Cardinals 49ers odds lines money line against the spread Over Under

First look: Arizona Cardinals at San Francisco 49ers odds and lines

Looking at Sunday’s Arizona Cardinals at San Francisco 49ers Week 5 NFL odds, lines and trends. Here’s what you need to know.

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The Arizona Cardinals (1-3) are on the road in Week 5 to take on the San Francisco 49ers (2-2) on Sunday. Kickoff from Levi’s Stadium is at 4:05 p.m. ET (FOX). Below, we look at Cardinals vs. 49ers odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Cardinals have lost 2 straight games after a 41-10 win over the LA Rams in Week 2. They lost 42-14 on Sunday at home to the Washington Commanders, allowing 449 total yards and 216 on the ground. The Cardinals were 3.5-point favorites and the Over (49) hit in the loss.

The 49ers evened their record on Sunday, beating the New England Patriots 30-13, covering the 10.5-point spread as home favorites. The Over (42.5) cashed in.

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Cardinals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 10:46 a.m. ET.

Moneyline (ML): Cardinals +300 (bet $100 to win $300) | 49ers -375 (bet $375 to win $100)
Against the spread (ATS): Cardinals +7.5 (-110) | 49ers -7.5 (-110)
Over/Under (O/U): 49.5 (O: -110 | U: -110)

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2024 betting stats

ML: Cardinals 1-3 | 49ers 2-2
ATS: Cardinals 2-2 | 49ers 2-2
O/U: Cardinals 3-1 | 49ers 3-1

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Cardinals vs. 49ers head-to-head

The Cardinals and 49ers have played each other 75 times. The Niners lead 36-29 and won the last 4 meetings and 7 of the last 10.

In 8 career starts against San Francisco, Cardinals QB Kyler Murray is 2-6, but has through 10 TD passes and only 3 INTs. He has also rushed for 2 TDs against them.

The 49ers beat Arizona 45-29 in Arizona and 35-16 in Santa Clara last season. 49ers QB Brock Purdy is 4-0 against Arizona with 8 TD passes and no INTs.

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First look: Arizona Cardinals at San Francisco 49ers odds and lines

Looking at Sunday’s Arizona Cardinals at San Francisco 49ers Week 4 NFL odds, lines and trends. Here’s what you need to know.

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The Arizona Cardinals (1-2) visit the San Francisco 49ers (3-0) Sunday in Week 4. Kickoff from Levi’s Stadium is at 4:25 p.m. ET (FOX). Below, we look at Cardinals vs. 49ers odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The Cardinals picked up their first win of the season in Week 3, defeating the Dallas Cowboys 28-16 as 11-point home underdogs. Arizona rushed for 222 yards in its 3rd straight game vs. the NFC East.

The 49ers improved to 3-0 with a 30-12 win over the New York Giants as 10.5-point favorites on Thursday Night Football. QB Brock Purdy has thrown 4 touchdown passes without an interception so far this season.

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Cardinals at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 12:53 p.m. ET.

Moneyline (ML): Cardinals +600 (bet $100 to win $600) | 49ers -900 (bet $900 to win $100)
Against the spread (ATS): Cardinals +14 (-110) | 49ers -14 (-xxx)
Over/Under (O/U): 43.5 (O: -110 | U: -110)

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2023 betting stats

ML: Cardinals 1-2 | 49ers 3-0
ATS: Cardinals 3-0 | 49ers 2-1
O/U: Cardinals 2-1 | 49ers 1-2

Cardinals vs. 49ers head-to-head

Dating back to 1961, the 49ers lead the all-time series 34-29. They won both meetings last season and have won 4 of the last 7 meetings.

Purdy is 2-0 in 2 career starts against the Cardinals and has 3 touchdown passes with no interceptions.

Cardinals QB Josh Dobbs has never played against the 49ers.

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First look: Arizona Cardinals at San Francisco 49ers odds and lines

Looking at Sunday’s Arizona Cardinals at San Francisco 49ers Week 18 NFL odds, lines and trends. Here’s what you need to know.

The Arizona Cardinals (4-12) wrap up the regular season on the road against the NFC West champion San Francisco 49ers (12-4) in Week 18. Kickoff is Sunday at 4:25 p.m. ET at Levi’s Stadium in Santa Clara (FOX). Below, we look at Cardinals vs. 49ers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Cardinals lost their 6th consecutive game Sunday, falling to the Atlanta Falcons 20-19 on a last-second 21-yard field goal. They covered the 7-point spread as underdogs with fourth-string QB David Blough starting.

The 49ers have won 9 straight games, recently needing overtime for a 37-34 victory at the Las Vegas Raiders in Week 17. However, they failed to cover as 10-point favorites, snapping a streak of 6 consecutive covers.

Also see: All Week 18 odds and lines

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Cardinals at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 12:08 a.m. ET.

Moneyline (ML): Cardinals +650 (bet $100 to win $650) | 49ers -1000 (bet $1,000 to win $100)
Against the spread (ATS): Cardinals +14 (-104) | 49ers -14 (-116)
Over/Under (O/U): 40.5 (O: -110 | U: -110)

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2022 betting stats

ML: Cardinals 4-12 | 49ers 12-4
ATS: Cardinals 8-8 | 49ers 10-6
O/U: Cardinals 8-8 | 49ers 8-8

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Cardinals vs. 49ers head-to-head

The 49ers won the first meeting in Week 11 in Mexico City 38-10 as 10-point favorites — the Cardinals were the designated home team. The 49ers hold a slight 33-29 all-time advantage, but the Cardinals have won 2 of the last 3.

This will be 49ers QB Brock Purdy’s 1st career start against the Cardinals.

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First look: Arizona Cardinals at San Francisco 49ers odds and lines

Looking at Sunday’s Arizona Cardinals at San Francisco 49ers Week 9 NFL odds, lines and trends. Here’s what you need to know.

The Arizona Cardinals (7-1) face the San Francisco 49ers (3-4) in an NFC West showdown Sunday of Week 9. Kickoff for the rivals’ second meeting of the season is set for 4:25 p.m. ET at Levi’s Stadium in Santa Clara, Calif. Below, we look at the Cardinals vs. 49ers odds and lines; check back for our NFL picks and predictions.

The Cardinals suffered their first loss of the season in Week 8, falling 24-21 to the Green Bay Packers Thursday night. QB Kyler Murray threw an end-zone interception with 12 seconds remaining in the game. Murray, who finished with two interceptions in the loss, injured his ankle and his status for Week 9 is uncertain.

The 49ers ended a four-game losing streak Sunday, defeating the Chicago Bears 33-22 at Soldier Field. QB Jimmy Garoppolo passed for 322 yards and rushed for two touchdowns, while RB Elijah Mitchell finished with 137 rushing yards and a score.

Cardinals at 49ers odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 6:27 p.m. ET.

Money line: Cardinals -145 (bet $145 to win $100) | 49ers +120 (bet $100 to win $120)
Against the spread (ATS): Cardinals -2.5, -120 (bet $120 to win $100) | 49ers +2.5, +100 (bet $100 to win $100)
Over/Under (O/U): 46.5, O: -108 (bet $108 to win $100) | U: -112 (bet $112 to win $100)

Also see: Betting 101

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2021 betting stats:

ML: Cardinals 7-1 | 49ers 3-4
ATS: Cardinals 6-2 | 49ers 2-5
O/U: Cardinals 3-5 | 49ers 4-3

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Cardinals at 49ers head-to-head

The two teams met in Arizona in Week 5 with the Cardinals picking up a 17-10 win.

They have now played each other 60 times, with the 49ers winning 32 of the matchups.

The Cardinals have won 10 of the last 13 matchups. They split the season series in 2020.

Murray is 2-3 against the 49ers in his career, while Garoppolo is 3-1 in four career starts against the Cardinals. He missed the last two games against the Cardinals due to injuries.

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