoffs by one game. They improved on offense this offseason by trading for C Rodney Hudson, and signing WR A.J. Green and RB James Conner.

Arizona added DE J.J. Watt on defense and get LB Chandler Jones back from injury.

The Titans won the AFC South in 2020 at 11-5 before losing to the Baltimore Ravens in the first round of the playoffs. QB Ryan Tannehill had 40 combined passing and rushing touchdowns, while RB Derrick Henry led the NFL in rushing attempts, rushing yards and rushing touchdowns for the second straight year.

The Titans added WR Julio Jones on offense and former Steelers pass rusher Bud Dupree to bolster a pass rush that had the third-fewest sacks in 2020.

Also see: 2021 NFL team win totals

Cardinals at Titans odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 8:40 a.m. ET.

Money line: Cardinals +125 (bet $100 to win $125) | Titans -155 (bet $155 to win $100)
Against the spread (ATS): Cardinals +2.5 (+105) | Titans -2.5 (-130)
Over/Under (O/U): 52.5 (O: -108 | U: -112)

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Cardinals at Titans key injuries

Cardinals

LB Dennis Gardeck (knee) limited practice

Titans

CB Chris Jackson (hamstring) limited practice
WR Josh Reynolds (foot) limited practice

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Cardinals at Titans odds, lines, predictions and picks

Prediction

Cardinals 37, Titans 31

Money line

The Cardinals started hot in 2020 by winning on the road against the San Francisco 49ers as underdogs. They finished 4-4 on the road but won three of their first four games as visitors.

The Titans also started hot by winning their first five games. They were 5-3 at home and 3-1 against the NFC.

Both teams will score points but the Titans had an awful defense in 2020 and aren’t expected to be much better. The Cardinals defense only needs to get a couple of stops to pull off the upset.

I LEAN CARDINALS (+125).

Against the spread

Neither team ended last season performing well against the spread. Arizona finished 7-9 ATS while the Titans were 7-10 ATS, including their playoff loss.

The Cardinals, though, covered the spread in their first two games of the season and in five of their first seven contests.

Tennessee started slow against the spread and failed to cover in each of their first three games.

With the lean to the Cardinals with the money line, I also LEAN CARDINALS +2.5 (+105) for some insurance.

Over/Under

The Titans went 12-4-1 O/U last season, while the Cardinals were 5-11 against the number while going Under the projected total in each of their first six games.

However, with Tennessee having added to an offense that averaged more than 30 points per game last season and with a defense that averaged 27.4 points per game allowed that isn’t expected to be much better, the Titans will be involved in a ton of high-scoring affairs.

Both teams will move the ball. The Titans will test the youth of the Cardinals linebackers and pick on CB Marco Wilson, who will start as a rookie.

This game is destined to come down to the wire with a lot of points.

Take OVER 52.5 (-108).

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com. Please gamble responsibly.

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