The Buffalo Bills (4-1) travel to meet the Tennessee Titans (3-2) at Nissan Stadium for Monday Night Football in Week 6. Kickoff is scheduled for 8:15 p.m. ET and the game is televised on ESPN. Below, we look at the Bills vs. Titans odds and lines, and make our best NFL picks, predictions and bets.
The Bills picked up their fourth consecutive win and cover in Kansas City Sunday night in Week 5. The Buffalo offense has been on fire, too, going for 35 or more points in four straight outings.
The Titans registered a 37-19 win on the road against the Jacksonville Jaguars in Week 5, bouncing back from a stunning overtime loss against the New York Jets in the previous week. The Under has cashed in each of Tennessee’s previous two games at home.
Bills at Titans odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 7:25 a.m. ET.
- Money line: Bills -260 (bet $260 to win $100) | Titans +205 (bet $100 to win $205)
- Against the spread (ATS): Bills -5.5 (-117) | Titans +5.5 (-103)
- Over/Under (O/U): 53.5 (O: -105 | U: -115)
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Bills at Titans key injuries
Bills
- No notables injuries to report
Titans
- RB Jeremy McNichols (ankle) questionable
- WR Chester Rogers (groin) questionable
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Bills at Titans odds, lines, predictions and picks
Prediction
Bills 30, Titans 27
Money line
The Bills (-260) are playing a second consecutive marquee, nationally televised game against a top AFC opponent for the second straight week. Buffalo proved in Kansas City that it is here to stay, but can they bring it for a second straight outing?
AVOID, as risking more than two-and-a-half times your potential return on a road team against a top-tier team is not a good betting strategy.
Against the spread
The TITANS +5.5 (-103) have a couple of depth players who will be sidelined, but the most important thing is that WRs A.J. Brown and Julio Jones are back and healthy. Tennessee has the horses on offense to hang right with Buffalo, especially on its home field in front of a raucous crowd.
Over/Under
The OVER 53.5 (-115) is the play in this Monday nighter. Buffalo’s offense has been on fire lately, and Tennessee is healthy and ready to roll. That extra day between last week’s layup at Jacksonville, and this matchup will really serve them well. Look for plenty of points.
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