The Arizona Cardinals (2-3) are on the road in Week 6 for a divisional game against the Seattle Seahawks (2-3). Sunday’s kickoff at Lumen Field is 4:05 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Cardinals vs. Seahawks odds, and make our expert NFL picks and predictions.
The Cardinals lost 20-17 to the Philadelphia Eagles last week, missing a 43-yard game-tying field goal with 22 seconds left. They are 2-0 on the road, but 0-3 at home this season.
The Seahawks lost 39-32 in Week 5 to the New Orleans Saints, allowing them to rush for 235 yards. Seattle has the league’s 7th-ranked offense, led by QB Geno Smith, who is having a career resurgence in his 1st regular starting job since 2014. The Seattle defense, though, is 31st in points and last in yards allowed.
Also see: All Week 6 odds and lines
FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+
Cardinals at Seahawks odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:31 p.m. ET.
- Moneyline (ML): Cardinals -135 (bet $135 to win $100) | Seahawks +115 (bet $100 to win $115)
- Against the spread (ATS): Cardinals -2.5 (-115) | Seahawks +2.5 (-105)
- Over/Under (O/U): 50.5 (O: -110 | U: -110)
Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!
Cardinals at Seahawks key injuries
Cardinals
- RB James Conner (ribs) out
- OL Rodney Hudson (knee) questionable
- DL Rashard Lawrence (hand) questionable
- CB Byron Murphy (groin) questionable
- K Matt Prater (right hip) out
- RB Darrel Williams (knee) out
Seahawks
- WR Dee Eskridge (illness) questionable
- WR Marquise Goodwin (knee, back) questionable
- DE Shelby Harris (hip)
- OL Gabe Jackson (knee, hip) doubtful
- NT Al Woods (knee) doubtful
Play our free daily Pick’em Challenge and win! Play now!
Cardinals at Seahawks picks and predictions
Prediction
Cardinals 27, Seahawks 20
Moneyline
The Cardinals have been very good on the road the last 2 seasons, going 10-1 in the regular season.
Seattle has been fantastic offensively, but the Cardinals defense just held a higher-ranked Eagles offense to their lowest point total and yardage output of the season.
Seattle’s defense is far worse than the Eagles’. The Cardinals, who have not scored in the 1st quarter this season, should be able to score early and often on Sunday.
Take the CARDINALS (-135).
Against the spread
The Cardinals have covered the spread in both of their road wins this season. They were 8-1 ATS last season in the regular season on the road.
Only 1 of the Cardinals’ last 13 victories have been by fewer than 3 points.
All 3 of Seattle’s losses this season have been by at least 4 points.
Take the CARDINALS -2.5 (-115).
Over/Under
Only the last 2 games for the Seahawks have had more than 50 total points.
The Cardinals’ last 3 games have not had a total higher than 42 points and only 1 of their games this season has hit the Over.
Arizona held the Eagles, who had averaged 28.8 points per game entering the game last week, to 20.
Take UNDER 50.5 (-110).
More NFL Week 6 odds, picks and predictions
- Parlay: Let’s make some money
- Best picks: Underdogs | Player props | Survivor
Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!
If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.
Follow Jess Root on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.
Access more NFL coverage:
BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
[lawrence-newsletter]
[lawrence-auto-related count=3 category=1367]