The Arizona Cardinals (4-9-1) face the NFC West division-leading Seattle Seahawks (11-3) for the second time this season. The game will kick off at 4:25 p.m. ET Sunday at CenturyLink Field. We analyze the Cardinals-Seahawks sports betting odds and lines, with NFL betting picks and tips for the Week 16 matchup.
Cardinals at Seahawks: Week 16 preview, betting trends and notes
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- The Cardinals are coming off a 38-24 home win over the Cleveland Browns which snapped a six-game losing streak.
- The two teams played in Arizona in Week 4. The Seahawks won 27-10.
- Cardinals QB Kyler Murray is the only player in the league with over 3,000 passing yards and 500 rushing yards. He has thrown five interceptions over his last three games to bring his season total to 10.
- Seattle is 10-1 this season in games played within one score.
- Seahawks RB Chris Carson has rushed for 1,190 yards and seven touchdowns over 14 games. He has had six games with at least 100 rushing yards.
Cardinals at Seahawks: Key injuries
Seahawks S Quandre Diggs (ankle) is not expected to play. LB Bobby Wagner (ankle), DE Jadeveon Clowney (core) and CB Shaquill Griffin (hamstring) all could miss the game.
Cardinals WR Christian Kirk (ankle) will be questionable.
Cardinals at Seahawks: Odds, betting lines and prediction
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 12:30 p.m. ET.
Prediction
Seahawks 27, Cardinals 23.
Moneyline (?)
The Seahawks (-455) won’t win much, but considering the fact they are playing at home against a team coming off a six-game losing streak with one of the worst defenses in the league, it is the only bet that makes sense. The Cardinals (+350) will give you a big win, but it isn’t likely enough to be worth a wager.
A $10 bet on the Seahawks will return a profit of $2.20 with an outright win. It’s chalky, and is best avoided.
Against the Spread (?)
The Seahawks are favored by 9.5 points (-110). The Cardinals are 8-5-1 against the spread this season and the Seahawks have been involved in 11 games decided by eight or fewer points.
The Cardinals have played competitively most of the season and the Seahawks could be without several defensive starters. That combined with their habit of close games means the smart money is on the Cardinals to keep it close. Take the CARDINALS (+9.5, -110) to stay within 9 points in a loss, or win outright.
Over/Under (?)
The total is set at 50.5 points. Both teams hit the Over in eight of their 14 games this season. The Cardinals give up a lot of points but can also score. However, with the point total so high, it will be hard to hit. It will be close, but take the UNDER (-110), as two of the Cardinals’ last three games played to the Under.
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